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Article: No evidence of linkage disequilibrium between a CAG repeat in the SCA1 gene and schizophrenia in Caucasian and Chinese schizophrenic subjects

TitleNo evidence of linkage disequilibrium between a CAG repeat in the SCA1 gene and schizophrenia in Caucasian and Chinese schizophrenic subjects
Authors
Issue Date1999
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.com
Citation
Psychiatric Genetics, 1999, v. 9 n. 3, p. 123-127 How to Cite?
AbstractSeveral recent studies have reported evidence for a schizophrenia locus on chromosome 6p, with a variety of linked markers spanning a ~ 40 cM region between D6S470 and D6S291. However because of the wide region implicated and the difficulty of inferring phenotype from genotype in complex disorders, it is difficult to define its location precisely using linkage data. An alternative approach is to search for linkage disequilibrium. On chromosome 6p, allelic association with a (CAG) 29 allele of a triplet repeat marker in the SCA1 gene has been reported, and we have attempted to replicate this finding using a Caucasian case-control sample of 211 affected subjects and 204 controls, and a Han Chinese sample of 100 affected family trios. In the case-control sample, the frequency of the (CAG) 29 allele was similar in cases and controls (35), and no other alleles provided evidence for allelic association. Likewise, there was no evidence for preferential transmission of the (CAG) 29 allele to affected offspring in the Chinese sample, although a different allele, (CAG) 26, was more often transmitted to the affected offspring. However this data did not reach statistical significance (P = 0.1). We conclude that our data does not support the notion that there is a locus for schizophrenia close to the SCA1 gene. However, since linkage disequilibrium will vary between distinct populations, we cannot exclude this possibility. (C) 1999 Lippincott Williams and Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/175809
ISSN
2015 Impact Factor: 1.736
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorBreen, Gen_US
dc.contributor.authorBrown, Jen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorShaw, DJen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorSt Clair, Den_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:28Z-
dc.date.available2012-11-26T09:01:28Z-
dc.date.issued1999en_US
dc.identifier.citationPsychiatric Genetics, 1999, v. 9 n. 3, p. 123-127en_US
dc.identifier.issn0955-8829en_US
dc.identifier.urihttp://hdl.handle.net/10722/175809-
dc.description.abstractSeveral recent studies have reported evidence for a schizophrenia locus on chromosome 6p, with a variety of linked markers spanning a ~ 40 cM region between D6S470 and D6S291. However because of the wide region implicated and the difficulty of inferring phenotype from genotype in complex disorders, it is difficult to define its location precisely using linkage data. An alternative approach is to search for linkage disequilibrium. On chromosome 6p, allelic association with a (CAG) 29 allele of a triplet repeat marker in the SCA1 gene has been reported, and we have attempted to replicate this finding using a Caucasian case-control sample of 211 affected subjects and 204 controls, and a Han Chinese sample of 100 affected family trios. In the case-control sample, the frequency of the (CAG) 29 allele was similar in cases and controls (35), and no other alleles provided evidence for allelic association. Likewise, there was no evidence for preferential transmission of the (CAG) 29 allele to affected offspring in the Chinese sample, although a different allele, (CAG) 26, was more often transmitted to the affected offspring. However this data did not reach statistical significance (P = 0.1). We conclude that our data does not support the notion that there is a locus for schizophrenia close to the SCA1 gene. However, since linkage disequilibrium will vary between distinct populations, we cannot exclude this possibility. (C) 1999 Lippincott Williams and Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.comen_US
dc.relation.ispartofPsychiatric Geneticsen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve Tissue Proteins - Geneticsen_US
dc.subject.meshNuclear Familyen_US
dc.subject.meshNuclear Proteins - Geneticsen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshScotlanden_US
dc.subject.meshTrinucleotide Repeatsen_US
dc.titleNo evidence of linkage disequilibrium between a CAG repeat in the SCA1 gene and schizophrenia in Caucasian and Chinese schizophrenic subjectsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00041444-199909000-00002-
dc.identifier.pmid10551541-
dc.identifier.scopuseid_2-s2.0-0033388524en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033388524&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue3en_US
dc.identifier.spage123en_US
dc.identifier.epage127en_US
dc.identifier.isiWOS:000083506000002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridBreen, G=15742166000en_US
dc.identifier.scopusauthoridBrown, J=7409449227en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridShaw, DJ=7403341741en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridSt Clair, D=35354078200en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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