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Article: Prevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-A population-based study

TitlePrevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-A population-based study
Authors
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://ajgp.psychiatryonline.org/
Citation
American Journal Of Geriatric Psychiatry, 2010, v. 18 n. 10, p. 948-954 How to Cite?
AbstractObjectives: To estimate the point prevalence and correlates of neuropsychiatric (NP) symptoms among older adults with mild cognitive impairment (MCI) and normal cognition (NC) in a Chinese community. Design: Cross-sectional study derived from a population-based prevalence study of MCI and dementia. Setting and Participants: This survey was conducted in Hong Kong from 2005 to 2006. Seven hundred eighty-eight community-dwelling older adults (450 NC and 338 MCI) were recruited. Cognitive and NP data were obtained. Results: The point prevalence of at least one NP symptom in NC and MCI were 29% and 36.7%, respectively (logistic regression controlled for age and education, odds ratio = 1.38, 95% confidence interval [CI]: 1.01-1.89, Wald χ = 4.10, df = 1, p = 0.04). Agitation (1.8% versus 5.1%), apathy (7.6% versus 15.2%), and irritability (4.2% versus 8%) were more prevalent in subjects with MCI (p <0.05). Logistic regression analyses showed that apathy score was a significant factor associated with the status of NC or MCI (logistic regression, apathy, p = 0.031, Exp(B) = 1.23, 95% CI: 1.02-1.47; Hosmer and Lemeshow test, χ = 8.6, df = 8, p = 0.38, R = 0.23). Conclusions: The authors reported the findings of one of the first population-based studies estimating the point prevalence of NP symptoms in Asian older adults with MCI. Taking into account of its prevalence and magnitude of effects, apathy is a clinically significant symptom in MCI. Its predictive value for conversion to dementia warrants further evaluation. © 2010 American Association for Geriatric Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/174246
ISSN
2015 Impact Factor: 3.13
2015 SCImago Journal Rankings: 1.653
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, WCen_US
dc.contributor.authorLam, LCWen_US
dc.contributor.authorTam, CWCen_US
dc.contributor.authorLui, VWCen_US
dc.contributor.authorChan, SSMen_US
dc.contributor.authorChan, WMen_US
dc.contributor.authorChiu, HFKen_US
dc.date.accessioned2012-11-22T02:01:34Z-
dc.date.available2012-11-22T02:01:34Z-
dc.date.issued2010en_US
dc.identifier.citationAmerican Journal Of Geriatric Psychiatry, 2010, v. 18 n. 10, p. 948-954en_US
dc.identifier.issn1064-7481en_US
dc.identifier.urihttp://hdl.handle.net/10722/174246-
dc.description.abstractObjectives: To estimate the point prevalence and correlates of neuropsychiatric (NP) symptoms among older adults with mild cognitive impairment (MCI) and normal cognition (NC) in a Chinese community. Design: Cross-sectional study derived from a population-based prevalence study of MCI and dementia. Setting and Participants: This survey was conducted in Hong Kong from 2005 to 2006. Seven hundred eighty-eight community-dwelling older adults (450 NC and 338 MCI) were recruited. Cognitive and NP data were obtained. Results: The point prevalence of at least one NP symptom in NC and MCI were 29% and 36.7%, respectively (logistic regression controlled for age and education, odds ratio = 1.38, 95% confidence interval [CI]: 1.01-1.89, Wald χ = 4.10, df = 1, p = 0.04). Agitation (1.8% versus 5.1%), apathy (7.6% versus 15.2%), and irritability (4.2% versus 8%) were more prevalent in subjects with MCI (p <0.05). Logistic regression analyses showed that apathy score was a significant factor associated with the status of NC or MCI (logistic regression, apathy, p = 0.031, Exp(B) = 1.23, 95% CI: 1.02-1.47; Hosmer and Lemeshow test, χ = 8.6, df = 8, p = 0.38, R = 0.23). Conclusions: The authors reported the findings of one of the first population-based studies estimating the point prevalence of NP symptoms in Asian older adults with MCI. Taking into account of its prevalence and magnitude of effects, apathy is a clinically significant symptom in MCI. Its predictive value for conversion to dementia warrants further evaluation. © 2010 American Association for Geriatric Psychiatry.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://ajgp.psychiatryonline.org/en_US
dc.relation.ispartofAmerican Journal of Geriatric Psychiatryen_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Group - Psychologyen_US
dc.subject.meshCognition Disorders - Complicationsen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGeriatric Assessment - Methodsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMental Disorders - Complications - Epidemiologyen_US
dc.subject.meshPrevalenceen_US
dc.titlePrevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-A population-based studyen_US
dc.typeArticleen_US
dc.identifier.emailChan, WC: waicchan@hku.hken_US
dc.identifier.authorityChan, WC=rp01687en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/JGP.0b013e3181d69467en_US
dc.identifier.pmid20808089-
dc.identifier.scopuseid_2-s2.0-77958035334en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958035334&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue10en_US
dc.identifier.spage948en_US
dc.identifier.epage954en_US
dc.identifier.isiWOS:000282128900010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, WC=16400525900en_US
dc.identifier.scopusauthoridLam, LCW=7201984627en_US
dc.identifier.scopusauthoridTam, CWC=26021559000en_US
dc.identifier.scopusauthoridLui, VWC=9245605300en_US
dc.identifier.scopusauthoridChan, SSM=13409371900en_US
dc.identifier.scopusauthoridChan, WM=7403914485en_US
dc.identifier.scopusauthoridChiu, HFK=7401986628en_US

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