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Article: Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis

TitleHypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis
Authors
Issue Date1981
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 1981, v. 134 n. 3, p. 199-207 How to Cite?
AbstractIn three models of cholelithiasis (dihydrocholesterol-fed rabbits, cholesterol-cholic acid-fed mice, and Lincomycin-treated guinea pig), the quantity and chemical composition of gallbladder epithelial mucin have been studied using (1) a spectrum of histochemical glycoprotein stains, and (2) biochemical extraction, purification and analysis of the carbohydrate components of epithelial mucin. Despite the diverse mechanism of stone induction and difference in stone composition, a common pattern of response by the epithelial mucin was observed in all three models. There was a quantitative increase in epithelial mucus production at a time before stones were formed and this increase persisted till stones were formed. There was no difference, qualitatively, between mucus produced by normal and stone-forming gallbladders.
Persistent Identifierhttp://hdl.handle.net/10722/175619
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:00:09Z-
dc.date.available2012-11-26T09:00:09Z-
dc.date.issued1981en_US
dc.identifier.citationJournal Of Pathology, 1981, v. 134 n. 3, p. 199-207en_US
dc.identifier.issn0022-3417en_US
dc.identifier.urihttp://hdl.handle.net/10722/175619-
dc.description.abstractIn three models of cholelithiasis (dihydrocholesterol-fed rabbits, cholesterol-cholic acid-fed mice, and Lincomycin-treated guinea pig), the quantity and chemical composition of gallbladder epithelial mucin have been studied using (1) a spectrum of histochemical glycoprotein stains, and (2) biochemical extraction, purification and analysis of the carbohydrate components of epithelial mucin. Despite the diverse mechanism of stone induction and difference in stone composition, a common pattern of response by the epithelial mucin was observed in all three models. There was a quantitative increase in epithelial mucus production at a time before stones were formed and this increase persisted till stones were formed. There was no difference, qualitatively, between mucus produced by normal and stone-forming gallbladders.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_US
dc.relation.ispartofJournal of Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholelithiasis - Chemically Induced - Metabolism - Physiopathologyen_US
dc.subject.meshCholestanolen_US
dc.subject.meshCholesterolen_US
dc.subject.meshCholic Acidsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEpithelium - Analysis - Secretionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder - Analysis - Secretionen_US
dc.subject.meshGlycoproteins - Analysis - Secretionen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshLincomycinen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMucus - Analysis - Secretionen_US
dc.subject.meshRabbitsen_US
dc.titleHypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasisen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/path.1711340304-
dc.identifier.pmid6790685-
dc.identifier.scopuseid_2-s2.0-0019495222en_US
dc.identifier.volume134en_US
dc.identifier.issue3en_US
dc.identifier.spage199en_US
dc.identifier.epage207en_US
dc.identifier.isiWOS:A1981MD14400003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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