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Article: The evolution of morphologic changes in the gallbladder before stone formation in mice fed a cholesterol-cholic acid diet

TitleThe evolution of morphologic changes in the gallbladder before stone formation in mice fed a cholesterol-cholic acid diet
Authors
Issue Date1982
PublisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org
Citation
American Journal Of Pathology, 1982, v. 108 n. 1, p. 1-8 How to Cite?
AbstractMice were fed a lithogenic diet containing 1% cholesterol and 0.5% cholic acid, and the sequence of morphologic changes in the gallbladder was followed. Histologic changes were studied with light microscopy and cell proliferation with autoradiography. Mucus glycoprotein production was studied with a spectrum of glycoprotein histochemical stains and electron-microscopic morphometry of membrane-bound mucus secretory granules. There was a rapid and early increase in cell proliferation of the epithelial cells and an increase in mucus production, which took place long before any observable cholesterol crystal precipitation. The gall-bladder epithelial cells showed early focal pseudostratification and large numbers of degenerative cells. These changes culminated in glandular metaplasia and the formation of Rokitansky-Aschoff sinuses later in the gallstone induction phase. These observations clearly indicated that gallbladder epithelial injury had taken place before gallstone formation. The authors hypothesize that the consequences of these cellular changes play a contributory role in causing gallstone formation.
Persistent Identifierhttp://hdl.handle.net/10722/175623
ISSN
2015 Impact Factor: 4.206
2015 SCImago Journal Rankings: 2.653
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorScott, AJen_US
dc.date.accessioned2012-11-26T09:00:10Z-
dc.date.available2012-11-26T09:00:10Z-
dc.date.issued1982en_US
dc.identifier.citationAmerican Journal Of Pathology, 1982, v. 108 n. 1, p. 1-8en_US
dc.identifier.issn0002-9440en_US
dc.identifier.urihttp://hdl.handle.net/10722/175623-
dc.description.abstractMice were fed a lithogenic diet containing 1% cholesterol and 0.5% cholic acid, and the sequence of morphologic changes in the gallbladder was followed. Histologic changes were studied with light microscopy and cell proliferation with autoradiography. Mucus glycoprotein production was studied with a spectrum of glycoprotein histochemical stains and electron-microscopic morphometry of membrane-bound mucus secretory granules. There was a rapid and early increase in cell proliferation of the epithelial cells and an increase in mucus production, which took place long before any observable cholesterol crystal precipitation. The gall-bladder epithelial cells showed early focal pseudostratification and large numbers of degenerative cells. These changes culminated in glandular metaplasia and the formation of Rokitansky-Aschoff sinuses later in the gallstone induction phase. These observations clearly indicated that gallbladder epithelial injury had taken place before gallstone formation. The authors hypothesize that the consequences of these cellular changes play a contributory role in causing gallstone formation.en_US
dc.languageengen_US
dc.publisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.orgen_US
dc.relation.ispartofAmerican Journal of Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCholelithiasis - Etiology - Pathologyen_US
dc.subject.meshCholesterol, Dietary - Pharmacologyen_US
dc.subject.meshCholic Acids - Pharmacologyen_US
dc.subject.meshDieten_US
dc.subject.meshEpithelium - Metabolism - Pathologyen_US
dc.subject.meshGallbladder - Pathology - Ultrastructureen_US
dc.subject.meshGlycoproteins - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshTime Factorsen_US
dc.titleThe evolution of morphologic changes in the gallbladder before stone formation in mice fed a cholesterol-cholic acid dieten_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7091297-
dc.identifier.scopuseid_2-s2.0-0019965395en_US
dc.identifier.volume108en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage8en_US
dc.identifier.isiWOS:A1982NW78500001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridScott, AJ=7403271310en_US

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