File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Neuropsychiatric symptoms are associated with increased risks of progression to dementia: A 2-year prospective study of 321 Chinese older persons with mild cognitive impairment

TitleNeuropsychiatric symptoms are associated with increased risks of progression to dementia: A 2-year prospective study of 321 Chinese older persons with mild cognitive impairment
Authors
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://ageing.oxfordjournals.org/
Citation
Age And Ageing, 2011, v. 40 n. 1, p. 30-35 How to Cite?
AbstractBackground: studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples. Objective: to explore the association between NP symptoms and risk of cognitive decline in Chinese older persons residing in the community. Design: prospective study. Setting: community sample. Subjects: a total of 321 community-dwelling Chinese older persons aged 60 or over with mild cognitive impairment participated in the study. Methods: at baseline, each subject was assessed with Clinical Dementia Rating (CDR), Mini-Mental State Examination, list learning and delayed recall, and Category Verbal Fluency Test. Severity of NP symptoms was evaluated with Neuropsychiatric Inventory (NPI). Global cognitive status at the end of 2-year study period was determined by CDR. Results: at baseline, 40.5% of participants exhibited one or more NP symptoms (NPI total score ≥1). Night-time behaviours (22.1%), depression (16.8%), apathy (14.0%) and anxiety (12.8%) were the most common NP symptoms. At the end of 2-year follow-up, 27.5% of participants with depression at baseline developed dementia, compared with 14.8% of those without depression (χ 2=4.90, P= 0.03). Aberrant motor behaviour was also significantly associated with deterioration in cognition (χ 2= 5.84, P= 0.02), although it was an infrequent occurrence. On logistic regression analysis, only depression at baseline was shown to be a risk factor for progression to dementia (OR= 2.40, 95% CI 1.05-5.46, P= 0.04). Conclusion: depression in non-demented older persons may represent an independent dimension reflecting early neuronal degeneration. Further studies should be conducted to assess whether effective management of NP symptoms exerts beneficial effects on cognitive function. © The Author 2010. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/174247
ISSN
2015 Impact Factor: 4.201
2015 SCImago Journal Rankings: 1.611
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, WCen_US
dc.contributor.authorLam, LCWen_US
dc.contributor.authorTam, CWCen_US
dc.contributor.authorLui, VWCen_US
dc.contributor.authorLeung, GTYen_US
dc.contributor.authorLee, ATCen_US
dc.contributor.authorChan, SSMen_US
dc.contributor.authorFung, AWTen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorChan, WMen_US
dc.date.accessioned2012-11-22T02:01:35Z-
dc.date.available2012-11-22T02:01:35Z-
dc.date.issued2011en_US
dc.identifier.citationAge And Ageing, 2011, v. 40 n. 1, p. 30-35en_US
dc.identifier.issn0002-0729en_US
dc.identifier.urihttp://hdl.handle.net/10722/174247-
dc.description.abstractBackground: studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples. Objective: to explore the association between NP symptoms and risk of cognitive decline in Chinese older persons residing in the community. Design: prospective study. Setting: community sample. Subjects: a total of 321 community-dwelling Chinese older persons aged 60 or over with mild cognitive impairment participated in the study. Methods: at baseline, each subject was assessed with Clinical Dementia Rating (CDR), Mini-Mental State Examination, list learning and delayed recall, and Category Verbal Fluency Test. Severity of NP symptoms was evaluated with Neuropsychiatric Inventory (NPI). Global cognitive status at the end of 2-year study period was determined by CDR. Results: at baseline, 40.5% of participants exhibited one or more NP symptoms (NPI total score ≥1). Night-time behaviours (22.1%), depression (16.8%), apathy (14.0%) and anxiety (12.8%) were the most common NP symptoms. At the end of 2-year follow-up, 27.5% of participants with depression at baseline developed dementia, compared with 14.8% of those without depression (χ 2=4.90, P= 0.03). Aberrant motor behaviour was also significantly associated with deterioration in cognition (χ 2= 5.84, P= 0.02), although it was an infrequent occurrence. On logistic regression analysis, only depression at baseline was shown to be a risk factor for progression to dementia (OR= 2.40, 95% CI 1.05-5.46, P= 0.04). Conclusion: depression in non-demented older persons may represent an independent dimension reflecting early neuronal degeneration. Further studies should be conducted to assess whether effective management of NP symptoms exerts beneficial effects on cognitive function. © The Author 2010. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ageing.oxfordjournals.org/en_US
dc.relation.ispartofAge and Ageingen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChinaen_US
dc.subject.meshCognition Disorders - Complications - Diagnosis - Ethnologyen_US
dc.subject.meshDementia - Epidemiologyen_US
dc.subject.meshDepression - Complications - Diagnosis - Ethnologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve Degeneration - Complications - Diagnosis - Ethnologyen_US
dc.subject.meshNeuropsychological Testsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshRisk Factorsen_US
dc.titleNeuropsychiatric symptoms are associated with increased risks of progression to dementia: A 2-year prospective study of 321 Chinese older persons with mild cognitive impairmenten_US
dc.typeArticleen_US
dc.identifier.emailChan, WC: waicchan@hku.hken_US
dc.identifier.authorityChan, WC=rp01687en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/ageing/afq151en_US
dc.identifier.pmid21106558-
dc.identifier.scopuseid_2-s2.0-78650412162en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650412162&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume40en_US
dc.identifier.issue1en_US
dc.identifier.spage30en_US
dc.identifier.epage35en_US
dc.identifier.isiWOS:000285191700007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, WC=16400525900en_US
dc.identifier.scopusauthoridLam, LCW=7201984627en_US
dc.identifier.scopusauthoridTam, CWC=26021559000en_US
dc.identifier.scopusauthoridLui, VWC=9245605300en_US
dc.identifier.scopusauthoridLeung, GTY=22980588600en_US
dc.identifier.scopusauthoridLee, ATC=7405628178en_US
dc.identifier.scopusauthoridChan, SSM=13409371900en_US
dc.identifier.scopusauthoridFung, AWT=22934304800en_US
dc.identifier.scopusauthoridChiu, HFK=24447976700en_US
dc.identifier.scopusauthoridChan, WM=7403914485en_US
dc.identifier.citeulike8466156-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats