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Article: Morbid risk of schizophrenia in first-degree relatives of White and African-Caribbean patients with psychosis

TitleMorbid risk of schizophrenia in first-degree relatives of White and African-Caribbean patients with psychosis
Authors
Issue Date1996
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1996, v. 169 n. 6, p. 776-780 How to Cite?
AbstractBackground. The high rate of schizophrenia among the second-generation African-Caribbean population in Britain has prompted much concern and speculation. Sugarman and Craufurd have reported that the morbid risk in the siblings of second-generation African-Caribbean schizophrenic patients was unusually high compared with that of the siblings of White patients. Method. We sought to replicate these findings by comparing the morbid risk for schizophrenia in the first-degree relatives of 111 White and 73 African-Caribbean psychotic probands. The latter comprised 35 first-generation (born in the Caribbean) and 38 second-generation (born in Britain) probands. Results. The morbid risk for schizophrenia was similar for the parents and siblings of White and first-generation African-Caribbean patients, and for the parents of the second-generation African-Caribbean probands. However, the siblings of second-generation African-Caribbean psychotic probands had a morbid risk for schizophrenia that was seven times that of their White counterparts (P=0.007); similarly, the siblings of second-generation African-Caribbean schizophrenic probands had a morbid risk for schizophrenia that was four times that of their White counterparts (P=0.05). Conclusions. These findings replicate those of the earlier report of Sugarman and Craufurd, and suggest either that the second-generation African-Caribbean population in Britain is particularly vulnerable to some environmental risk factors for schizophrenia, or that some environmental factors act selectively on this population in Britain.
Persistent Identifierhttp://hdl.handle.net/10722/175748
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHutchinson, Gen_US
dc.contributor.authorTakei, Nen_US
dc.contributor.authorFahy, TAen_US
dc.contributor.authorBhugra, Den_US
dc.contributor.authorGilvarry, Cen_US
dc.contributor.authorMoran, Pen_US
dc.contributor.authorMallett, Ren_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorLeff, Jen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:00:57Z-
dc.date.available2012-11-26T09:00:57Z-
dc.date.issued1996en_US
dc.identifier.citationBritish Journal Of Psychiatry, 1996, v. 169 n. 6, p. 776-780en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175748-
dc.description.abstractBackground. The high rate of schizophrenia among the second-generation African-Caribbean population in Britain has prompted much concern and speculation. Sugarman and Craufurd have reported that the morbid risk in the siblings of second-generation African-Caribbean schizophrenic patients was unusually high compared with that of the siblings of White patients. Method. We sought to replicate these findings by comparing the morbid risk for schizophrenia in the first-degree relatives of 111 White and 73 African-Caribbean psychotic probands. The latter comprised 35 first-generation (born in the Caribbean) and 38 second-generation (born in Britain) probands. Results. The morbid risk for schizophrenia was similar for the parents and siblings of White and first-generation African-Caribbean patients, and for the parents of the second-generation African-Caribbean probands. However, the siblings of second-generation African-Caribbean psychotic probands had a morbid risk for schizophrenia that was seven times that of their White counterparts (P=0.007); similarly, the siblings of second-generation African-Caribbean schizophrenic probands had a morbid risk for schizophrenia that was four times that of their White counterparts (P=0.05). Conclusions. These findings replicate those of the earlier report of Sugarman and Craufurd, and suggest either that the second-generation African-Caribbean population in Britain is particularly vulnerable to some environmental risk factors for schizophrenia, or that some environmental factors act selectively on this population in Britain.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAfrica - Ethnologyen_US
dc.subject.meshAfrican Americans - Psychologyen_US
dc.subject.meshAfrican Continental Ancestry Group - Geneticsen_US
dc.subject.meshChild Of Impaired Parents - Psychologyen_US
dc.subject.meshCross-Cultural Comparisonen_US
dc.subject.meshEuropean Continental Ancestry Group - Genetics - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGreat Britain - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPsychotic Disorders - Diagnosis - Ethnology - Geneticsen_US
dc.subject.meshRisken_US
dc.subject.meshSchizophrenia - Diagnosis - Ethnology - Geneticsen_US
dc.subject.meshSocial Environmenten_US
dc.subject.meshWest Indies - Ethnologyen_US
dc.titleMorbid risk of schizophrenia in first-degree relatives of White and African-Caribbean patients with psychosisen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.169.6.776-
dc.identifier.pmid8968638-
dc.identifier.scopuseid_2-s2.0-0029913969en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029913969&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume169en_US
dc.identifier.issue6en_US
dc.identifier.spage776en_US
dc.identifier.epage780en_US
dc.identifier.isiWOS:A1996VX57000017-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHutchinson, G=35113301500en_US
dc.identifier.scopusauthoridTakei, N=7102701392en_US
dc.identifier.scopusauthoridFahy, TA=8077630100en_US
dc.identifier.scopusauthoridBhugra, D=7006858005en_US
dc.identifier.scopusauthoridGilvarry, C=6701857173en_US
dc.identifier.scopusauthoridMoran, P=34571973600en_US
dc.identifier.scopusauthoridMallett, R=7004817370en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridLeff, J=7102081288en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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