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Article: Aspirin prevention of cholesterol gallstone formation in prairie dogs

TitleAspirin prevention of cholesterol gallstone formation in prairie dogs
Authors
Issue Date1981
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 1981, v. 211 n. 4489, p. 1429-1431 How to Cite?
AbstractWhen prairie dogs (Cynomys ludovicianus) are fed a diet containing cholesterol, a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile. Gelation of mucin precedes the precipitation of cholesterol liquid and solid crystals and the development of gallstones. Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile. This suggests that gallbladder mucin is a nucleation matrix for cholesterol gallstones.
Persistent Identifierhttp://hdl.handle.net/10722/175618
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorCarey, MCen_US
dc.contributor.authorLamont, JTen_US
dc.date.accessioned2012-11-26T09:00:09Z-
dc.date.available2012-11-26T09:00:09Z-
dc.date.issued1981en_US
dc.identifier.citationScience, 1981, v. 211 n. 4489, p. 1429-1431en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/175618-
dc.description.abstractWhen prairie dogs (Cynomys ludovicianus) are fed a diet containing cholesterol, a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile. Gelation of mucin precedes the precipitation of cholesterol liquid and solid crystals and the development of gallstones. Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile. This suggests that gallbladder mucin is a nucleation matrix for cholesterol gallstones.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspirin - Pharmacology - Therapeutic Useen_US
dc.subject.meshBile - Analysisen_US
dc.subject.meshCholelithiasis - Metabolism - Prevention & Controlen_US
dc.subject.meshCholesterol, Dietary - Metabolismen_US
dc.subject.meshCrystallizationen_US
dc.subject.meshCulture Techniquesen_US
dc.subject.meshGallbladder - Secretionen_US
dc.subject.meshLipids - Analysisen_US
dc.subject.meshMucins - Secretionen_US
dc.subject.meshSciuridaeen_US
dc.subject.meshSecretory Rate - Drug Effectsen_US
dc.titleAspirin prevention of cholesterol gallstone formation in prairie dogsen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.7466399-
dc.identifier.pmid7466399-
dc.identifier.scopuseid_2-s2.0-0019433910en_US
dc.identifier.volume211en_US
dc.identifier.issue4489en_US
dc.identifier.spage1429en_US
dc.identifier.epage1431en_US
dc.identifier.isiWOS:A1981LG07300030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridCarey, MC=7202744540en_US
dc.identifier.scopusauthoridLaMont, JT=7103091181en_US

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