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Article: A typological model of schizophrenia based on age at onset, sex and familial morbidity

TitleA typological model of schizophrenia based on age at onset, sex and familial morbidity
Authors
Issue Date1994
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACP
Citation
Acta Psychiatrica Scandinavica, 1994, v. 89 n. 2, p. 135-141 How to Cite?
AbstractWe investigated the age at onset distributions of schizophrenia in men and women and the relationship of age at onset and sex to the familial rates of schizophrenia and manic-depression in data from a Swedish family study of 270 schizophrenic probands. On the logarithmic scale, the age at onset distribution of schizophrenia in both male and female relatives was bimodal, suggesting that broadly defined schizophrenia may be a mixture of 2 (probably related) disorders. The risk of schizophrenia in relatives decreased as a function of the age at onset of the proband, irrespective of the sex of the proband or relative. In contrast, the risk of manic-depression was significantly higher in relatives of female probands with an age at onset in the twenties than in relatives of female probands with earlier or later onset, or in relatives of male probands. This suggests a third disorder related to affective psychosis, with an intermediate age at onset and female preponderance.
Persistent Identifierhttp://hdl.handle.net/10722/175693
ISSN
2015 Impact Factor: 6.128
2015 SCImago Journal Rankings: 2.518
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSham, PCen_US
dc.contributor.authorMaclean, CJen_US
dc.contributor.authorKendler, KSen_US
dc.date.accessioned2012-11-26T09:00:32Z-
dc.date.available2012-11-26T09:00:32Z-
dc.date.issued1994en_US
dc.identifier.citationActa Psychiatrica Scandinavica, 1994, v. 89 n. 2, p. 135-141en_US
dc.identifier.issn0001-690Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175693-
dc.description.abstractWe investigated the age at onset distributions of schizophrenia in men and women and the relationship of age at onset and sex to the familial rates of schizophrenia and manic-depression in data from a Swedish family study of 270 schizophrenic probands. On the logarithmic scale, the age at onset distribution of schizophrenia in both male and female relatives was bimodal, suggesting that broadly defined schizophrenia may be a mixture of 2 (probably related) disorders. The risk of schizophrenia in relatives decreased as a function of the age at onset of the proband, irrespective of the sex of the proband or relative. In contrast, the risk of manic-depression was significantly higher in relatives of female probands with an age at onset in the twenties than in relatives of female probands with earlier or later onset, or in relatives of male probands. This suggests a third disorder related to affective psychosis, with an intermediate age at onset and female preponderance.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACPen_US
dc.relation.ispartofActa Psychiatrica Scandinavicaen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBipolar Disorder - Diagnosis - Epidemiology - Genetics - Psychologyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSweden - Epidemiologyen_US
dc.titleA typological model of schizophrenia based on age at onset, sex and familial morbidityen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0447.1994.tb01501.x-
dc.identifier.pmid8178665-
dc.identifier.scopuseid_2-s2.0-0028047740en_US
dc.identifier.volume89en_US
dc.identifier.issue2en_US
dc.identifier.spage135en_US
dc.identifier.epage141en_US
dc.identifier.isiWOS:A1994MV75400011-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridMacLean, CJ=7102972772en_US
dc.identifier.scopusauthoridKendler, KS=35396760800en_US

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