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Article: Association analysis of polymorphisms in the μ opioid gene and heroin abuse in Chinese subjects

TitleAssociation analysis of polymorphisms in the μ opioid gene and heroin abuse in Chinese subjects
Authors
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.addiction-ssa.org/ssa_aj.htm
Citation
Addiction Biology, 2000, v. 5 n. 2, p. 181-186 How to Cite?
AbstractWe examined four polymorphisms in the μ opioid receptor gene in 282 Chinese heroin addicts from Sichuan Province, Southwest China and compared the allele and genotype frequencies to those in 258 normal controls from the same geographic region. Two of these polymorphisms (Ala6Val and Ser147Cys) were not polymorphic in the Chinese, with only Ala6 a,ld Ser147 observed. The frequencies of the two other polymorphisms were significantly different from those observed in Caucasians, African Americans and Native Americans. The Asn40Asp and IVS2 + 691G/C polymorphisms did not differ significantly for allele (p = 0.16; p = 0. 21), genotype (p = 0.32; p = 0.09) or haplotype frequencies (p = 0.24) between the Chinese heroin-addicted cases and normal controls. Similarly, we did not detect any association when the population was stratified by gender, route of administration (nasal inhalation and/or injection) and age-at-onset (above or below 25 years). This indicates that the μ opioid receptor is not likely to be a major genetic risk factor for heroin abuse in this population.
Persistent Identifierhttp://hdl.handle.net/10722/175823
ISSN
2015 Impact Factor: 4.547
2015 SCImago Journal Rankings: 2.091
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorZhu, ZHen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:35Z-
dc.date.available2012-11-26T09:01:35Z-
dc.date.issued2000en_US
dc.identifier.citationAddiction Biology, 2000, v. 5 n. 2, p. 181-186en_US
dc.identifier.issn1355-6215en_US
dc.identifier.urihttp://hdl.handle.net/10722/175823-
dc.description.abstractWe examined four polymorphisms in the μ opioid receptor gene in 282 Chinese heroin addicts from Sichuan Province, Southwest China and compared the allele and genotype frequencies to those in 258 normal controls from the same geographic region. Two of these polymorphisms (Ala6Val and Ser147Cys) were not polymorphic in the Chinese, with only Ala6 a,ld Ser147 observed. The frequencies of the two other polymorphisms were significantly different from those observed in Caucasians, African Americans and Native Americans. The Asn40Asp and IVS2 + 691G/C polymorphisms did not differ significantly for allele (p = 0.16; p = 0. 21), genotype (p = 0.32; p = 0.09) or haplotype frequencies (p = 0.24) between the Chinese heroin-addicted cases and normal controls. Similarly, we did not detect any association when the population was stratified by gender, route of administration (nasal inhalation and/or injection) and age-at-onset (above or below 25 years). This indicates that the μ opioid receptor is not likely to be a major genetic risk factor for heroin abuse in this population.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.addiction-ssa.org/ssa_aj.htmen_US
dc.relation.ispartofAddiction Biologyen_US
dc.titleAssociation analysis of polymorphisms in the μ opioid gene and heroin abuse in Chinese subjectsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/13556210050003775en_US
dc.identifier.pmid20575833-
dc.identifier.scopuseid_2-s2.0-0034105935en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034105935&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume5en_US
dc.identifier.issue2en_US
dc.identifier.spage181en_US
dc.identifier.epage186en_US
dc.identifier.isiWOS:000086841300008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridZhu, ZH=7404803102en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridHu, X=7404709241en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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