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Article: Heritability estimates for psychotic disorders: The Maudsley Twin psychosis series

TitleHeritability estimates for psychotic disorders: The Maudsley Twin psychosis series
Authors
Issue Date1999
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.com
Citation
Archives Of General Psychiatry, 1999, v. 56 n. 2, p. 162-168 How to Cite?
AbstractBackground: Previous twin studies have supported a genetic contribution to the major categories of psychotic disorders, but few of these have employed operational diagnostic criteria, and no such study has been based on a sample that included the full range of functional psychotic disorders. Methods: A total of 224 twin probands (106 monozygotic, 118 dizygotic) with a same-sex co-twin and a lifetime history of psychosis was ascertained from the service-based Maudsley Twin Register in London, England. Research Diagnostic Criteria psychotic diagnoses were made on a lifetime-ever basis. Main- lifetime diagnoses of DSM-III-R and International Statistical Classification of Diseases, 10th Revision schizophrenia were also made. Probandwise concordance rates and correlations in liability were calculated, and biometrical model fitting applied. Results: A substantial genetic contribution to variance in liability was confirmed for the major diagnostic categories except Research Diagnostic Criteria depressive psychosis and unspecified functional psychosis, where familial transmission was confirmed but the relative contribution of genetic and common environmental factors was unclear. Heritability estimates for Research Diagnostic Criteria schizophrenia, schizoaffective disorder, mania, DSM-III-R schizophrenia, and International Statistical Classification of Diseases, loth Revision schizophrenia were all between 82% and 85%. None of the estimates differed significantly from any other. Conclusions: Heritability estimates for schizophrenia, schizoaffective disorder, and mania were substantial and similar. Population morbid risk estimates were inferred rather than directly measured, but the results were very similar to those from studies where morbid risks were directly estimated.
Persistent Identifierhttp://hdl.handle.net/10722/175804
ISSN
2014 Impact Factor: 14.48
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCardno, AGen_US
dc.contributor.authorMarshall, EJen_US
dc.contributor.authorCoid, Ben_US
dc.contributor.authorMacdonald, AMen_US
dc.contributor.authorRibchester, TRen_US
dc.contributor.authorDavies, NJen_US
dc.contributor.authorVenturi, Pen_US
dc.contributor.authorJones, LAen_US
dc.contributor.authorLewis, SWen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorGottesman, IIen_US
dc.contributor.authorFarmer, AEen_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorReveley, AMen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:01:26Z-
dc.date.available2012-11-26T09:01:26Z-
dc.date.issued1999en_US
dc.identifier.citationArchives Of General Psychiatry, 1999, v. 56 n. 2, p. 162-168en_US
dc.identifier.issn0003-990Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175804-
dc.description.abstractBackground: Previous twin studies have supported a genetic contribution to the major categories of psychotic disorders, but few of these have employed operational diagnostic criteria, and no such study has been based on a sample that included the full range of functional psychotic disorders. Methods: A total of 224 twin probands (106 monozygotic, 118 dizygotic) with a same-sex co-twin and a lifetime history of psychosis was ascertained from the service-based Maudsley Twin Register in London, England. Research Diagnostic Criteria psychotic diagnoses were made on a lifetime-ever basis. Main- lifetime diagnoses of DSM-III-R and International Statistical Classification of Diseases, 10th Revision schizophrenia were also made. Probandwise concordance rates and correlations in liability were calculated, and biometrical model fitting applied. Results: A substantial genetic contribution to variance in liability was confirmed for the major diagnostic categories except Research Diagnostic Criteria depressive psychosis and unspecified functional psychosis, where familial transmission was confirmed but the relative contribution of genetic and common environmental factors was unclear. Heritability estimates for Research Diagnostic Criteria schizophrenia, schizoaffective disorder, mania, DSM-III-R schizophrenia, and International Statistical Classification of Diseases, loth Revision schizophrenia were all between 82% and 85%. None of the estimates differed significantly from any other. Conclusions: Heritability estimates for schizophrenia, schizoaffective disorder, and mania were substantial and similar. Population morbid risk estimates were inferred rather than directly measured, but the results were very similar to those from studies where morbid risks were directly estimated.en_US
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.comen_US
dc.relation.ispartofArchives of General Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshBipolar Disorder - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshDiseases In Twins - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshLondon - Epidemiologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPsychiatric Status Rating Scales - Statistics & Numerical Dataen_US
dc.subject.meshPsychotic Disorders - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshRegistriesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshTwins, Dizygotic - Geneticsen_US
dc.subject.meshTwins, Monozygotic - Geneticsen_US
dc.titleHeritability estimates for psychotic disorders: The Maudsley Twin psychosis seriesen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1001/archpsyc.56.2.162en_US
dc.identifier.pmid10025441-
dc.identifier.scopuseid_2-s2.0-0033040141en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033040141&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue2en_US
dc.identifier.spage162en_US
dc.identifier.epage168en_US
dc.identifier.isiWOS:000078553600007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCardno, AG=7004499892en_US
dc.identifier.scopusauthoridMarshall, EJ=10339840400en_US
dc.identifier.scopusauthoridCoid, B=6507977783en_US
dc.identifier.scopusauthoridMacdonald, AM=35557766100en_US
dc.identifier.scopusauthoridRibchester, TR=6506172219en_US
dc.identifier.scopusauthoridDavies, NJ=7202610654en_US
dc.identifier.scopusauthoridVenturi, P=6603816251en_US
dc.identifier.scopusauthoridJones, LA=34769954100en_US
dc.identifier.scopusauthoridLewis, SW=7404041267en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridGottesman, II=7005588519en_US
dc.identifier.scopusauthoridFarmer, AE=7102158824en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridReveley, AM=6701641246en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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