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Article: A time-of-flight flow sensor for the volume measurement of trace amount of interstitial fluid

TitleA time-of-flight flow sensor for the volume measurement of trace amount of interstitial fluid
Authors
Issue Date2012
PublisherInstitute of Physics Publishing. The Journal's web site is located at http://www.iop.org/journals/jmm
Citation
Journal Of Micromechanics And Microengineering, 2012, v. 22 n. 5, article no. 055009 How to Cite?
AbstractTransdermal extraction of interstitial fluid (ISF) offers an attractive method for noninvasive blood glucose monitoring. The existing macroscale systems are not suitable for ISF collection, mainly because of the minute volume of the transdermally extracted ISF which scatters on the skin surface. Human skin's low permeability to glucose and its varying permeability exemplify the crucial need to make precise ISF volume measurements in order to calculate blood glucose concentrations accurately. In this paper, we present a novel time-of-flight flow sensor consisting of four electrode pairs fabricated directly into the channel of a polydimethylsiloxane (PDMS) microfluidic device designed to accurately measure the volume of transdermally extracted ISF. As fluid traverses the channel, it bridges each electrode pair and changes its resistance. By measuring the time difference in resistance change between each electrode pair, a precise fluid volume can be measured. In order to verify the suitability of the sensor for biological applications, experiments were conducted using a normal saline solution which is similar to ISF. The stability of the sensor was tested using a fixed volume, and the coefficient of variation for 20 tests was determined to be 0.0041. The consistency of the sensor for varied volume measurements was shown by the high correlation coefficient (R 2= 0.9992) between the tested volume and the volume measured by a commercial micro syringe. The excellent functionality of the flow sensor can be extended toward the measurement of conductive chemical and biochemical buffers and reagents. © 2012 IOP Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/175545
ISSN
2015 Impact Factor: 1.768
2015 SCImago Journal Rankings: 0.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, Hen_HK
dc.contributor.authorLi, Den_HK
dc.contributor.authorRoberts, RCen_HK
dc.contributor.authorXu, Ken_HK
dc.contributor.authorTien, NCen_HK
dc.date.accessioned2012-11-26T08:59:27Z-
dc.date.available2012-11-26T08:59:27Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Micromechanics And Microengineering, 2012, v. 22 n. 5, article no. 055009en_HK
dc.identifier.issn0960-1317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/175545-
dc.description.abstractTransdermal extraction of interstitial fluid (ISF) offers an attractive method for noninvasive blood glucose monitoring. The existing macroscale systems are not suitable for ISF collection, mainly because of the minute volume of the transdermally extracted ISF which scatters on the skin surface. Human skin's low permeability to glucose and its varying permeability exemplify the crucial need to make precise ISF volume measurements in order to calculate blood glucose concentrations accurately. In this paper, we present a novel time-of-flight flow sensor consisting of four electrode pairs fabricated directly into the channel of a polydimethylsiloxane (PDMS) microfluidic device designed to accurately measure the volume of transdermally extracted ISF. As fluid traverses the channel, it bridges each electrode pair and changes its resistance. By measuring the time difference in resistance change between each electrode pair, a precise fluid volume can be measured. In order to verify the suitability of the sensor for biological applications, experiments were conducted using a normal saline solution which is similar to ISF. The stability of the sensor was tested using a fixed volume, and the coefficient of variation for 20 tests was determined to be 0.0041. The consistency of the sensor for varied volume measurements was shown by the high correlation coefficient (R 2= 0.9992) between the tested volume and the volume measured by a commercial micro syringe. The excellent functionality of the flow sensor can be extended toward the measurement of conductive chemical and biochemical buffers and reagents. © 2012 IOP Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherInstitute of Physics Publishing. The Journal's web site is located at http://www.iop.org/journals/jmmen_HK
dc.relation.ispartofJournal of Micromechanics and Microengineeringen_HK
dc.titleA time-of-flight flow sensor for the volume measurement of trace amount of interstitial fluiden_HK
dc.typeArticleen_HK
dc.identifier.emailRoberts, RC: rcr8@hku.hken_HK
dc.identifier.emailTien, NC: nctien@hku.hken_HK
dc.identifier.authorityRoberts, RC=rp01738en_HK
dc.identifier.authorityTien, NC=rp01604en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1088/0960-1317/22/5/055009en_HK
dc.identifier.scopuseid_2-s2.0-84860491098en_HK
dc.identifier.hkuros222874-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860491098&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue5en_HK
dc.identifier.eissn1361-6439-
dc.identifier.isiWOS:000303197000009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYu, H=16240359300en_HK
dc.identifier.scopusauthoridLi, D=8432738800en_HK
dc.identifier.scopusauthoridRoberts, RC=24466830100en_HK
dc.identifier.scopusauthoridXu, K=7403282051en_HK
dc.identifier.scopusauthoridTien, NC=7006532826en_HK

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