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Article: Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease

TitleFamilial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease
Authors
Issue Date2000
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2000, v. 176 FEB., p. 156-159 How to Cite?
AbstractBackground: Alzheimer's disease manifests considerable heterogeneity, the cause of which is unknown. Aims: To determine the familial (genotypic) influence on phenomenology (phenotype) in Alzheimer's disease. Method: Affected sibling pairs with Alzheimer's disease were assessed for a range of cognitive and non-cognitive symptoms. Resemblance for phenotypic characteristics was estimated using intraclass correlations for continuous traits and by pair wise concordance for dichotomous traits. The relationship between age of onset and APOE genotype was examined using linear regression analysis. Results: Significant familial effects on age of onset (intraclass correlation 0.41) and mood state (intraclass correlation 0.26), and a relatively high pairwise concordance for agitation (excess concordance 0.1) were found. The APOE locus was found to account for 4% of the variance in age of onset. Conclusions: Substantial familial influence on age of onset, depression and agitation suggests that genotype does influence phenotype in Alzheimer's disease. Establishing the molecular basis for this phenotypic variation may prove relevant to other neuropsychiatric disorders. Declaration of interest: Funding received from the Medical Research Council (project grant G9530757N).
Persistent Identifierhttp://hdl.handle.net/10722/175824
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTunstall, Nen_US
dc.contributor.authorOwen, MJen_US
dc.contributor.authorWilliams, Jen_US
dc.contributor.authorRice, Fen_US
dc.contributor.authorCarty, Sen_US
dc.contributor.authorLillystone, Sen_US
dc.contributor.authorFraser, Len_US
dc.contributor.authorKehoe, Pen_US
dc.contributor.authorNeill, Den_US
dc.contributor.authorRudrasingham, Ven_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorLovestone, Sen_US
dc.date.accessioned2012-11-26T09:01:36Z-
dc.date.available2012-11-26T09:01:36Z-
dc.date.issued2000en_US
dc.identifier.citationBritish Journal Of Psychiatry, 2000, v. 176 FEB., p. 156-159en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175824-
dc.description.abstractBackground: Alzheimer's disease manifests considerable heterogeneity, the cause of which is unknown. Aims: To determine the familial (genotypic) influence on phenomenology (phenotype) in Alzheimer's disease. Method: Affected sibling pairs with Alzheimer's disease were assessed for a range of cognitive and non-cognitive symptoms. Resemblance for phenotypic characteristics was estimated using intraclass correlations for continuous traits and by pair wise concordance for dichotomous traits. The relationship between age of onset and APOE genotype was examined using linear regression analysis. Results: Significant familial effects on age of onset (intraclass correlation 0.41) and mood state (intraclass correlation 0.26), and a relatively high pairwise concordance for agitation (excess concordance 0.1) were found. The APOE locus was found to account for 4% of the variance in age of onset. Conclusions: Substantial familial influence on age of onset, depression and agitation suggests that genotype does influence phenotype in Alzheimer's disease. Establishing the molecular basis for this phenotypic variation may prove relevant to other neuropsychiatric disorders. Declaration of interest: Funding received from the Medical Research Council (project grant G9530757N).en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAffecten_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAlzheimer Disease - Geneticsen_US
dc.subject.meshCornell Medical Indexen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetics, Behavioralen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.titleFamilial influence on variation in age of onset and behavioural phenotype in Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.176.2.156en_US
dc.identifier.pmid10755053-
dc.identifier.scopuseid_2-s2.0-0034434888en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034434888&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume176en_US
dc.identifier.issueFEB.en_US
dc.identifier.spage156en_US
dc.identifier.epage159en_US
dc.identifier.isiWOS:000085292400011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTunstall, N=6602898262en_US
dc.identifier.scopusauthoridOwen, MJ=36044041500en_US
dc.identifier.scopusauthoridWilliams, J=35378880500en_US
dc.identifier.scopusauthoridRice, F=7004377110en_US
dc.identifier.scopusauthoridCarty, S=7006342439en_US
dc.identifier.scopusauthoridLillystone, S=6506453196en_US
dc.identifier.scopusauthoridFraser, L=7102793006en_US
dc.identifier.scopusauthoridKehoe, P=7006249660en_US
dc.identifier.scopusauthoridNeill, D=7004890188en_US
dc.identifier.scopusauthoridRudrasingham, V=6507296698en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridLovestone, S=7005575001en_US

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