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Article: Genetic epidemiology

TitleGenetic epidemiology
Authors
Issue Date1996
PublisherOxford University Press. The Journal's web site is located at http://bmb.oxfordjournals.org/
Citation
British Medical Bulletin, 1996, v. 52 n. 3, p. 408-433 How to Cite?
AbstractStudies of families, twins, and adoptees have helped to quantify the genetic contributions to and overlaps between depression, anxiety, phobias and alcoholism, and to refine the boundaries of the schizophrenia spectrum. Analyses of covariance structures in twin data have confirmed genetic susceptibility and recent life stresses as the major determinants of depression. Genetic modelling of family data on schizophrenia and bipolar disorder indicates three or more common genes each having a small multiplicative effect on risk, although rare major genes may be present in some families. Linkage studies have localised genes for familial Alzheimer's disease on chromosomes 14 and 21; disease mutations on these chromosomes have since been isolated. Association studies have identified susceptibility (or protective) genes for Alzheimer's disease and alcoholism. Several tentative linkage and association findings in schizophrenia and bipolar disorder require further study.
Persistent Identifierhttp://hdl.handle.net/10722/175741
ISSN
2015 Impact Factor: 2.921
2015 SCImago Journal Rankings: 1.391
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:00:53Z-
dc.date.available2012-11-26T09:00:53Z-
dc.date.issued1996en_US
dc.identifier.citationBritish Medical Bulletin, 1996, v. 52 n. 3, p. 408-433en_US
dc.identifier.issn0007-1420en_US
dc.identifier.urihttp://hdl.handle.net/10722/175741-
dc.description.abstractStudies of families, twins, and adoptees have helped to quantify the genetic contributions to and overlaps between depression, anxiety, phobias and alcoholism, and to refine the boundaries of the schizophrenia spectrum. Analyses of covariance structures in twin data have confirmed genetic susceptibility and recent life stresses as the major determinants of depression. Genetic modelling of family data on schizophrenia and bipolar disorder indicates three or more common genes each having a small multiplicative effect on risk, although rare major genes may be present in some families. Linkage studies have localised genes for familial Alzheimer's disease on chromosomes 14 and 21; disease mutations on these chromosomes have since been isolated. Association studies have identified susceptibility (or protective) genes for Alzheimer's disease and alcoholism. Several tentative linkage and association findings in schizophrenia and bipolar disorder require further study.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://bmb.oxfordjournals.org/en_US
dc.relation.ispartofBritish Medical Bulletinen_US
dc.subject.meshAlcoholism - Psychologyen_US
dc.subject.meshDisease Susceptibilityen_US
dc.subject.meshEpidemiologic Methodsen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshHumansen_US
dc.subject.meshMental Disorders - Epidemiology - Geneticsen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshSubstance-Related Disorders - Geneticsen_US
dc.titleGenetic epidemiologyen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8949247-
dc.identifier.scopuseid_2-s2.0-0029780453en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029780453&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume52en_US
dc.identifier.issue3en_US
dc.identifier.spage408en_US
dc.identifier.epage433en_US
dc.identifier.isiWOS:A1996VJ61000002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSham, P=34573429300en_US

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