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Postgraduate Thesis: Mother-to-child-transmission (MTCT) of human immunodeficiency virus (HIV) in designated hospital in Hong Kong
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TitleMother-to-child-transmission (MTCT) of human immunodeficiency virus (HIV) in designated hospital in Hong Kong
 
AuthorsChan, Wai-hung
陳偉雄
 
Issue Date2011
 
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
AbstractBackground: Mother-To-Child-Transmission (MTCT) of Human Immunodeficiency Virus (HIV) infection in developed countries are by and large lowered to very low level by preventive and prophylactic measures including antenatal universal screening of HIV antibody in pregnant women, antiretroviral prophylaxis, elective caesarean sections and avoidance of breast feeding after birth. The exact MTCT rate after commencement of the above prophylactic measures in Hong Kong remains uncertain. Objective: To determine the MTCT rate of a designated hospital taking care of people living with HIV or Acquired Immunodeficiency Syndrome (AIDS) in Hong Kong and to study the potential side effects and toxicity of antiretroviral prophylaxis given in antenatal, intrapartum and postnatal period in newborns born from HIV infected mothers in the designated hospital. Methods: Retrospective descriptive study of all newborns born from HIV infected mothers during the period of 1st January 2002 to 31st December 2010 in the designated hospital was conducted. Results: Total 17 infants born from HIV infected mothers are identified. It consists of 31.5% of total number of infants born from HIV infected mothers in Hong Kong. Only 1 was diagnosed to have HIV infection at 4 months of age. Hence, the MTCT rate is 5.9% in the designated hospital. Serial haemoglobin (Hb) levels and liver function (LFT) at birth of all infants; lactate only when infants develop symptoms indicating neurologic involvement are recorded. Only the Hb levels at birth are moderately lower than normal which indicate mild transient marrow toxicity. Conclusions: The MTCT rate in a designated hospital in Hong Kong is approaching the rate in developed countries after commencement of various preventive and prophylactic measures for prevention of MTCT in HIV infected mothers. No significant persistent toxicity of antiretroviral prophylaxis exposure during antenatal, intrapartum and postnatal period in infants born from HIV infected mothers is identified. However, prolonged follow up for potential long term teratogenic and carcinogenic effect is still suggested for such exposure.
 
DescriptionThesis (P. Dip.)--University of Hong Kong, 2012.
"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
Includes bibliographical references (p. 22-26).
 
DegreePostgraduate Diploma in Infectious Diseases
 
SubjectHIV (Viruses) -- Transmission -- China -- Hong Kong.
AIDS (Disease) -- Transmission -- China -- Hong Kong.
HIV-positive women -- China -- Hong Kong.
AIDS (Disease) in infants -- China -- Hong Kong.
 
Dept/ProgramMicrobiology
 
DC FieldValue
dc.contributor.authorChan, Wai-hung
 
dc.contributor.author陳偉雄
 
dc.date.accessioned2012-11-01T02:50:34Z
 
dc.date.available2012-11-01T02:50:34Z
 
dc.date.issued2011
 
dc.description.abstractBackground: Mother-To-Child-Transmission (MTCT) of Human Immunodeficiency Virus (HIV) infection in developed countries are by and large lowered to very low level by preventive and prophylactic measures including antenatal universal screening of HIV antibody in pregnant women, antiretroviral prophylaxis, elective caesarean sections and avoidance of breast feeding after birth. The exact MTCT rate after commencement of the above prophylactic measures in Hong Kong remains uncertain. Objective: To determine the MTCT rate of a designated hospital taking care of people living with HIV or Acquired Immunodeficiency Syndrome (AIDS) in Hong Kong and to study the potential side effects and toxicity of antiretroviral prophylaxis given in antenatal, intrapartum and postnatal period in newborns born from HIV infected mothers in the designated hospital. Methods: Retrospective descriptive study of all newborns born from HIV infected mothers during the period of 1st January 2002 to 31st December 2010 in the designated hospital was conducted. Results: Total 17 infants born from HIV infected mothers are identified. It consists of 31.5% of total number of infants born from HIV infected mothers in Hong Kong. Only 1 was diagnosed to have HIV infection at 4 months of age. Hence, the MTCT rate is 5.9% in the designated hospital. Serial haemoglobin (Hb) levels and liver function (LFT) at birth of all infants; lactate only when infants develop symptoms indicating neurologic involvement are recorded. Only the Hb levels at birth are moderately lower than normal which indicate mild transient marrow toxicity. Conclusions: The MTCT rate in a designated hospital in Hong Kong is approaching the rate in developed countries after commencement of various preventive and prophylactic measures for prevention of MTCT in HIV infected mothers. No significant persistent toxicity of antiretroviral prophylaxis exposure during antenatal, intrapartum and postnatal period in infants born from HIV infected mothers is identified. However, prolonged follow up for potential long term teratogenic and carcinogenic effect is still suggested for such exposure.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionThesis (P. Dip.)--University of Hong Kong, 2012.
 
