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postgraduate thesis: Maximum likelihood estimation of parameters with constraints in normaland multinomial distributions

TitleMaximum likelihood estimation of parameters with constraints in normaland multinomial distributions
Authors
Advisors
Advisor(s):Ng, KWTian, G
Issue Date2012
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Xue, H. [薛惠天]. (2012). Maximum likelihood estimation of parameters with constraints in normal and multinomial distributions. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4785001
AbstractMotivated by problems in medicine, biology, engineering and economics, con- strained parameter problems arise in a wide variety of applications. Among them the application to the dose-response of a certain drug in development has attracted much interest. To investigate such a relationship, we often need to conduct a dose- response experiment with multiple groups associated with multiple dose levels of the drug. The dose-response relationship can be modeled by a shape-restricted normal regression. We develop an iterative two-step ascent algorithm to estimate normal means and variances subject to simultaneous constraints. Each iteration consists of two parts: an expectation{maximization (EM) algorithm that is utilized in Step 1 to compute the maximum likelihood estimates (MLEs) of the restricted means when variances are given, and a newly developed restricted De Pierro algorithm that is used in Step 2 to find the MLEs of the restricted variances when means are given. These constraints include the simple order, tree order, umbrella order, and so on. A bootstrap approach is provided to calculate standard errors of the restricted MLEs. Applications to the analysis of two real datasets on radioim-munological assay of cortisol and bioassay of peptides are presented to illustrate the proposed methods. Liu (2000) discussed the maximum likelihood estimation and Bayesian estimation in a multinomial model with simplex constraints by formulating this constrained parameter problem into an unconstrained parameter problem in the framework of missing data. To utilize the EM and data augmentation (DA) algorithms, he introduced latent variables {Zil;Yil} (to be defined later). However, the proposed DA algorithm in his paper did not provide the necessary individual conditional distributions of Yil given (the observed data and) the updated parameter estimates. Indeed, the EM algorithm developed in his paper is based on the assumption that{ Yil} are fixed given values. Fortunately, the EM algorithm is invariant under any choice of the value of Yil, so the final result is always correct. We have derived the aforesaid conditional distributions and hence provide a valid DA algorithm. A real data set is used for illustration.
DegreeMaster of Philosophy
SubjectEstimation theory.
Parameter estimation.
Dept/ProgramStatistics and Actuarial Science

 

DC FieldValueLanguage
dc.contributor.advisorNg, KW-
dc.contributor.advisorTian, G-
dc.contributor.authorXue, Huitian.-
dc.contributor.author薛惠天.-
dc.date.issued2012-
dc.identifier.citationXue, H. [薛惠天]. (2012). Maximum likelihood estimation of parameters with constraints in normal and multinomial distributions. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4785001-
dc.description.abstractMotivated by problems in medicine, biology, engineering and economics, con- strained parameter problems arise in a wide variety of applications. Among them the application to the dose-response of a certain drug in development has attracted much interest. To investigate such a relationship, we often need to conduct a dose- response experiment with multiple groups associated with multiple dose levels of the drug. The dose-response relationship can be modeled by a shape-restricted normal regression. We develop an iterative two-step ascent algorithm to estimate normal means and variances subject to simultaneous constraints. Each iteration consists of two parts: an expectation{maximization (EM) algorithm that is utilized in Step 1 to compute the maximum likelihood estimates (MLEs) of the restricted means when variances are given, and a newly developed restricted De Pierro algorithm that is used in Step 2 to find the MLEs of the restricted variances when means are given. These constraints include the simple order, tree order, umbrella order, and so on. A bootstrap approach is provided to calculate standard errors of the restricted MLEs. Applications to the analysis of two real datasets on radioim-munological assay of cortisol and bioassay of peptides are presented to illustrate the proposed methods. Liu (2000) discussed the maximum likelihood estimation and Bayesian estimation in a multinomial model with simplex constraints by formulating this constrained parameter problem into an unconstrained parameter problem in the framework of missing data. To utilize the EM and data augmentation (DA) algorithms, he introduced latent variables {Zil;Yil} (to be defined later). However, the proposed DA algorithm in his paper did not provide the necessary individual conditional distributions of Yil given (the observed data and) the updated parameter estimates. Indeed, the EM algorithm developed in his paper is based on the assumption that{ Yil} are fixed given values. Fortunately, the EM algorithm is invariant under any choice of the value of Yil, so the final result is always correct. We have derived the aforesaid conditional distributions and hence provide a valid DA algorithm. A real data set is used for illustration.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.source.urihttp://hub.hku.hk/bib/B47850012-
dc.subject.lcshEstimation theory.-
dc.subject.lcshParameter estimation.-
dc.titleMaximum likelihood estimation of parameters with constraints in normaland multinomial distributions-
dc.typePG_Thesis-
dc.identifier.hkulb4785001-
dc.description.thesisnameMaster of Philosophy-
dc.description.thesislevelMaster-
dc.description.thesisdisciplineStatistics and Actuarial Science-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5353/th_b4785001-
dc.date.hkucongregation2012-

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