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Article: Family history as a predictor of poor long-term outcome in depression

TitleFamily history as a predictor of poor long-term outcome in depression
Authors
Issue Date1998
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1998, v. 173 DEC., p. 527-530 How to Cite?
AbstractBackground We investigated whether family history had prognostic significance in depression in a study which addressed some of the methodological short-comings of previous studies. Method We collected family history data on a consecutive series of 89 patients admitted with RDC major depression, blind to the outcome of the proband. This comprised 116, 283 and 120 first-degree relatives examined with the SADS-L, FH-RDC and case note data, respectively. The outcome of 74 of these probands (83%), previously categorised into four operationally defined groups, was then examined. Results A positive family history of severe psychiatric illness (i.e. a relative with a history of either a psychosis, hospitalised depression or suicide) was associated with poor outcome in the proband. This association persisted after controlling for variable family size, age structure and gender. As family history was correlated with neither Kendell's neurotic/psychotic index nor the proband's neuroticism score, an individual with high scores an all three would have a greatly increased chance of having a poor outcome. Conclusions A family history of severe psychiatric illness in a first-degree relative may be useful as one of the vulnerability factors for predicting poor long-term outcome in depression.
Persistent Identifierhttp://hdl.handle.net/10722/175781
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuggan, Cen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorMinne, Cen_US
dc.contributor.authorLee, Aen_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-11-26T09:01:15Z-
dc.date.available2012-11-26T09:01:15Z-
dc.date.issued1998en_US
dc.identifier.citationBritish Journal Of Psychiatry, 1998, v. 173 DEC., p. 527-530en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175781-
dc.description.abstractBackground We investigated whether family history had prognostic significance in depression in a study which addressed some of the methodological short-comings of previous studies. Method We collected family history data on a consecutive series of 89 patients admitted with RDC major depression, blind to the outcome of the proband. This comprised 116, 283 and 120 first-degree relatives examined with the SADS-L, FH-RDC and case note data, respectively. The outcome of 74 of these probands (83%), previously categorised into four operationally defined groups, was then examined. Results A positive family history of severe psychiatric illness (i.e. a relative with a history of either a psychosis, hospitalised depression or suicide) was associated with poor outcome in the proband. This association persisted after controlling for variable family size, age structure and gender. As family history was correlated with neither Kendell's neurotic/psychotic index nor the proband's neuroticism score, an individual with high scores an all three would have a greatly increased chance of having a poor outcome. Conclusions A family history of severe psychiatric illness in a first-degree relative may be useful as one of the vulnerability factors for predicting poor long-term outcome in depression.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshDepressive Disorder - Geneticsen_US
dc.subject.meshFamily Characteristicsen_US
dc.subject.meshFamily Healthen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitalization - Statistics & Numerical Dataen_US
dc.subject.meshHumansen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPedigreeen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Factorsen_US
dc.titleFamily history as a predictor of poor long-term outcome in depressionen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.173.6.527-
dc.identifier.pmid9926084-
dc.identifier.scopuseid_2-s2.0-0031764632en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031764632&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume173en_US
dc.identifier.issueDEC.en_US
dc.identifier.spage527en_US
dc.identifier.epage530en_US
dc.identifier.isiWOS:000077605400015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridDuggan, C=7101812173en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridMinne, C=55393727700en_US
dc.identifier.scopusauthoridLee, A=19135120800en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

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