dc.description"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
 
dc.descriptionIncludes bibliographical references (p. 22-26).
 
dc.description.thesisdisciplineMicrobiology
 
dc.description.thesislevelPostgraduate diploma
 
dc.description.thesisnamePostgraduate Diploma in Infectious Diseases
 
dc.identifier.hkulb4832063
 
dc.identifier.urihttp://hdl.handle.net/10722/173743
 
dc.languageeng
 
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.
 
dc.subject.lcshHIV (Viruses) -- Transmission -- China -- Hong Kong.
 
dc.subject.lcshAIDS (Disease) -- Transmission -- China -- Hong Kong.
 
dc.subject.lcshHIV-positive women -- China -- Hong Kong.
 
dc.subject.lcshAIDS (Disease) in infants -- China -- Hong Kong.
 
dc.titleMother-to-child-transmission (MTCT) of human immunodeficiency virus (HIV) in designated hospital in Hong Kong
 
dc.typePG_Thesis
 
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<item><contributor.author>Chan, Wai-hung</contributor.author>
<contributor.author>&#38515;&#20553;&#38596;</contributor.author>
<date.accessioned>2012-11-01T02:50:34Z</date.accessioned>
<date.available>2012-11-01T02:50:34Z</date.available>
<date.issued>2011</date.issued>
<identifier.uri>http://hdl.handle.net/10722/173743</identifier.uri>
<description>Thesis (P. Dip.)--University of Hong Kong, 2012.</description>
<description>&quot;This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK).&quot;</description>
<description>Includes bibliographical references (p. 22-26).</description>
<description.abstract>Background: Mother-To-Child-Transmission (MTCT) of Human
Immunodeficiency Virus (HIV) infection in developed countries are by and large
lowered to very low level by preventive and prophylactic measures including
antenatal universal screening of HIV antibody in pregnant women, antiretroviral
prophylaxis, elective caesarean sections and avoidance of breast feeding after
birth. The exact MTCT rate after commencement of the above prophylactic
measures in Hong Kong remains uncertain.
Objective: To determine the MTCT rate of a designated hospital taking care of
people living with HIV or Acquired Immunodeficiency Syndrome (AIDS) in
Hong Kong and to study the potential side effects and toxicity of antiretroviral
prophylaxis given in antenatal, intrapartum and postnatal period in newborns
born from HIV infected mothers in the designated hospital.
Methods: Retrospective descriptive study of all newborns born from HIV
infected mothers during the period of 1st January 2002 to 31st December 2010 in
the designated hospital was conducted.
Results: Total 17 infants born from HIV infected mothers are identified. It
consists of 31.5% of total number of infants born from HIV infected mothers in
Hong Kong. Only 1 was diagnosed to have HIV infection at 4 months of age.
Hence, the MTCT rate is 5.9% in the designated hospital. Serial haemoglobin
(Hb) levels and liver function (LFT) at birth of all infants; lactate only when
infants develop symptoms indicating neurologic involvement are recorded. Only
the Hb levels at birth are moderately lower than normal which indicate mild
transient marrow toxicity.
Conclusions: The MTCT rate in a designated hospital in Hong Kong is
approaching the rate in developed countries after commencement of various
preventive and prophylactic measures for prevention of MTCT in HIV infected
mothers. No significant persistent toxicity of antiretroviral prophylaxis exposure
during antenatal, intrapartum and postnatal period in infants born from HIV
infected mothers is identified. However, prolonged follow up for potential long
term teratogenic and carcinogenic effect is still suggested for such exposure.</description.abstract>
<language>eng</language>
<publisher>The University of Hong Kong (Pokfulam, Hong Kong)</publisher>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<rights>The author retains all proprietary rights, (such as patent rights) and the right to use in future works.</rights>
<subject.lcsh>HIV (Viruses) -- Transmission -- China -- Hong Kong.</subject.lcsh>
<subject.lcsh>AIDS (Disease) -- Transmission -- China -- Hong Kong.</subject.lcsh>
<subject.lcsh>HIV-positive women -- China -- Hong Kong.</subject.lcsh>
<subject.lcsh>AIDS (Disease) in infants -- China -- Hong Kong.</subject.lcsh>
<title>Mother-to-child-transmission (MTCT) of human immunodeficiency virus (HIV) in designated hospital in Hong Kong</title>
<type>PG_Thesis</type>
<identifier.hkul>b4832063</identifier.hkul>
<description.thesisname>Postgraduate Diploma in Infectious Diseases</description.thesisname>
<description.thesislevel>Postgraduate diploma</description.thesislevel>
<description.thesisdiscipline>Microbiology</description.thesisdiscipline>
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<bitstream.url>http://hub.hku.hk/bitstream/10722/173743/1/FullText.pdf</bitstream.url>
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