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Article: Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1

TitleLinkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1
Authors
Issue Date1995
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 2, p. 94-102 How to Cite?
AbstractWe have recently described a family in which there is cosegregation of major affective disorder with Darier's disease and have mapped this autosomal dominant skin disorder to 12q23-q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independent researchers should examine markers from this region in further samples of bipolar pedigrees.
Persistent Identifierhttp://hdl.handle.net/10722/175723
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDawson, Een_US
dc.contributor.authorParfitt, Een_US
dc.contributor.authorRoberts, Qen_US
dc.contributor.authorDaniels, Jen_US
dc.contributor.authorLim, Len_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorNothen, Men_US
dc.contributor.authorPropping, Pen_US
dc.contributor.authorLanczik, Men_US
dc.contributor.authorMaier, Wen_US
dc.contributor.authorReuner, Uen_US
dc.contributor.authorWeissenbach, Jen_US
dc.contributor.authorGill, Men_US
dc.contributor.authorPowell, Jen_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorCraddock, Nen_US
dc.date.accessioned2012-11-26T09:00:46Z-
dc.date.available2012-11-26T09:00:46Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 2, p. 94-102en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175723-
dc.description.abstractWe have recently described a family in which there is cosegregation of major affective disorder with Darier's disease and have mapped this autosomal dominant skin disorder to 12q23-q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independent researchers should examine markers from this region in further samples of bipolar pedigrees.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshBipolar Disorder - Enzymology - Geneticsen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 12 - Geneticsen_US
dc.subject.meshDarier Disease - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Dominanten_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLod Scoreen_US
dc.subject.meshMaleen_US
dc.subject.meshPedigreeen_US
dc.subject.meshPhospholipases A - Geneticsen_US
dc.subject.meshPhospholipases A2en_US
dc.titleLinkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1en_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.1320600203-
dc.identifier.pmid7485258-
dc.identifier.scopuseid_2-s2.0-0028965001en_US
dc.identifier.volume60en_US
dc.identifier.issue2en_US
dc.identifier.spage94en_US
dc.identifier.epage102en_US
dc.identifier.isiWOS:A1995QT74500002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDawson, E=7102147964en_US
dc.identifier.scopusauthoridParfitt, E=6701860602en_US
dc.identifier.scopusauthoridRoberts, Q=7801600567en_US
dc.identifier.scopusauthoridDaniels, J=35407969900en_US
dc.identifier.scopusauthoridLim, L=36484937000en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridNothen, M=35355123900en_US
dc.identifier.scopusauthoridPropping, P=35355673000en_US
dc.identifier.scopusauthoridLanczik, M=7004279110en_US
dc.identifier.scopusauthoridMaier, W=36046783700en_US
dc.identifier.scopusauthoridReuner, U=6602325890en_US
dc.identifier.scopusauthoridWeissenbach, J=7103101117en_US
dc.identifier.scopusauthoridGill, M=35228962600en_US
dc.identifier.scopusauthoridPowell, J=7403541196en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridCraddock, N=35352014300en_US

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