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Article: Risk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis?

TitleRisk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis?
Authors
Issue Date1993
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1993, v. 163 NOV., p. 627-633 How to Cite?
AbstractRecent reports that some influenza epidemics may be followed by a transient increase in the births of schizophrenic patients have led to the hypothesis that maternal viral infections contribute to the aetiology of schizophrenia. It is well known that respiratory viral infections are frequently brought into the home by young children. We tested the predictions that the risk of schizophrenia is decreased in first-born children, and increased in individuals who had siblings of a young age while in utero, using data from a Swedish family study. Our results are consistent with these predictions. In particular, having siblings three to four years older was associated with a significantly increased risk of schizophrenia, even after allowing for birth order, sibship size, and other potential confounders. If replicated, these results provide indirect support for the maternal viral infection hypothesis, although there an alternative explanations.
Persistent Identifierhttp://hdl.handle.net/10722/175687
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSham, PCen_US
dc.contributor.authorMaclean, CJen_US
dc.contributor.authorKendler, KSen_US
dc.date.accessioned2012-11-26T09:00:30Z-
dc.date.available2012-11-26T09:00:30Z-
dc.date.issued1993en_US
dc.identifier.citationBritish Journal Of Psychiatry, 1993, v. 163 NOV., p. 627-633en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175687-
dc.description.abstractRecent reports that some influenza epidemics may be followed by a transient increase in the births of schizophrenic patients have led to the hypothesis that maternal viral infections contribute to the aetiology of schizophrenia. It is well known that respiratory viral infections are frequently brought into the home by young children. We tested the predictions that the risk of schizophrenia is decreased in first-born children, and increased in individuals who had siblings of a young age while in utero, using data from a Swedish family study. Our results are consistent with these predictions. In particular, having siblings three to four years older was associated with a significantly increased risk of schizophrenia, even after allowing for birth order, sibship size, and other potential confounders. If replicated, these results provide indirect support for the maternal viral infection hypothesis, although there an alternative explanations.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshBirth Orderen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza, Human - Complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMaternal Welfareen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Exposure Delayed Effectsen_US
dc.subject.meshSchizophrenia - Etiologyen_US
dc.titleRisk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis?en_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.163.5.627-
dc.identifier.pmid8298831-
dc.identifier.scopuseid_2-s2.0-0027496755en_US
dc.identifier.volume163en_US
dc.identifier.issueNOV.en_US
dc.identifier.spage627en_US
dc.identifier.epage633en_US
dc.identifier.isiWOS:A1993MG52100009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridMaclean, CJ=7102972772en_US
dc.identifier.scopusauthoridKendler, KS=35396760800en_US

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