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Article: Association analysis of the dopamine D4 gene exon 111 VNTR and heroin abuse in Chinese subjects

TitleAssociation analysis of the dopamine D4 gene exon 111 VNTR and heroin abuse in Chinese subjects
Authors
KeywordsAddiction
Allelic Association
Behaviour Genetics
Catecholamines
Opioids
Substance Abuse
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
Citation
Molecular Psychiatry, 1997, v. 2 n. 5, p. 413-416 How to Cite?
AbstractAlthough social and cultural influences are clearly important, family, twin and adoption studies indicate that genes contribute significantly to substance abuse. 1-3 Substance abuse is associated with novelty seeking, a heritable human personality trait which may be influenced by alleles of the dopamine D4 (DRD4) gene exon III VNTR. 4,5 Consequently Kotler et al 6 analysed the DRD4 VNTR in opiate-dependent subjects from Israel, and found a significant excess of the 7-repeat allele. We have attempted to replicate this finding using a Han Chinese case-control sample of 121 heroin-dependent subjects and 154 normal controls. We found two 7-repeat alleles which occurred exclusively in the patient group, and overall there was an excess of longer alleles, which did not reach significance (χ = 7.04; P=0.07). When the D4 VNTR was divided into 'long' (5-7 repeats) and 'short' (2-4 repeats), a significant excess of long alleles was observed in the patient group (P= 0.023, one-tailed), with an odds ratio of 2.30 (95% CI 1.07-4.93). We conclude that our findings support the hypothesis that alleles of the DRD4 exon III VNTR are susceptibility factors for heroin abuse. © 1997 Stockton Press All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175777
ISSN
2015 Impact Factor: 13.314
2015 SCImago Journal Rankings: 6.790
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorXu, Ken_US
dc.contributor.authorDeng, Hen_US
dc.contributor.authorCai, Gen_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorWang, Ren_US
dc.contributor.authorXiang, Xen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:13Z-
dc.date.available2012-11-26T09:01:13Z-
dc.date.issued1997en_US
dc.identifier.citationMolecular Psychiatry, 1997, v. 2 n. 5, p. 413-416en_US
dc.identifier.issn1359-4184en_US
dc.identifier.urihttp://hdl.handle.net/10722/175777-
dc.description.abstractAlthough social and cultural influences are clearly important, family, twin and adoption studies indicate that genes contribute significantly to substance abuse. 1-3 Substance abuse is associated with novelty seeking, a heritable human personality trait which may be influenced by alleles of the dopamine D4 (DRD4) gene exon III VNTR. 4,5 Consequently Kotler et al 6 analysed the DRD4 VNTR in opiate-dependent subjects from Israel, and found a significant excess of the 7-repeat allele. We have attempted to replicate this finding using a Han Chinese case-control sample of 121 heroin-dependent subjects and 154 normal controls. We found two 7-repeat alleles which occurred exclusively in the patient group, and overall there was an excess of longer alleles, which did not reach significance (χ = 7.04; P=0.07). When the D4 VNTR was divided into 'long' (5-7 repeats) and 'short' (2-4 repeats), a significant excess of long alleles was observed in the patient group (P= 0.023, one-tailed), with an odds ratio of 2.30 (95% CI 1.07-4.93). We conclude that our findings support the hypothesis that alleles of the DRD4 exon III VNTR are susceptibility factors for heroin abuse. © 1997 Stockton Press All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mpen_US
dc.relation.ispartofMolecular Psychiatryen_US
dc.subjectAddictionen_US
dc.subjectAllelic Associationen_US
dc.subjectBehaviour Geneticsen_US
dc.subjectCatecholaminesen_US
dc.subjectOpioidsen_US
dc.subjectSubstance Abuseen_US
dc.titleAssociation analysis of the dopamine D4 gene exon 111 VNTR and heroin abuse in Chinese subjectsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0031228025en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031228025&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_US
dc.identifier.issue5en_US
dc.identifier.spage413en_US
dc.identifier.epage416en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridXu, K=38663744200en_US
dc.identifier.scopusauthoridDeng, H=34568563000en_US
dc.identifier.scopusauthoridCai, G=15134875600en_US
dc.identifier.scopusauthoridLiu, J=36072193800en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridWang, R=25631362900en_US
dc.identifier.scopusauthoridXiang, X=8712146800en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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