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Article: 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations

Title102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations
Authors
Issue Date1999
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1999, v. 88 n. 1, p. 95-98 How to Cite?
Abstract
Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported. We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK. We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.
Persistent Identifierhttp://hdl.handle.net/10722/175810
ISSN
ISI Accession Number ID
References

 

Author Affiliations
  1. King's College London
  2. University of Aberdeen
  3. University of Aberdeen School of Medicine
  4. Chinese Academy of Sciences
  5. Shanghai Mental Health Center
DC FieldValueLanguage
dc.contributor.authorHe, Len_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorMelville, Cen_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorFeng, GYen_US
dc.contributor.authorGu, NFen_US
dc.contributor.authorFox, Hen_US
dc.contributor.authorShaw, Den_US
dc.contributor.authorBreen, Gen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorBrown, Jen_US
dc.contributor.authorCollier, Den_US
dc.contributor.authorSt Clair, Den_US
dc.date.accessioned2012-11-26T09:01:29Z-
dc.date.available2012-11-26T09:01:29Z-
dc.date.issued1999en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1999, v. 88 n. 1, p. 95-98en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175810-
dc.description.abstractSeveral pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported. We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK. We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChinaen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Glycoproteins - Geneticsen_US
dc.subject.meshMembrane Transport Proteinsen_US
dc.subject.meshNerve Tissue Proteinsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshSerotonin Plasma Membrane Transport Proteinsen_US
dc.title102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populationsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1096-8628(19990205)88:1<95::AID-AJMG17>3.0.CO;2-Oen_US
dc.identifier.pmid10050975en_US
dc.identifier.scopuseid_2-s2.0-0033525172en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033525172&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume88en_US
dc.identifier.issue1en_US
dc.identifier.spage95en_US
dc.identifier.epage98en_US
dc.identifier.isiWOS:000078397400017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHe, L=36080215400en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridMelville, C=36822252500en_US
dc.identifier.scopusauthoridLiu, S=8905643900en_US
dc.identifier.scopusauthoridFeng, GY=36698795100en_US
dc.identifier.scopusauthoridGu, NF=7102669732en_US
dc.identifier.scopusauthoridFox, H=7202912250en_US
dc.identifier.scopusauthoridShaw, D=7403341741en_US
dc.identifier.scopusauthoridBreen, G=15742166000en_US
dc.identifier.scopusauthoridLiu, X=7409294386en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridBrown, J=7409449227en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US
dc.identifier.scopusauthoridSt Clair, D=35354078200en_US

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