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Article: Psychopathological syndromes and familial morbid risk of psychosis

TitlePsychopathological syndromes and familial morbid risk of psychosis
Authors
Issue Date1997
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1997, v. 170 MAR., p. 241-246 How to Cite?
AbstractBackground - Familial liability in the functional psychoses had traditionally been examined by comparing mutually exclusive diagnostic categories. This study examines overlapping psychopathological dimensions in relation to familial morbid risk of psychosis. Method - We tested for associations between seven factor-analysis derived psychopathological dimensions and familial morbid risk of psychosis, in a sample of 150 patients with recent-onset functional psychosis and 548 of their first-degree relatives. Results - A syndrome characterised by affective blunting and insidious and early onset of illness, non-specifically predicted psychosis in the first-degree relatives, whereas a manic syndrome specifically predicted affective psychosis in the relatives. No other main effects were observed, but there were interactions with proband diagnosis: a syndrome characterised by bizarre behaviour, inappropriate affect, catatonia and poor rapport predicted psychosis in relatives of schizophrenic probands, and a syndrome of depressive symptoms predicted psychosis in relatives of schizoaffective probands. Positive symptoms were not associated with illness in the relatives. Conclusions - Genetic effects in the functional psychoses may comprise non-specific components that canalise a general, early-onset, affective blunting phenotype and several other, more specific, influences on phenotypic variation.
Persistent Identifierhttp://hdl.handle.net/10722/175771
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVan Os, Jen_US
dc.contributor.authorMarcelis, Men_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorJones, Pen_US
dc.contributor.authorGilvarry, Ken_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-11-26T09:01:11Z-
dc.date.available2012-11-26T09:01:11Z-
dc.date.issued1997en_US
dc.identifier.citationBritish Journal Of Psychiatry, 1997, v. 170 MAR., p. 241-246en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175771-
dc.description.abstractBackground - Familial liability in the functional psychoses had traditionally been examined by comparing mutually exclusive diagnostic categories. This study examines overlapping psychopathological dimensions in relation to familial morbid risk of psychosis. Method - We tested for associations between seven factor-analysis derived psychopathological dimensions and familial morbid risk of psychosis, in a sample of 150 patients with recent-onset functional psychosis and 548 of their first-degree relatives. Results - A syndrome characterised by affective blunting and insidious and early onset of illness, non-specifically predicted psychosis in the first-degree relatives, whereas a manic syndrome specifically predicted affective psychosis in the relatives. No other main effects were observed, but there were interactions with proband diagnosis: a syndrome characterised by bizarre behaviour, inappropriate affect, catatonia and poor rapport predicted psychosis in relatives of schizophrenic probands, and a syndrome of depressive symptoms predicted psychosis in relatives of schizoaffective probands. Positive symptoms were not associated with illness in the relatives. Conclusions - Genetic effects in the functional psychoses may comprise non-specific components that canalise a general, early-onset, affective blunting phenotype and several other, more specific, influences on phenotypic variation.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAffective Disorders, Psychotic - Geneticsen_US
dc.subject.meshFamily Healthen_US
dc.subject.meshHumansen_US
dc.subject.meshPsychotic Disorders - Geneticsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshSyndromeen_US
dc.titlePsychopathological syndromes and familial morbid risk of psychosisen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.170.3.241-
dc.identifier.pmid9229030-
dc.identifier.scopuseid_2-s2.0-0030931225en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030931225&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume170en_US
dc.identifier.issueMAR.en_US
dc.identifier.spage241en_US
dc.identifier.epage246en_US
dc.identifier.isiWOS:A1997WP36700006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridVan Os, J=7102358027en_US
dc.identifier.scopusauthoridMarcelis, M=6603325363en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridJones, P=36078972900en_US
dc.identifier.scopusauthoridGilvarry, K=6508391739en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

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