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Conference Paper: Intrarenal mechanisms that regulate sodium excretion in relationship to changes in blood pressure

TitleIntrarenal mechanisms that regulate sodium excretion in relationship to changes in blood pressure
Authors
Issue Date1989
PublisherDowden Health Media, Inc. The Journal's web site is located at http://www.mayoclinicproceedings.com
Citation
Mayo Clinic Proceedings, 1989, v. 64 n. 11, p. 1406-1424 How to Cite?
AbstractBecause pressure-related natriuresis may be central to the regulatory role of the kidney on blood pressure, it is important to understand the relationship of humoral systems involved in the control of renal hemodyanmics and tubular function. The preglomerular endothelial synthesis of prostaglandin I2 and endothelium-derived relaxing factor seem to modulate autoregulatory control by the afferent arterioles and the release of renin by the juxtaglomerular apparatus. The release of renin is followed by an increase in angiotensin II in the renal interstitium, which is responsible for adjusting the vascular tone of the efferent arterioles and vasa recta and for stimulating proximal tubular reabsorption of sodium. Variations in medullary production of prostaglandins E2 and I2 and, ultimately, could modulate sodium reabsorption in the medullary thick ascending limbs and the collecting ducts.
Persistent Identifierhttp://hdl.handle.net/10722/173461
ISSN
2015 Impact Factor: 5.92
2015 SCImago Journal Rankings: 2.456
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRomero, JCen_US
dc.contributor.authorBentley, MDen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorKnox, FGen_US
dc.date.accessioned2012-10-30T06:32:11Z-
dc.date.available2012-10-30T06:32:11Z-
dc.date.issued1989en_US
dc.identifier.citationMayo Clinic Proceedings, 1989, v. 64 n. 11, p. 1406-1424en_US
dc.identifier.issn0025-6196en_US
dc.identifier.urihttp://hdl.handle.net/10722/173461-
dc.description.abstractBecause pressure-related natriuresis may be central to the regulatory role of the kidney on blood pressure, it is important to understand the relationship of humoral systems involved in the control of renal hemodyanmics and tubular function. The preglomerular endothelial synthesis of prostaglandin I2 and endothelium-derived relaxing factor seem to modulate autoregulatory control by the afferent arterioles and the release of renin by the juxtaglomerular apparatus. The release of renin is followed by an increase in angiotensin II in the renal interstitium, which is responsible for adjusting the vascular tone of the efferent arterioles and vasa recta and for stimulating proximal tubular reabsorption of sodium. Variations in medullary production of prostaglandins E2 and I2 and, ultimately, could modulate sodium reabsorption in the medullary thick ascending limbs and the collecting ducts.en_US
dc.languageengen_US
dc.publisherDowden Health Media, Inc. The Journal's web site is located at http://www.mayoclinicproceedings.comen_US
dc.relation.ispartofMayo Clinic Proceedingsen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshEpoprostenol - Biosynthesisen_US
dc.subject.meshHomeostasisen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Etiologyen_US
dc.subject.meshKidney - Physiologyen_US
dc.subject.meshNatriuresis - Physiologyen_US
dc.subject.meshNitric Oxide - Secretionen_US
dc.subject.meshSodium, Dietary - Metabolismen_US
dc.titleIntrarenal mechanisms that regulate sodium excretion in relationship to changes in blood pressureen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0025-6196(12)65383-X-
dc.identifier.pmid2512459-
dc.identifier.scopuseid_2-s2.0-0024815009en_US
dc.identifier.volume64en_US
dc.identifier.issue11en_US
dc.identifier.spage1406en_US
dc.identifier.epage1424en_US
dc.identifier.isiWOS:A1989CF37100008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRomero, JC=7402018868en_US
dc.identifier.scopusauthoridBentley, MD=7101787937en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridKnox, FG=7102239703en_US

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