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Article: The common genetic liability between schizophrenia and bipolar disorder: a review.

TitleThe common genetic liability between schizophrenia and bipolar disorder: a review.
Authors
Issue Date2001
PublisherCurrent Science Inc. The Journal's web site is located at http://www.biomedcentral.com/1523-3812
Citation
Current Psychiatry Reports, 2001, v. 3 n. 4, p. 332-337 How to Cite?
AbstractCurrent psychiatric nosology, strongly influenced by Kraepelin's dichotomy, classifies schizophrenia and bipolar disorder as separate diagnostic categories. However, growing evidence indicates that the two disorders may be more closely related than was thought in the past. Bipolar disorder and schizophrenia display considerable overlap in epidemiologic features; no risk factor is known to be specific to either. Furthermore, family studies reveal familial co-aggregation of the two disorders, and twin studies suggest a significant overlap in the genes contributing to schizophrenia, schizoaffective disorder, and mania. Finally, despite the difficulties in the identification of convincing genetic loci for psychiatric disorders, there are at least four genomic regions in which linkage has been shown for both schizophrenia and bipolar disorder. Thus, recent evidence increasingly supports a dimensional approach in the understanding of the functional psychoses, and this is expected to have implications for etiologic research and future clinical treatment.
Persistent Identifierhttp://hdl.handle.net/10722/175593
ISSN
2015 Impact Factor: 2.858
2015 SCImago Journal Rankings: 1.320

 

DC FieldValueLanguage
dc.contributor.authorBramon, Een_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2012-11-26T09:00:03Z-
dc.date.available2012-11-26T09:00:03Z-
dc.date.issued2001en_US
dc.identifier.citationCurrent Psychiatry Reports, 2001, v. 3 n. 4, p. 332-337en_US
dc.identifier.issn1523-3812en_US
dc.identifier.urihttp://hdl.handle.net/10722/175593-
dc.description.abstractCurrent psychiatric nosology, strongly influenced by Kraepelin's dichotomy, classifies schizophrenia and bipolar disorder as separate diagnostic categories. However, growing evidence indicates that the two disorders may be more closely related than was thought in the past. Bipolar disorder and schizophrenia display considerable overlap in epidemiologic features; no risk factor is known to be specific to either. Furthermore, family studies reveal familial co-aggregation of the two disorders, and twin studies suggest a significant overlap in the genes contributing to schizophrenia, schizoaffective disorder, and mania. Finally, despite the difficulties in the identification of convincing genetic loci for psychiatric disorders, there are at least four genomic regions in which linkage has been shown for both schizophrenia and bipolar disorder. Thus, recent evidence increasingly supports a dimensional approach in the understanding of the functional psychoses, and this is expected to have implications for etiologic research and future clinical treatment.en_US
dc.languageengen_US
dc.publisherCurrent Science Inc. The Journal's web site is located at http://www.biomedcentral.com/1523-3812en_US
dc.relation.ispartofCurrent psychiatry reportsen_US
dc.subject.meshBipolar Disorder - Geneticsen_US
dc.subject.meshGene Expression - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshTwin Studies As Topicen_US
dc.subject.meshTwins - Psychologyen_US
dc.titleThe common genetic liability between schizophrenia and bipolar disorder: a review.en_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11470041-
dc.identifier.scopuseid_2-s2.0-0002616202en_US
dc.identifier.volume3en_US
dc.identifier.issue4en_US
dc.identifier.spage332en_US
dc.identifier.epage337en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US

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