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Article: Screening of mild cognitive impairment in Chinese older adults - A multistage validation of the Chinese abbreviated mild cognitive impairment test

TitleScreening of mild cognitive impairment in Chinese older adults - A multistage validation of the Chinese abbreviated mild cognitive impairment test
Authors
Issue Date2008
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NED
Citation
Neuroepidemiology, 2008, v. 30 n. 1, p. 6-12 How to Cite?
AbstractObjective: To develop a short cognitive test for screening mild cognitive impairment (MCI) in Hong Kong Chinese older adults. Methods: The Chinese Abbreviated MCI (CAMCI) test was developed with a multistage process. In phase 1, a short version of the cognitive test comprising a 1-min animal fluency test and a 10-min delayed word list recall was developed and tested in 578 volunteers (community-dwelling active elderly persons). In phase 2, the CAMCI test was validated in an independent and randomly recruited sample of 459 participants in a community survey. Additionally, the predictive significance of the CAMCI test was evaluated in a group of 196 subjects assessed in phase 1 for conversion to clinical dementia at 20 months' follow-up. The discriminating power of the CAMCI test in differentiating MCI from normal control (NC) and mildly demented subjects was compared with Mini Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscales. Results: The CAMCI test was found to have high discriminating power in differentiating NC from MCI and mildly demented subjects in the phase 1 volunteer sample. The receiver operating characteristics (ROC) revealed an area under the curve (AUC) of 0.91. The ROC were further validated in the phase 2 sample. The AUC of the CAMCI test was compared with MMSE and ADAS-Cog subscales. The short MCI test was comparable to the ADAS-Cog subscale in discriminating NC from MCI and demented subjects (χ 2 test, p = n.s.). Logistic regression analysis was carried out to determine significant baseline predictors for conversion to dementia at phase 3 follow-up. Both ADAS-Cog total [Exp(B) = 1.115, p = 0.028] and CAMCI [Exp(B) = 0.88, p = 0.045] scores were significant predictors for dementia status at follow-up. Conclusion: The CAMCI test is able to discriminate NC from MCI and mild dementia in Hong Kong Chinese older adults. Its potential for large-scale community screening for early detection of cognitive impairment in late life should be emphasized and explored. Copyright © 2008 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/174239
ISSN
2015 Impact Factor: 2.784
2015 SCImago Journal Rankings: 1.726
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, LCWen_US
dc.contributor.authorTam, CWCen_US
dc.contributor.authorLui, VWCen_US
dc.contributor.authorChan, WCen_US
dc.contributor.authorChan, SSMen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorLeung, Ten_US
dc.contributor.authorTham, MKen_US
dc.contributor.authorHo, KSen_US
dc.contributor.authorChan, WMen_US
dc.date.accessioned2012-11-22T02:01:29Z-
dc.date.available2012-11-22T02:01:29Z-
dc.date.issued2008en_US
dc.identifier.citationNeuroepidemiology, 2008, v. 30 n. 1, p. 6-12en_US
dc.identifier.issn0251-5350en_US
dc.identifier.urihttp://hdl.handle.net/10722/174239-
dc.description.abstractObjective: To develop a short cognitive test for screening mild cognitive impairment (MCI) in Hong Kong Chinese older adults. Methods: The Chinese Abbreviated MCI (CAMCI) test was developed with a multistage process. In phase 1, a short version of the cognitive test comprising a 1-min animal fluency test and a 10-min delayed word list recall was developed and tested in 578 volunteers (community-dwelling active elderly persons). In phase 2, the CAMCI test was validated in an independent and randomly recruited sample of 459 participants in a community survey. Additionally, the predictive significance of the CAMCI test was evaluated in a group of 196 subjects assessed in phase 1 for conversion to clinical dementia at 20 months' follow-up. The discriminating power of the CAMCI test in differentiating MCI from normal control (NC) and mildly demented subjects was compared with Mini Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscales. Results: The CAMCI test was found to have high discriminating power in differentiating NC from MCI and mildly demented subjects in the phase 1 volunteer sample. The receiver operating characteristics (ROC) revealed an area under the curve (AUC) of 0.91. The ROC were further validated in the phase 2 sample. The AUC of the CAMCI test was compared with MMSE and ADAS-Cog subscales. The short MCI test was comparable to the ADAS-Cog subscale in discriminating NC from MCI and demented subjects (χ 2 test, p = n.s.). Logistic regression analysis was carried out to determine significant baseline predictors for conversion to dementia at phase 3 follow-up. Both ADAS-Cog total [Exp(B) = 1.115, p = 0.028] and CAMCI [Exp(B) = 0.88, p = 0.045] scores were significant predictors for dementia status at follow-up. Conclusion: The CAMCI test is able to discriminate NC from MCI and mild dementia in Hong Kong Chinese older adults. Its potential for large-scale community screening for early detection of cognitive impairment in late life should be emphasized and explored. Copyright © 2008 S. Karger AG.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEDen_US
dc.relation.ispartofNeuroepidemiologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshArea Under Curveen_US
dc.subject.meshCognition Disorders - Diagnosis - Epidemiologyen_US
dc.subject.meshDementia - Diagnosis - Epidemiologyen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGeriatric Assessment - Methods - Statistics & Numerical Dataen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screening - Methodsen_US
dc.subject.meshMental Recallen_US
dc.subject.meshNeuropsychological Tests - Standards - Statistics & Numerical Dataen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshRoc Curveen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshTask Performance And Analysisen_US
dc.titleScreening of mild cognitive impairment in Chinese older adults - A multistage validation of the Chinese abbreviated mild cognitive impairment testen_US
dc.typeArticleen_US
dc.identifier.emailChan, WC: waicchan@hku.hken_US
dc.identifier.authorityChan, WC=rp01687en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000113300en_US
dc.identifier.pmid18204291-
dc.identifier.scopuseid_2-s2.0-39749099313en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39749099313&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue1en_US
dc.identifier.spage6en_US
dc.identifier.epage12en_US
dc.identifier.isiWOS:000253247100003-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLam, LCW=7201984627en_US
dc.identifier.scopusauthoridTam, CWC=26021559000en_US
dc.identifier.scopusauthoridLui, VWC=9245605300en_US
dc.identifier.scopusauthoridChan, WC=16400525900en_US
dc.identifier.scopusauthoridChan, SSM=13409371900en_US
dc.identifier.scopusauthoridChiu, HFK=24447976700en_US
dc.identifier.scopusauthoridLeung, T=15739768600en_US
dc.identifier.scopusauthoridTham, MK=16679910000en_US
dc.identifier.scopusauthoridHo, KS=7403581605en_US
dc.identifier.scopusauthoridChan, WM=7403914485en_US

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