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Article: A transmission/disequilibrium study of the DRB1*04 gene locus on chromosome 6p21.3 with schizophrenia

TitleA transmission/disequilibrium study of the DRB1*04 gene locus on chromosome 6p21.3 with schizophrenia
Authors
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 1998, v. 32 n. 2, p. 75-80 How to Cite?
AbstractPatients with schizophrenia rarely develop rheumatoid arthritis, an autoimmune disease that exhibits genetic association with the HLA DRB1*04 gene. We previously investigated the hypothesis that schizophrenia is negatively associated with DRB1*04, and found that only half the expected number of schizophrenic patients had this gene when compared with controls. We now report the results of DRB1*04 genotyping in pedigrees multiply affected with schizophrenia. Polymerase chain reaction amplification and sequence-specific oligonucleotide probes were used to determine the DRB1 genotypes of the 187 members of 23 pedigrees multiply affected with RDC schizophrenia. DQA1, DQB1 and DPB1 genotypes were similarly determined. We analysed data using the extended transmission/disequilibrium test and found a trend for the preferential non-transmission of DRB1*04 alleles from heterozygous parents to their schizophrenic offspring (16 of 23 alleles not transmitted, χ2= 3.5, p = 0.06). We found no evidence for a gene of major effect using GENEHUNTER for parametric and non-parametric linkage analysis. The results from this small sample need to be interpreted with caution, but they are in keeping with previous reports and suggest that HLA DRB1*04 alleles may be associated with a reduced risk of schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/175794
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWright, Pen_US
dc.contributor.authorDawson, Een_US
dc.contributor.authorDonaldson, PTen_US
dc.contributor.authorUnderhill, JAen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorGill, Men_US
dc.contributor.authorNanko, Sen_US
dc.contributor.authorOwen, MJen_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:01:21Z-
dc.date.available2012-11-26T09:01:21Z-
dc.date.issued1998en_US
dc.identifier.citationSchizophrenia Research, 1998, v. 32 n. 2, p. 75-80en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175794-
dc.description.abstractPatients with schizophrenia rarely develop rheumatoid arthritis, an autoimmune disease that exhibits genetic association with the HLA DRB1*04 gene. We previously investigated the hypothesis that schizophrenia is negatively associated with DRB1*04, and found that only half the expected number of schizophrenic patients had this gene when compared with controls. We now report the results of DRB1*04 genotyping in pedigrees multiply affected with schizophrenia. Polymerase chain reaction amplification and sequence-specific oligonucleotide probes were used to determine the DRB1 genotypes of the 187 members of 23 pedigrees multiply affected with RDC schizophrenia. DQA1, DQB1 and DPB1 genotypes were similarly determined. We analysed data using the extended transmission/disequilibrium test and found a trend for the preferential non-transmission of DRB1*04 alleles from heterozygous parents to their schizophrenic offspring (16 of 23 alleles not transmitted, χ2= 3.5, p = 0.06). We found no evidence for a gene of major effect using GENEHUNTER for parametric and non-parametric linkage analysis. The results from this small sample need to be interpreted with caution, but they are in keeping with previous reports and suggest that HLA DRB1*04 alleles may be associated with a reduced risk of schizophrenia.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAllelesen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 6 - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHla-Dr Antigens - Geneticsen_US
dc.subject.meshHla-Drb1 Chainsen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibrium - Geneticsen_US
dc.subject.meshPedigreeen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.titleA transmission/disequilibrium study of the DRB1*04 gene locus on chromosome 6p21.3 with schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(98)00050-4en_US
dc.identifier.pmid9713901-
dc.identifier.scopuseid_2-s2.0-0032572609en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032572609&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue2en_US
dc.identifier.spage75en_US
dc.identifier.epage80en_US
dc.identifier.isiWOS:000075204800001-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridWright, P=7404316244en_US
dc.identifier.scopusauthoridDawson, E=7102147964en_US
dc.identifier.scopusauthoridDonaldson, PT=7102342412en_US
dc.identifier.scopusauthoridUnderhill, JA=7006500448en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridGill, M=35228962600en_US
dc.identifier.scopusauthoridNanko, S=16181663700en_US
dc.identifier.scopusauthoridOwen, MJ=36044041500en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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