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Conference Paper: Local production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteries
Title | Local production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteries |
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Authors | |
Issue Date | 1992 |
Citation | Agents And Actions, 1992, v. 38 SUPPL. III, p. 186-195 How to Cite? |
Abstract | The angiotensin converting enzyme (ACE) inhibitor perindoprilat evokes endothelium-dependent relaxations in perfused isolated canine arteries. Kininogens, the precursors of bradykinin, elicit endothelium-dependent relaxations which are potentiated by perindoprilat, inhibited by B2-kinin antagonists and partially impaired after inhibition of NO synthase. These observations suggest that locally produced kinins may stimulate the production of NO and endothelium-derived hyperpolarizing factor, and that this action is potentiated by ACE inhibitors. |
Persistent Identifier | http://hdl.handle.net/10722/173506 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Mombouli, JV | en_US |
dc.contributor.author | Illiano, S | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:32:24Z | - |
dc.date.available | 2012-10-30T06:32:24Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Agents And Actions, 1992, v. 38 SUPPL. III, p. 186-195 | en_US |
dc.identifier.issn | 0065-4299 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173506 | - |
dc.description.abstract | The angiotensin converting enzyme (ACE) inhibitor perindoprilat evokes endothelium-dependent relaxations in perfused isolated canine arteries. Kininogens, the precursors of bradykinin, elicit endothelium-dependent relaxations which are potentiated by perindoprilat, inhibited by B2-kinin antagonists and partially impaired after inhibition of NO synthase. These observations suggest that locally produced kinins may stimulate the production of NO and endothelium-derived hyperpolarizing factor, and that this action is potentiated by ACE inhibitors. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Agents and Actions | en_US |
dc.subject.mesh | Angiotensin-Converting Enzyme Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arginine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Bradykinin - Analogs & Derivatives - Antagonists & Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Carotid Arteries - Drug Effects - Metabolism - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology | en_US |
dc.subject.mesh | Indoles - Pharmacology | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Kininogens - Pharmacology | en_US |
dc.subject.mesh | Kinins - Metabolism | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Metabolism - Physiology | en_US |
dc.subject.mesh | Nitroarginine | en_US |
dc.subject.mesh | Nitroprusside - Pharmacology | en_US |
dc.subject.mesh | Vasodilation - Drug Effects - Physiology | en_US |
dc.title | Local production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteries | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 1462858 | - |
dc.identifier.scopus | eid_2-s2.0-0026787962 | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | SUPPL. III | en_US |
dc.identifier.spage | 186 | en_US |
dc.identifier.epage | 195 | en_US |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Mombouli, JV=7004285772 | en_US |
dc.identifier.scopusauthorid | Illiano, S=6602119848 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0065-4299 | - |