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Conference Paper: Endothelial dysfunction in hypertension

TitleEndothelial dysfunction in hypertension
Authors
Issue Date1996
Citation
Journal Of Hypertension, Supplement, 1996, v. 14 n. 5, p. S83-S93 How to Cite?
AbstractPurpose. To summarize how abnormal release of relaxing and contracting factors from endothelial cells contribute to the vascular abnormalities in hypertension. Endothelium-derived factors. The endothelium controls the tone of the underlying vascular smooth muscle by releasing relaxing and contracting factors. The former include prostacyclin, nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF), and the latter endoperoxides, thromboxane A2, superoxide anions and endothelin. Hypertension In most types of hypertension, endothelium-dependent relaxations are curtailed, because of a reduced production and/or action of endothelium-derived NO and EDHF. In essential hypertension, endothelium-dependent relaxations are reduced also because of the endothelium-dependent production of vasoconstrictor prostanoids (endoperoxides and, in some cases, thromboxane A2). Cause or consequence. The endothelial dysfunction observed in hypertensive blood vessels is likely to be a consequence rather than a cause of the disease process. Therapeutic implications. Enhanced release of endothelium-derived relaxing factors (NO and EDHF) help to explain the therapeutic effects of inhibitors of converting enzyme.
Persistent Identifierhttp://hdl.handle.net/10722/173528
ISSN
2011 SCImago Journal Rankings: 0.600
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:31Z-
dc.date.available2012-10-30T06:32:31Z-
dc.date.issued1996en_US
dc.identifier.citationJournal Of Hypertension, Supplement, 1996, v. 14 n. 5, p. S83-S93en_US
dc.identifier.issn0952-1178en_US
dc.identifier.urihttp://hdl.handle.net/10722/173528-
dc.description.abstractPurpose. To summarize how abnormal release of relaxing and contracting factors from endothelial cells contribute to the vascular abnormalities in hypertension. Endothelium-derived factors. The endothelium controls the tone of the underlying vascular smooth muscle by releasing relaxing and contracting factors. The former include prostacyclin, nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF), and the latter endoperoxides, thromboxane A2, superoxide anions and endothelin. Hypertension In most types of hypertension, endothelium-dependent relaxations are curtailed, because of a reduced production and/or action of endothelium-derived NO and EDHF. In essential hypertension, endothelium-dependent relaxations are reduced also because of the endothelium-dependent production of vasoconstrictor prostanoids (endoperoxides and, in some cases, thromboxane A2). Cause or consequence. The endothelial dysfunction observed in hypertensive blood vessels is likely to be a consequence rather than a cause of the disease process. Therapeutic implications. Enhanced release of endothelium-derived relaxing factors (NO and EDHF) help to explain the therapeutic effects of inhibitors of converting enzyme.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Hypertension, Supplementen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Drug Therapy - Physiopathologyen_US
dc.subject.meshVasoconstriction - Physiologyen_US
dc.subject.meshVasodilation - Physiologyen_US
dc.titleEndothelial dysfunction in hypertensionen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9120689-
dc.identifier.scopuseid_2-s2.0-0030469192en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030469192&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue5en_US
dc.identifier.spageS83en_US
dc.identifier.epageS93en_US
dc.identifier.isiWOS:A1996WE73800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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