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Article: Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?

TitleDoes prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?
Authors
Issue Date1995
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 1995, v. 16 n. 3, p. 233-241 How to Cite?
AbstractEpidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.
Persistent Identifierhttp://hdl.handle.net/10722/175733
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCotter, Den_US
dc.contributor.authorTakei, Nen_US
dc.contributor.authorFarrell, Men_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorQuinn, Pen_US
dc.contributor.authorLarkin, Cen_US
dc.contributor.authorOxford, Jen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorO'callaghan, Een_US
dc.date.accessioned2012-11-26T09:00:50Z-
dc.date.available2012-11-26T09:00:50Z-
dc.date.issued1995en_US
dc.identifier.citationSchizophrenia Research, 1995, v. 16 n. 3, p. 233-241en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175733-
dc.description.abstractEpidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHippocampus - Pathologyen_US
dc.subject.meshInfluenza A Virusen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshOrthomyxoviridae Infections - Pathologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Exposure Delayed Effectsen_US
dc.subject.meshPyramidal Cells - Pathologyen_US
dc.titleDoes prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?en_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0920-9964(94)E0082-Ien_US
dc.identifier.pmid7488569-
dc.identifier.scopuseid_2-s2.0-0029117776en_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.spage233en_US
dc.identifier.epage241en_US
dc.identifier.isiWOS:A1995RT06400007-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridCotter, D=7101938570en_US
dc.identifier.scopusauthoridTakei, N=35874982900en_US
dc.identifier.scopusauthoridFarrell, M=7202679298en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridQuinn, P=55160024500en_US
dc.identifier.scopusauthoridLarkin, C=7006768069en_US
dc.identifier.scopusauthoridOxford, J=7102877671en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridO'Callaghan, E=7005694363en_US

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