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Article: Effects of histamine and histamine antagonists on hepatic bile flow in the conscious sheep

TitleEffects of histamine and histamine antagonists on hepatic bile flow in the conscious sheep
Authors
Issue Date1984
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1984, v. 11 n. 1, p. 61-69 How to Cite?
Abstract1. The effects of histamine and histamine antagonists on bile flow have been studied using the cholecystectomized conscious sheep. Histamine stimulated bile flow in a dose-dependent manner (D50 = 15.7 μg/h per kg). Free water and HCO3 - output were increased after intravenous histamine infusion. With histamine at 120 mg/h per kg, there was a 41.0 (s.d. = 4.6)% and 38.7 (s.d. = 4.2)% (n = 6) increase in bile volume and HCO3 - output respectively. Bile salt concentration was decreased after intravenous histamine, but net bile salt secretory rate remained unchanged. There was no change observed in the molar ratios of bile salts:phospholipids:cholesterol. Total lipids were decreased from 2.2 (s.d. = 0.3) to 1.60 (s.d. = 0.4) g/dl (n = 6). The corrected lithogenic index did not change significantly. 14C-Erythritol clearance also increased during histamine infusion in a dose-dependent manner but did not correspond to increments in bile flow. 2. The histamine H1-receptor antagonist, diphenhydramine 0.05-1.0 mg/h per kg did not alter histamine stimulated bile flow. The H2-receptor antagonists, cimetidine (0.5-4 mg/h per kg) and ranitidine (0.05-0.5 mg/h per kg) progressively reversed the histamine-induced choleresis. Maximum inhibitory effect was attained at 2.0 and 0.25 mg/h per kg for cimetidine and ranitidine, respectively. At these levels, variation of intravenous infusion of histamine did not result in competitive displacement of the inhibitory response by either cimetidine or ranitidine. Moreover, concomitant infusion of diphenhydramine at 1.0 mg/h per kg potentiated the inhibitory effect of cimetidine or ranitidine on histamine-induced choleresis. 3. Histamine increases the bile salt independent component of hepatic bile flow. This increase can be blocked by cimetidine or raniditine by a non-competitive inhibitory mechanism.
Persistent Identifierhttp://hdl.handle.net/10722/175632
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:00:12Z-
dc.date.available2012-11-26T09:00:12Z-
dc.date.issued1984en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1984, v. 11 n. 1, p. 61-69en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/175632-
dc.description.abstract1. The effects of histamine and histamine antagonists on bile flow have been studied using the cholecystectomized conscious sheep. Histamine stimulated bile flow in a dose-dependent manner (D50 = 15.7 μg/h per kg). Free water and HCO3 - output were increased after intravenous histamine infusion. With histamine at 120 mg/h per kg, there was a 41.0 (s.d. = 4.6)% and 38.7 (s.d. = 4.2)% (n = 6) increase in bile volume and HCO3 - output respectively. Bile salt concentration was decreased after intravenous histamine, but net bile salt secretory rate remained unchanged. There was no change observed in the molar ratios of bile salts:phospholipids:cholesterol. Total lipids were decreased from 2.2 (s.d. = 0.3) to 1.60 (s.d. = 0.4) g/dl (n = 6). The corrected lithogenic index did not change significantly. 14C-Erythritol clearance also increased during histamine infusion in a dose-dependent manner but did not correspond to increments in bile flow. 2. The histamine H1-receptor antagonist, diphenhydramine 0.05-1.0 mg/h per kg did not alter histamine stimulated bile flow. The H2-receptor antagonists, cimetidine (0.5-4 mg/h per kg) and ranitidine (0.05-0.5 mg/h per kg) progressively reversed the histamine-induced choleresis. Maximum inhibitory effect was attained at 2.0 and 0.25 mg/h per kg for cimetidine and ranitidine, respectively. At these levels, variation of intravenous infusion of histamine did not result in competitive displacement of the inhibitory response by either cimetidine or ranitidine. Moreover, concomitant infusion of diphenhydramine at 1.0 mg/h per kg potentiated the inhibitory effect of cimetidine or ranitidine on histamine-induced choleresis. 3. Histamine increases the bile salt independent component of hepatic bile flow. This increase can be blocked by cimetidine or raniditine by a non-competitive inhibitory mechanism.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBile - Drug Effects - Metabolismen_US
dc.subject.meshCholesterol - Metabolismen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshErythritol - Pharmacologyen_US
dc.subject.meshHistamine - Pharmacologyen_US
dc.subject.meshHistamine Antagonists - Pharmacologyen_US
dc.subject.meshHistamine H1 Antagonists - Pharmacologyen_US
dc.subject.meshHistamine H2 Antagonists - Pharmacologyen_US
dc.subject.meshLiver - Drug Effectsen_US
dc.subject.meshPhospholipids - Metabolismen_US
dc.subject.meshSheepen_US
dc.subject.meshStimulation, Chemicalen_US
dc.titleEffects of histamine and histamine antagonists on hepatic bile flow in the conscious sheepen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1984.tb00240.x-
dc.identifier.pmid6143632-
dc.identifier.scopuseid_2-s2.0-0021330489en_US
dc.identifier.volume11en_US
dc.identifier.issue1en_US
dc.identifier.spage61en_US
dc.identifier.epage69en_US
dc.identifier.isiWOS:A1984SA93400008-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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