File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Nature and composition of biliary sludge

TitleNature and composition of biliary sludge
Authors
Issue Date1986
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1986, v. 90 n. 3, p. 677-686 How to Cite?
AbstractTo study the microscopic and biochemical composition of biliary sludge, we subjected hepatic and gallbladder bile samples to microscopic examination, and analysis of lipids and mucus glycoprotein. These were compared with samples of hepatic and gallbladder bile obtained from normal persons and patients with gallstones. Biliary sludge was found to be sediment composed of cholesterol monohydrate crystals and bilirubin granules embedded in a matrix of mucus gel. There was a striking increase in the amount of mucus glycoprotein in the gallbladder bile of the sludge group compared with the gallstone and control group. The gallbladder biliary mucus content was also higher in the gallstone group compared with normal controls. These differences in mucus concentrations were not observed in hepatic bile samples from the three groups, suggesting that they had occurred within the gallbladder. In addition, gallbladder histology and epithelial mucin histochemical staining reaction were studied. Mucus hypersecretion and early glandular metaplasia in the epithelium were observed in the gallbladders harboring sludge, whereas those having stones had further changes in the mesenchymal tissues, with thickening and fibrosis. These results indicate that in patients with sludge the gall bladder is abnormal, showing mucus hypersecretion and glandular metaplasia. This leads to an increase in the mucus content of gallbladder bile, which in turn may result in nucleation of cholesterol crystals and may be regarded as the embryonic stage of gallstone disease.
Persistent Identifierhttp://hdl.handle.net/10722/175642
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorNicholls, JFen_US
dc.date.accessioned2012-11-26T09:00:14Z-
dc.date.available2012-11-26T09:00:14Z-
dc.date.issued1986en_US
dc.identifier.citationGastroenterology, 1986, v. 90 n. 3, p. 677-686en_US
dc.identifier.issn0016-5085en_US
dc.identifier.urihttp://hdl.handle.net/10722/175642-
dc.description.abstractTo study the microscopic and biochemical composition of biliary sludge, we subjected hepatic and gallbladder bile samples to microscopic examination, and analysis of lipids and mucus glycoprotein. These were compared with samples of hepatic and gallbladder bile obtained from normal persons and patients with gallstones. Biliary sludge was found to be sediment composed of cholesterol monohydrate crystals and bilirubin granules embedded in a matrix of mucus gel. There was a striking increase in the amount of mucus glycoprotein in the gallbladder bile of the sludge group compared with the gallstone and control group. The gallbladder biliary mucus content was also higher in the gallstone group compared with normal controls. These differences in mucus concentrations were not observed in hepatic bile samples from the three groups, suggesting that they had occurred within the gallbladder. In addition, gallbladder histology and epithelial mucin histochemical staining reaction were studied. Mucus hypersecretion and early glandular metaplasia in the epithelium were observed in the gallbladders harboring sludge, whereas those having stones had further changes in the mesenchymal tissues, with thickening and fibrosis. These results indicate that in patients with sludge the gall bladder is abnormal, showing mucus hypersecretion and glandular metaplasia. This leads to an increase in the mucus content of gallbladder bile, which in turn may result in nucleation of cholesterol crystals and may be regarded as the embryonic stage of gallstone disease.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_US
dc.relation.ispartofGastroenterologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBile - Chemistryen_US
dc.subject.meshBilirubin - Analysisen_US
dc.subject.meshCholelithiasis - Metabolism - Pathologyen_US
dc.subject.meshCholesterol - Analysisen_US
dc.subject.meshCrystallizationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder - Pathology - Secretionen_US
dc.subject.meshGlycoproteins - Analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshLipids - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMucus - Chemistry - Secretionen_US
dc.titleNature and composition of biliary sludgeen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3943697-
dc.identifier.scopuseid_2-s2.0-0022639045en_US
dc.identifier.volume90en_US
dc.identifier.issue3en_US
dc.identifier.spage677en_US
dc.identifier.epage686en_US
dc.identifier.isiWOS:A1986A019800022-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridNicholls, JF=7201464908en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats