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Postgraduate Thesis: Listeriosis in Hong Kong
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TitleListeriosis in Hong Kong
 
AuthorsLam, Kwok-wai
林國偉
 
Issue Date2012
 
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
AbstractBackground Listeria monocytogenes is an uncommon but important cause of bacteremia and meningitis in Hong Kong. Our aim is to study the local epidemiology, clinical features, antibiotic susceptibility pattern and outcome of Listeriosis in Hong Kong. Methods A retrospective study was carried out in two local microbiology laboratories in Hong Kong. All patients with positive Listeria monocytogenes isolates in any clinical specimens over the past 10 years were included. Results A total of 31 patients with 41 Listeria monocytogenes isolates were identified in our series. Fever was the most common presentation (80% of patients). There were 20 cases of bacteremia, 3 cases of meningitis and 3 cases of bacteremic meningitis. In non-perinatal cases, most of the patients had underlying medical conditions. The most common associated co-morbidity was underlying malignancy. The mortality of Listeria monocytogenes infection was 24%. The stillbirth rate in pregnant women was 40%. 27% of patients were documented to have consumed dairy products or other high-risk foods. There were 2 isolates intermediate sensitivity to penicillin while all tested isolates were 100% sensitive to ampicillin, Septrin and vancomycin. Mortality was not associated with appropriate antibiotic use, use of immunosuppressants or advanced age. Conclusions Human Listeriosis is a rare but important infection in Hong Kong. It particularly affects newborns, pregnant women and immunocompromised hosts, and carries a high risk of mortality and stillbirth.
 
DescriptionThesis (P. Dip.)--University of Hong Kong, 2012.
"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
Includes bibliographical references.
 
DegreePostgraduate Diploma in Infectious Diseases
 
SubjectListeriosis -- China -- Hong Kong.
 
Dept/ProgramMicrobiology
 
DC FieldValue
dc.contributor.authorLam, Kwok-wai
 
dc.contributor.author林國偉
 
dc.date.accessioned2012-11-01T02:50:32Z
 
dc.date.available2012-11-01T02:50:32Z
 
dc.date.issued2012
 
dc.description.abstractBackground Listeria monocytogenes is an uncommon but important cause of bacteremia and meningitis in Hong Kong. Our aim is to study the local epidemiology, clinical features, antibiotic susceptibility pattern and outcome of Listeriosis in Hong Kong. Methods A retrospective study was carried out in two local microbiology laboratories in Hong Kong. All patients with positive Listeria monocytogenes isolates in any clinical specimens over the past 10 years were included. Results A total of 31 patients with 41 Listeria monocytogenes isolates were identified in our series. Fever was the most common presentation (80% of patients). There were 20 cases of bacteremia, 3 cases of meningitis and 3 cases of bacteremic meningitis. In non-perinatal cases, most of the patients had underlying medical conditions. The most common associated co-morbidity was underlying malignancy. The mortality of Listeria monocytogenes infection was 24%. The stillbirth rate in pregnant women was 40%. 27% of patients were documented to have consumed dairy products or other high-risk foods. There were 2 isolates intermediate sensitivity to penicillin while all tested isolates were 100% sensitive to ampicillin, Septrin and vancomycin. Mortality was not associated with appropriate antibiotic use, use of immunosuppressants or advanced age. Conclusions Human Listeriosis is a rare but important infection in Hong Kong. It particularly affects newborns, pregnant women and immunocompromised hosts, and carries a high risk of mortality and stillbirth.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionThesis (P. Dip.)--University of Hong Kong, 2012.
 
dc.description"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
 
dc.descriptionIncludes bibliographical references.
 
dc.description.thesisdisciplineMicrobiology
 
dc.description.thesislevelPostgraduate diploma
 
dc.description.thesisnamePostgraduate Diploma in Infectious Diseases
 
dc.identifier.hkulb4832052
 
dc.identifier.urihttp://hdl.handle.net/10722/173738
 
dc.languageeng
 
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.
 
dc.subject.lcshListeriosis -- China -- Hong Kong.
 
dc.titleListeriosis in Hong Kong
 
dc.typePG_Thesis
 
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<item><contributor.author>Lam, Kwok-wai</contributor.author>
<contributor.author>&#26519;&#22283;&#20553;</contributor.author>
<date.accessioned>2012-11-01T02:50:32Z</date.accessioned>
<date.available>2012-11-01T02:50:32Z</date.available>
<date.issued>2012</date.issued>
<identifier.uri>http://hdl.handle.net/10722/173738</identifier.uri>
<description>Thesis (P. Dip.)--University of Hong Kong, 2012.</description>
<description>&quot;This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK).&quot;</description>
<description>Includes bibliographical references.</description>
<description.abstract>Background
Listeria monocytogenes is an uncommon but important cause of bacteremia and
meningitis in Hong Kong. Our aim is to study the local epidemiology, clinical
features, antibiotic susceptibility pattern and outcome of Listeriosis in Hong Kong.
Methods
A retrospective study was carried out in two local microbiology laboratories in Hong
Kong. All patients with positive Listeria monocytogenes isolates in any clinical
specimens over the past 10 years were included.
Results
A total of 31 patients with 41 Listeria monocytogenes isolates were identified in our
series. Fever was the most common presentation (80% of patients). There were 20
cases of bacteremia, 3 cases of meningitis and 3 cases of bacteremic meningitis. In
non-perinatal cases, most of the patients had underlying medical conditions. The most
common associated co-morbidity was underlying malignancy. The mortality of
Listeria monocytogenes infection was 24%. The stillbirth rate in pregnant women was
40%. 27% of patients were documented to have consumed dairy products or other
high-risk foods. There were 2 isolates intermediate sensitivity to penicillin while all
tested isolates were 100% sensitive to ampicillin, Septrin and vancomycin. Mortality
was not associated with appropriate antibiotic use, use of immunosuppressants or
advanced age.
Conclusions
Human Listeriosis is a rare but important infection in Hong Kong. It particularly
affects newborns, pregnant women and immunocompromised hosts, and carries a high
risk of mortality and stillbirth.</description.abstract>
<language>eng</language>
<publisher>The University of Hong Kong (Pokfulam, Hong Kong)</publisher>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<rights>The author retains all proprietary rights, (such as patent rights) and the right to use in future works.</rights>
<subject.lcsh>Listeriosis -- China -- Hong Kong.</subject.lcsh>
<title>Listeriosis in Hong Kong</title>
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<description.thesisname>Postgraduate Diploma in Infectious Diseases</description.thesisname>
<description.thesislevel>Postgraduate diploma</description.thesislevel>
<description.thesisdiscipline>Microbiology</description.thesisdiscipline>
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