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Article: Determination of ziprasidone hydrochloride by RP-HPLC with UV detection

TitleDetermination of ziprasidone hydrochloride by RP-HPLC with UV detection
Authors
KeywordsHigh Performance Liquid Chromatography
Quantitative Analysis
Ziprasidone Hydrochloride
Issue Date2004
Citation
Fudan University Journal Of Medical Sciences, 2004, v. 31 n. 6, p. 656-657 How to Cite?
AbstractPurpose: To establish an RP-HPLC method for the determination of Ziprasidone hydrochloride. Methods: A C18 (4.6 mm x 150 mm, 5 μm) column was adopted as stationary phase, Methanol-50 mmol/L sodium acetate solution (adjustment of pH to 6.0 with acetic acid) (75:25, V/V) was used as mobile phase, the flow rate was 1.2 mL/min, the detection wavelength was 254 nm, and the temperature of column was 25°C. Results: The limit of detection for Ziprasidone hydrochloride was 10.10 ng, the linearity was good at the range of 1.010-1010 μg/mL, R = 1.000. The intra-day and inter-day RSD of ziprasidone hydrochloride were both lower than 2%. Conclusions: The established method was simple, sensitive and accurate,and can be used for the determination and quality control of ziprasidone hydrochloride.
Persistent Identifierhttp://hdl.handle.net/10722/174921
ISSN
2015 SCImago Journal Rankings: 0.105
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Nen_US
dc.contributor.authorShen, Sen_US
dc.contributor.authorZhong, Yen_US
dc.contributor.authorWang, ZYen_US
dc.contributor.authorYu, YQen_US
dc.date.accessioned2012-11-26T08:48:08Z-
dc.date.available2012-11-26T08:48:08Z-
dc.date.issued2004en_US
dc.identifier.citationFudan University Journal Of Medical Sciences, 2004, v. 31 n. 6, p. 656-657en_US
dc.identifier.issn1672-8467en_US
dc.identifier.urihttp://hdl.handle.net/10722/174921-
dc.description.abstractPurpose: To establish an RP-HPLC method for the determination of Ziprasidone hydrochloride. Methods: A C18 (4.6 mm x 150 mm, 5 μm) column was adopted as stationary phase, Methanol-50 mmol/L sodium acetate solution (adjustment of pH to 6.0 with acetic acid) (75:25, V/V) was used as mobile phase, the flow rate was 1.2 mL/min, the detection wavelength was 254 nm, and the temperature of column was 25°C. Results: The limit of detection for Ziprasidone hydrochloride was 10.10 ng, the linearity was good at the range of 1.010-1010 μg/mL, R = 1.000. The intra-day and inter-day RSD of ziprasidone hydrochloride were both lower than 2%. Conclusions: The established method was simple, sensitive and accurate,and can be used for the determination and quality control of ziprasidone hydrochloride.en_US
dc.languageengen_US
dc.relation.ispartofFudan University Journal of Medical Sciencesen_US
dc.subjectHigh Performance Liquid Chromatographyen_US
dc.subjectQuantitative Analysisen_US
dc.subjectZiprasidone Hydrochlorideen_US
dc.titleDetermination of ziprasidone hydrochloride by RP-HPLC with UV detectionen_US
dc.typeArticleen_US
dc.identifier.emailShen, S: sshen@hkucc.hku.hken_US
dc.identifier.authorityShen, S=rp00775en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-12344249759en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12344249759&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue6en_US
dc.identifier.spage656en_US
dc.identifier.epage657en_US
dc.identifier.scopusauthoridLi, N=27170796800en_US
dc.identifier.scopusauthoridShen, S=7403431266en_US
dc.identifier.scopusauthoridZhong, Y=36488828400en_US
dc.identifier.scopusauthoridWang, ZY=8583246400en_US
dc.identifier.scopusauthoridYu, YQ=8572872900en_US

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