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Article: Frequent occurrence of new hepatobiliary abnormalities after bone marrow transplantation: Results of a prospective study using scintigraphy and sonography

TitleFrequent occurrence of new hepatobiliary abnormalities after bone marrow transplantation: Results of a prospective study using scintigraphy and sonography
Authors
Issue Date1993
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 1993, v. 88 n. 7, p. 1044-1049 How to Cite?
AbstractWith hepatobiliary scintigraphy and sonography, we prospectively studied the occurrence of new hepatobiliary abnormalities in 18 patients before, and from 1 to 103 days after, bone marrow transplantation (BMT). Prior to BMT, all patients had normal hepatic uptake and visualization of the gallbladder by 60 min on scintigraphy, and no sludge, stones, or other abnormalities on sonography. After BMT, 16 patients (89%) developed new scintigraphic and/or sonographic hepatobiliary abnormalities. Fifteen patients had impaired liver uptake of mebrofenin, while 11 developed gallbladder sludge and/or stones, and 10 had gallbladder nonvisualization at 60 min. Nevertheless, no patient developed clinical or laboratory evidence of acute cholecystitis. New hepatobiliary abnormalities are more common during the first months post-BMT than clinically suspected, probably reflecting the combined effects of hepatotoxic chemoradiation therapy, graft-versus-host disease, and prolonged administration of parenteral alimentation. Evidence of acute cholecystitis is generally not found.
Persistent Identifierhttp://hdl.handle.net/10722/175681
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJacobson, AFen_US
dc.contributor.authorTeefey, SAen_US
dc.contributor.authorLee, SPen_US
dc.contributor.authorHollister, MSen_US
dc.contributor.authorHigano, CAen_US
dc.contributor.authorBianco, JAen_US
dc.date.accessioned2012-11-26T09:00:28Z-
dc.date.available2012-11-26T09:00:28Z-
dc.date.issued1993en_US
dc.identifier.citationAmerican Journal Of Gastroenterology, 1993, v. 88 n. 7, p. 1044-1049en_US
dc.identifier.issn0002-9270en_US
dc.identifier.urihttp://hdl.handle.net/10722/175681-
dc.description.abstractWith hepatobiliary scintigraphy and sonography, we prospectively studied the occurrence of new hepatobiliary abnormalities in 18 patients before, and from 1 to 103 days after, bone marrow transplantation (BMT). Prior to BMT, all patients had normal hepatic uptake and visualization of the gallbladder by 60 min on scintigraphy, and no sludge, stones, or other abnormalities on sonography. After BMT, 16 patients (89%) developed new scintigraphic and/or sonographic hepatobiliary abnormalities. Fifteen patients had impaired liver uptake of mebrofenin, while 11 developed gallbladder sludge and/or stones, and 10 had gallbladder nonvisualization at 60 min. Nevertheless, no patient developed clinical or laboratory evidence of acute cholecystitis. New hepatobiliary abnormalities are more common during the first months post-BMT than clinically suspected, probably reflecting the combined effects of hepatotoxic chemoradiation therapy, graft-versus-host disease, and prolonged administration of parenteral alimentation. Evidence of acute cholecystitis is generally not found.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_US
dc.relation.ispartofAmerican Journal of Gastroenterologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Transplantation - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder - Radionuclide Imaging - Ultrasonographyen_US
dc.subject.meshGallbladder Diseases - Etiology - Radionuclide Imaging - Ultrasonographyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver - Radionuclide Imaging - Ultrasonographyen_US
dc.subject.meshLiver Diseases - Etiology - Radionuclide Imaging - Ultrasonographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.titleFrequent occurrence of new hepatobiliary abnormalities after bone marrow transplantation: Results of a prospective study using scintigraphy and sonographyen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8317403-
dc.identifier.scopuseid_2-s2.0-0027176866en_US
dc.identifier.volume88en_US
dc.identifier.issue7en_US
dc.identifier.spage1044en_US
dc.identifier.epage1049en_US
dc.identifier.isiWOS:A1993LL28600011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJacobson, AF=7403204421en_US
dc.identifier.scopusauthoridTeefey, SA=7003608392en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridHollister, MS=6602982159en_US
dc.identifier.scopusauthoridHigano, CA=7004197065en_US
dc.identifier.scopusauthoridBianco, JA=35397676700en_US

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