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Article: Enhanced fluid transport across gallbladder mucosa in experimental cholelithiasis.

TitleEnhanced fluid transport across gallbladder mucosa in experimental cholelithiasis.
Authors
Issue Date1978
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1978, v. 234 n. 6, p. E575-578 How to Cite?
AbstractFluid transport of the gallbladder has been studied in two models of experimental cholelithiasis: dihydrocholesterol-induced gallstones in the rabbit and lincomycin-induced gallstones in the guinea pig. Using the noneverted explained gallbladder of the rabbit and the guinea pig, the transport of luminal to serosal fluid has been quantitated before, during, and after stone formation. The everted gallbladder preparation of the rabbit has also been used to measure fluid transport before and during gallstone formation. In both models, an increased fluid transport was observed in the phase of gallstone induction and a return to normal after stones were formed. This abnormality preceded the appearance of conventional histological features of cholecystitis. There was also a coincidental increase in glycoprotein production from and cell proliferation of the gallbladder epithelium. This enhancement of fluid transfer may play a contributing role in the genesis of gallstones.
Persistent Identifierhttp://hdl.handle.net/10722/175602
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:00:06Z-
dc.date.available2012-11-26T09:00:06Z-
dc.date.issued1978en_US
dc.identifier.citationThe American Journal Of Physiology, 1978, v. 234 n. 6, p. E575-578en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/175602-
dc.description.abstractFluid transport of the gallbladder has been studied in two models of experimental cholelithiasis: dihydrocholesterol-induced gallstones in the rabbit and lincomycin-induced gallstones in the guinea pig. Using the noneverted explained gallbladder of the rabbit and the guinea pig, the transport of luminal to serosal fluid has been quantitated before, during, and after stone formation. The everted gallbladder preparation of the rabbit has also been used to measure fluid transport before and during gallstone formation. In both models, an increased fluid transport was observed in the phase of gallstone induction and a return to normal after stones were formed. This abnormality preceded the appearance of conventional histological features of cholecystitis. There was also a coincidental increase in glycoprotein production from and cell proliferation of the gallbladder epithelium. This enhancement of fluid transfer may play a contributing role in the genesis of gallstones.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Fluids - Metabolismen_US
dc.subject.meshCholelithiasis - Chemically Induced - Etiology - Metabolismen_US
dc.subject.meshCholestanolen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder - Metabolismen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshLincomycinen_US
dc.subject.meshMaleen_US
dc.subject.meshMucous Membrane - Metabolismen_US
dc.subject.meshRabbitsen_US
dc.subject.meshTime Factorsen_US
dc.titleEnhanced fluid transport across gallbladder mucosa in experimental cholelithiasis.en_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid352156-
dc.identifier.scopuseid_2-s2.0-0017979822en_US
dc.identifier.volume234en_US
dc.identifier.issue6en_US
dc.identifier.spageE575en_US
dc.identifier.epage578en_US
dc.identifier.isiWOS:A1978FF74500006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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