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postgraduate thesis: Listeriosis in Hong Kong

TitleListeriosis in Hong Kong
Authors
Issue Date2012
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Lam, K. [林國偉]. (2012). Listeriosis in Hong Kong. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR.
AbstractBackground Listeria monocytogenes is an uncommon but important cause of bacteremia and meningitis in Hong Kong. Our aim is to study the local epidemiology, clinical features, antibiotic susceptibility pattern and outcome of Listeriosis in Hong Kong. Methods A retrospective study was carried out in two local microbiology laboratories in Hong Kong. All patients with positive Listeria monocytogenes isolates in any clinical specimens over the past 10 years were included. Results A total of 31 patients with 41 Listeria monocytogenes isolates were identified in our series. Fever was the most common presentation (80% of patients). There were 20 cases of bacteremia, 3 cases of meningitis and 3 cases of bacteremic meningitis. In non-perinatal cases, most of the patients had underlying medical conditions. The most common associated co-morbidity was underlying malignancy. The mortality of Listeria monocytogenes infection was 24%. The stillbirth rate in pregnant women was 40%. 27% of patients were documented to have consumed dairy products or other high-risk foods. There were 2 isolates intermediate sensitivity to penicillin while all tested isolates were 100% sensitive to ampicillin, Septrin and vancomycin. Mortality was not associated with appropriate antibiotic use, use of immunosuppressants or advanced age. Conclusions Human Listeriosis is a rare but important infection in Hong Kong. It particularly affects newborns, pregnant women and immunocompromised hosts, and carries a high risk of mortality and stillbirth.
DescriptionThesis (P. Dip.)--University of Hong Kong, 2012.
"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
Includes bibliographical references.
DegreePostgraduate Diploma in Infectious Diseases
SubjectListeriosis -- China -- Hong Kong.
Dept/ProgramMicrobiology
Persistent Identifierhttp://hdl.handle.net/10722/173738

 

DC FieldValueLanguage
dc.contributor.authorLam, Kwok-waien_HK
dc.contributor.author林國偉zh_HK
dc.date.accessioned2012-11-01T02:50:32Z-
dc.date.available2012-11-01T02:50:32Z-
dc.date.issued2012en_US
dc.identifier.citationLam, K. [林國偉]. (2012). Listeriosis in Hong Kong. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR.-
dc.identifier.urihttp://hdl.handle.net/10722/173738-
dc.descriptionThesis (P. Dip.)--University of Hong Kong, 2012.en_US
dc.description"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."en_US
dc.descriptionIncludes bibliographical references.en_US
dc.description.abstractBackground Listeria monocytogenes is an uncommon but important cause of bacteremia and meningitis in Hong Kong. Our aim is to study the local epidemiology, clinical features, antibiotic susceptibility pattern and outcome of Listeriosis in Hong Kong. Methods A retrospective study was carried out in two local microbiology laboratories in Hong Kong. All patients with positive Listeria monocytogenes isolates in any clinical specimens over the past 10 years were included. Results A total of 31 patients with 41 Listeria monocytogenes isolates were identified in our series. Fever was the most common presentation (80% of patients). There were 20 cases of bacteremia, 3 cases of meningitis and 3 cases of bacteremic meningitis. In non-perinatal cases, most of the patients had underlying medical conditions. The most common associated co-morbidity was underlying malignancy. The mortality of Listeria monocytogenes infection was 24%. The stillbirth rate in pregnant women was 40%. 27% of patients were documented to have consumed dairy products or other high-risk foods. There were 2 isolates intermediate sensitivity to penicillin while all tested isolates were 100% sensitive to ampicillin, Septrin and vancomycin. Mortality was not associated with appropriate antibiotic use, use of immunosuppressants or advanced age. Conclusions Human Listeriosis is a rare but important infection in Hong Kong. It particularly affects newborns, pregnant women and immunocompromised hosts, and carries a high risk of mortality and stillbirth.en_US
dc.languageengen_US
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.en_US
dc.subject.lcshListeriosis -- China -- Hong Kong.en_US
dc.titleListeriosis in Hong Kongen_HK
dc.typePG_Thesisen_US
dc.identifier.hkulb4832052en_US
dc.description.thesisnamePostgraduate Diploma in Infectious Diseasesen_US
dc.description.thesislevelPostgraduate diplomaen_US
dc.description.thesisdisciplineMicrobiologyen_US
dc.description.naturepublished_or_final_versionen_US

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