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Article: Effects of cimetidine on the healing of benign gastric ulcers

TitleEffects of cimetidine on the healing of benign gastric ulcers
Authors
Issue Date1980
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJ
Citation
Australian And New Zealand Journal Of Medicine, 1980, v. 10 n. 4, p. 430-432 How to Cite?
AbstractA prospective double-blind trial was undertaken to determine whether treatment with cimetidine influenced the healing of gastric ulcers in New Zealand patients. Ulcer size and healing was assessed by endoscopic examination. Of the 30 patients who completed the trial, 15 were given cimetidine and 15 placebo. At six weeks, 60% of the patients on cimetidine had healed their ulcers, whereas only 20% of those on the placebo had healed ulcers (P<0.05). Fewer patients taking cimetidine required antacids for symptom control than those on placebo treatment (P<0.05). The study confirmed that cimetidine treatment accelerates the healing of gastric ulcers. Histamine H 2 receptor antagonists have become an accepted treatment for both gastric and duodenal ulceration. In order to confirm that cimetidine is effective in the treatment of gastric ulcer in New Zealand patients, a double-blind study was carried out on outpatients with uncomplicated gastric ulcers.
Persistent Identifierhttp://hdl.handle.net/10722/175614
ISSN
2002 Impact Factor: 0.524
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorClarke, ACen_US
dc.contributor.authorLee, SPen_US
dc.contributor.authorTasmanJones, Cen_US
dc.date.accessioned2012-11-26T09:00:08Z-
dc.date.available2012-11-26T09:00:08Z-
dc.date.issued1980en_US
dc.identifier.citationAustralian And New Zealand Journal Of Medicine, 1980, v. 10 n. 4, p. 430-432en_US
dc.identifier.issn0004-8291en_US
dc.identifier.urihttp://hdl.handle.net/10722/175614-
dc.description.abstractA prospective double-blind trial was undertaken to determine whether treatment with cimetidine influenced the healing of gastric ulcers in New Zealand patients. Ulcer size and healing was assessed by endoscopic examination. Of the 30 patients who completed the trial, 15 were given cimetidine and 15 placebo. At six weeks, 60% of the patients on cimetidine had healed their ulcers, whereas only 20% of those on the placebo had healed ulcers (P<0.05). Fewer patients taking cimetidine required antacids for symptom control than those on placebo treatment (P<0.05). The study confirmed that cimetidine treatment accelerates the healing of gastric ulcers. Histamine H 2 receptor antagonists have become an accepted treatment for both gastric and duodenal ulceration. In order to confirm that cimetidine is effective in the treatment of gastric ulcer in New Zealand patients, a double-blind study was carried out on outpatients with uncomplicated gastric ulcers.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJen_US
dc.relation.ispartofAustralian and New Zealand Journal of Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntacids - Therapeutic Useen_US
dc.subject.meshCimetidine - Adverse Effects - Pharmacology - Therapeutic Useen_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshEndoscopyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastroscopyen_US
dc.subject.meshGuanidines - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshStomach Ulcer - Drug Therapyen_US
dc.subject.meshWound Healing - Drug Effectsen_US
dc.titleEffects of cimetidine on the healing of benign gastric ulcersen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1445-5994.1980.tb04095.x-
dc.identifier.pmid7000061-
dc.identifier.scopuseid_2-s2.0-0018953554en_US
dc.identifier.volume10en_US
dc.identifier.issue4en_US
dc.identifier.spage430en_US
dc.identifier.epage432en_US
dc.identifier.isiWOS:A1980KE26900008-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridClarke, AC=7403682654en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridTasmanJones, C=7003303326en_US

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