Article: 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations

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Title102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations
AuthorsHe, L4
Li, T1
Melville, C2
Liu, S4
Feng, GY5
Gu, NF5
Fox, H2
Shaw, D2
Breen, G2
Liu, X4
Sham, P1
Brown, J2
Collier, D1
St Clair, D2 3
Issue Date1999
CitationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1999, v. 88 n. 1, p. 95-98 [How to Cite?]
DOI: http://dx.doi.org/10.1002/(SICI)1096-8628(19990205)88:1<95::AID-AJMG17>3.0.CO;2-O
AbstractSeveral pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported. We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK. We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.
ISSN0148-7299
DOIhttp://dx.doi.org/10.1002/(SICI)1096-8628(19990205)88:1<95::AID-AJMG17>3.0.CO;2-O
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHe, L
dc.contributor.authorLi, T
dc.contributor.authorMelville, C
dc.contributor.authorLiu, S
dc.contributor.authorFeng, GY
dc.contributor.authorGu, NF
dc.contributor.authorFox, H
dc.contributor.authorShaw, D
dc.contributor.authorBreen, G
dc.contributor.authorLiu, X
dc.contributor.authorSham, P
dc.contributor.authorBrown, J
dc.contributor.authorCollier, D
dc.contributor.authorSt Clair, D
dc.date.accessioned2012-11-26T09:01:29Z
dc.date.available2012-11-26T09:01:29Z
dc.date.issued1999
dc.description.abstractSeveral pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported. We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK. We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1999, v. 88 n. 1, p. 95-98 [How to Cite?]
DOI: http://dx.doi.org/10.1002/(SICI)1096-8628(19990205)88:1<95::AID-AJMG17>3.0.CO;2-O
dc.identifier.doihttp://dx.doi.org/10.1002/(SICI)1096-8628(19990205)88:1<95::AID-AJMG17>3.0.CO;2-O
dc.identifier.epage98
dc.identifier.issn0148-7299
dc.identifier.issue1
dc.identifier.pmid10050975
dc.identifier.scopuseid_2-s2.0-0033525172
dc.identifier.spage95
dc.identifier.urihttp://hdl.handle.net/10722/175810
dc.identifier.volume88
dc.languageeng
dc.publisher.placeUnited States
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
dc.relation.referencesReferences in Scopus
dc.subject.meshCarrier Proteins - Genetics
dc.subject.meshCase-Control Studies
dc.subject.meshChina
dc.subject.meshGenotype
dc.subject.meshGreat Britain
dc.subject.meshHumans
dc.subject.meshMembrane Glycoproteins - Genetics
dc.subject.meshMembrane Transport Proteins
dc.subject.meshNerve Tissue Proteins
dc.subject.meshPolymorphism, Genetic
dc.subject.meshReceptors, Serotonin - Genetics
dc.subject.meshSchizophrenia - Genetics
dc.subject.meshSerotonin Plasma Membrane Transport Proteins
dc.title102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations
dc.typeArticle
Author Affiliations
  1. King's College London
  2. University of Aberdeen
  3. University of Aberdeen School of Medicine
  4. Chinese Academy of Sciences
  5. Shanghai Mental Health Center