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Undergraduate Thesis: Distortion product otoacoustic emissions in patients with haemophilia
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TitleDistortion product otoacoustic emissions in patients with haemophilia
 
AuthorsLeung, Hei-tin
梁曦田
 
Issue Date2010
 
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
AbstractThis study investigated the cochlear function of 13 haemophilic patients using distortion product otoacoustic emission (DPOAE) assessment techniques. Out of the 26 ears examined, a minority of them produced responses that were considered to be impaired. A positive correlation was found between clotting factor level and DPOAE amplitude, and DPOAE/ noise ratio at high frequencies (4, 6, 8 kHz). Clotting factor level, which is indicative of the severity of haemophilia, may be related to hearing status. It was also revealed that DPOAE amplitude and DPOAE/ noise ratio at low frequencies (1, 2, 3 kHz) were greater than those at high frequencies (4, 6, 8 kHz). Therefore the high-frequency cochlear region may be more sensitive to damage. Intracranial micro-haemorrhage in haemophilic individuals may be linked to an increased risk of cochlear damage. Further studies may use brain computed tomography scan to explore the possible link between intracranial micro-haemorrhage and hearing loss.
 
Description"A dissertation submitted in partial fulfillment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2010."
Includes bibliographical references (p. 22-24).
Thesis (B.Sc)--University of Hong Kong, 2010.
 
DegreeBachelor of Science in Speech and Hearing Sciences
 
SubjectOtoacoustic emissions.
Hemophiliacs.
 
Dept/ProgramSpeech and Hearing Sciences
 
DC FieldValue
dc.contributor.authorLeung, Hei-tin
 
dc.contributor.author梁曦田
 
dc.date.accessioned2012-11-01T01:14:08Z
 
dc.date.available2012-11-01T01:14:08Z
 
dc.date.issued2010
 
dc.description.abstractThis study investigated the cochlear function of 13 haemophilic patients using distortion product otoacoustic emission (DPOAE) assessment techniques. Out of the 26 ears examined, a minority of them produced responses that were considered to be impaired. A positive correlation was found between clotting factor level and DPOAE amplitude, and DPOAE/ noise ratio at high frequencies (4, 6, 8 kHz). Clotting factor level, which is indicative of the severity of haemophilia, may be related to hearing status. It was also revealed that DPOAE amplitude and DPOAE/ noise ratio at low frequencies (1, 2, 3 kHz) were greater than those at high frequencies (4, 6, 8 kHz). Therefore the high-frequency cochlear region may be more sensitive to damage. Intracranial micro-haemorrhage in haemophilic individuals may be linked to an increased risk of cochlear damage. Further studies may use brain computed tomography scan to explore the possible link between intracranial micro-haemorrhage and hearing loss.
 
dc.description.naturepublished_or_final_version
 
dc.description"A dissertation submitted in partial fulfillment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2010."
 
dc.descriptionIncludes bibliographical references (p. 22-24).
 
dc.descriptionThesis (B.Sc)--University of Hong Kong, 2010.
 
dc.description.thesisdisciplineSpeech and Hearing Sciences
 
dc.description.thesislevelBachelor's
 
dc.description.thesisnameBachelor of Science in Speech and Hearing Sciences
 
dc.identifier.hkulb4813170
 
dc.identifier.urihttp://hdl.handle.net/10722/173719
 
dc.languageeng
 
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.
 
dc.subject.lcshOtoacoustic emissions.
 
dc.subject.lcshHemophiliacs.
 
dc.titleDistortion product otoacoustic emissions in patients with haemophilia
 
dc.typeUG_Thesis
 
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<date.accessioned>2012-11-01T01:14:08Z</date.accessioned>
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<date.issued>2010</date.issued>
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<description>&quot;A dissertation submitted in partial fulfillment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2010.&quot;</description>
<description>Includes bibliographical references (p. 22-24).</description>
<description>Thesis (B.Sc)--University of Hong Kong, 2010.</description>
<description.abstract>This study investigated the cochlear function of 13 haemophilic patients using distortion product
otoacoustic emission (DPOAE) assessment techniques. Out of the 26 ears examined, a minority
of them produced responses that were considered to be impaired. A positive correlation was
found between clotting factor level and DPOAE amplitude, and DPOAE/ noise ratio at high
frequencies (4, 6, 8 kHz). Clotting factor level, which is indicative of the severity of
haemophilia, may be related to hearing status. It was also revealed that DPOAE amplitude and
DPOAE/ noise ratio at low frequencies (1, 2, 3 kHz) were greater than those at high frequencies
(4, 6, 8 kHz). Therefore the high-frequency cochlear region may be more sensitive to damage.
Intracranial micro-haemorrhage in haemophilic individuals may be linked to an increased risk of
cochlear damage. Further studies may use brain computed tomography scan to explore the
possible link between intracranial micro-haemorrhage and hearing loss.</description.abstract>
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<publisher>The University of Hong Kong (Pokfulam, Hong Kong)</publisher>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<rights>The author retains all proprietary rights, (such as patent rights) and the right to use in future works.</rights>
<subject.lcsh>Otoacoustic emissions.</subject.lcsh>
<subject.lcsh>Hemophiliacs.</subject.lcsh>
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