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Conference Paper: Endothelins and membrane potential of vascular smooth muscle of the canine coronary artery

TitleEndothelins and membrane potential of vascular smooth muscle of the canine coronary artery
Authors
Issue Date1993
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S229-S231 How to Cite?
AbstractWe investigated the effects of endothelins on the membrane potential of vascular smooth-muscle cells of canine coronary artery, using glass microelectrodes. In tissues with endothelium, endothelin-1 (ET-1), from 10- 12 to 10-9 M, did not alter the membrane potential. Higher concentrations of the peptide produced sustained depolarization without detectable hyperpolarization. Endothelin-3 (ET-3, 10-11 to 10-8 M) did not produce significant membrane hyperpolarization in tissues with endothelium. Prostaglandin F(2α) (10-5 M) depolarized the cell membrane by about 6 mV. ET-1 (10-9 M) did not evoke detectable hyperpolarization in the presence of prostaglandin F(2α). In tissues incubated with BQ123 (10-6 M, a selective ET(A)-receptor antagonist), which attenuated the depolarization evoked by ET- 1, both isopeptides did not produce detectable hyperpolarization. These findings suggest that ET-1 and ET-3 do not evoke the release of endothelium- derived hyperpolarizing factor in the canine coronary artery.
Persistent Identifierhttp://hdl.handle.net/10722/173519
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNakashima, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:28Z-
dc.date.available2012-10-30T06:32:28Z-
dc.date.issued1993en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S229-S231en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173519-
dc.description.abstractWe investigated the effects of endothelins on the membrane potential of vascular smooth-muscle cells of canine coronary artery, using glass microelectrodes. In tissues with endothelium, endothelin-1 (ET-1), from 10- 12 to 10-9 M, did not alter the membrane potential. Higher concentrations of the peptide produced sustained depolarization without detectable hyperpolarization. Endothelin-3 (ET-3, 10-11 to 10-8 M) did not produce significant membrane hyperpolarization in tissues with endothelium. Prostaglandin F(2α) (10-5 M) depolarized the cell membrane by about 6 mV. ET-1 (10-9 M) did not evoke detectable hyperpolarization in the presence of prostaglandin F(2α). In tissues incubated with BQ123 (10-6 M, a selective ET(A)-receptor antagonist), which attenuated the depolarization evoked by ET- 1, both isopeptides did not produce detectable hyperpolarization. These findings suggest that ET-1 and ET-3 do not evoke the release of endothelium- derived hyperpolarizing factor in the canine coronary artery.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelins - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Potentials - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshPeptides, Cyclic - Pharmacologyen_US
dc.subject.meshReceptors, Endothelin - Antagonists & Inhibitorsen_US
dc.titleEndothelins and membrane potential of vascular smooth muscle of the canine coronary arteryen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-199322008-00061-
dc.identifier.pmid7509952-
dc.identifier.scopuseid_2-s2.0-0027764530en_US
dc.identifier.volume22en_US
dc.identifier.issueSUPPL. 8en_US
dc.identifier.spageS229en_US
dc.identifier.epageS231en_US
dc.identifier.isiWOS:A1993MN02800061-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNakashima, M=35599797500en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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