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Conference Paper: Local production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteries

TitleLocal production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteries
Authors
Issue Date1992
Citation
Agents And Actions, 1992, v. 38 SUPPL. III, p. 186-195 How to Cite?
AbstractThe angiotensin converting enzyme (ACE) inhibitor perindoprilat evokes endothelium-dependent relaxations in perfused isolated canine arteries. Kininogens, the precursors of bradykinin, elicit endothelium-dependent relaxations which are potentiated by perindoprilat, inhibited by B2-kinin antagonists and partially impaired after inhibition of NO synthase. These observations suggest that locally produced kinins may stimulate the production of NO and endothelium-derived hyperpolarizing factor, and that this action is potentiated by ACE inhibitors.
Persistent Identifierhttp://hdl.handle.net/10722/173506
ISSN

 

DC FieldValueLanguage
dc.contributor.authorMombouli, JVen_US
dc.contributor.authorIlliano, Sen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:24Z-
dc.date.available2012-10-30T06:32:24Z-
dc.date.issued1992en_US
dc.identifier.citationAgents And Actions, 1992, v. 38 SUPPL. III, p. 186-195en_US
dc.identifier.issn0065-4299en_US
dc.identifier.urihttp://hdl.handle.net/10722/173506-
dc.description.abstractThe angiotensin converting enzyme (ACE) inhibitor perindoprilat evokes endothelium-dependent relaxations in perfused isolated canine arteries. Kininogens, the precursors of bradykinin, elicit endothelium-dependent relaxations which are potentiated by perindoprilat, inhibited by B2-kinin antagonists and partially impaired after inhibition of NO synthase. These observations suggest that locally produced kinins may stimulate the production of NO and endothelium-derived hyperpolarizing factor, and that this action is potentiated by ACE inhibitors.en_US
dc.languageengen_US
dc.relation.ispartofAgents and Actionsen_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshBradykinin - Analogs & Derivatives - Antagonists & Inhibitors - Pharmacologyen_US
dc.subject.meshCarotid Arteries - Drug Effects - Metabolism - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshIndoles - Pharmacologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshKininogens - Pharmacologyen_US
dc.subject.meshKinins - Metabolismen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Metabolism - Physiologyen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshVasodilation - Drug Effects - Physiologyen_US
dc.titleLocal production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteriesen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1462858-
dc.identifier.scopuseid_2-s2.0-0026787962en_US
dc.identifier.volume38en_US
dc.identifier.issueSUPPL. IIIen_US
dc.identifier.spage186en_US
dc.identifier.epage195en_US
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridMombouli, JV=7004285772en_US
dc.identifier.scopusauthoridIlliano, S=6602119848en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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