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Conference Paper: Rhythmic release pattern of pineal melatonin in rodents

TitleRhythmic release pattern of pineal melatonin in rodents
Authors
Issue Date1991
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEN
Citation
Neuroendocrinology, 1991, v. 53 SUPPL. 1, p. 60-67 How to Cite?
AbstractThe plasma melatonin in the confluens sinuum of anesthetized rabbits and rats exhibited an episodic release pattern, with pulses superimposed on a basal level. The rhythmicity of pineal melatonin release revealed by our experimental paradigm was dependent on the blood sampling interval. In rabbits, it was found that the plasma melatonin level in the confluens sinuum was 7-15 times higher than that obtained from the plasma collected at the same time from the peripheral artery where the melatonin level also showed a pulsatile pattern. Diurnal variation in pineal melatonin level in the confluens sinuum was observed only in acutely blinded rabbits and rats. Electrical stimulation of the unilateral cervical sympathetic trunk of rabbits resulted in elevation of the level of plasma melatonin in the confluens sinuum, while the frequency of pulse peaks of plasma melatonin revealed at 4-min intervals was not affected. Similar results were obtained in rabbits with systemic administration of beta-adrenergic agents. These findings suggest that the release of pineal melatonin into the confluens sinuum is under the regulation of the cervical sympathetic system. The sympathetic influence on pineal melatonin secretion seems to vary with age. Furthermore, age-related fluctuation of systemic blood melatonin appeared to be the results of changes in the rate of pineal melatonin secretion, body growth and ageing.
Persistent Identifierhttp://hdl.handle.net/10722/173430
ISSN
2015 Impact Factor: 2.583
2015 SCImago Journal Rankings: 1.479
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, YSen_US
dc.contributor.authorCheung, YMen_US
dc.contributor.authorPang, SFen_US
dc.date.accessioned2012-10-30T06:31:22Z-
dc.date.available2012-10-30T06:31:22Z-
dc.date.issued1991en_US
dc.identifier.citationNeuroendocrinology, 1991, v. 53 SUPPL. 1, p. 60-67en_US
dc.identifier.issn0028-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/173430-
dc.description.abstractThe plasma melatonin in the confluens sinuum of anesthetized rabbits and rats exhibited an episodic release pattern, with pulses superimposed on a basal level. The rhythmicity of pineal melatonin release revealed by our experimental paradigm was dependent on the blood sampling interval. In rabbits, it was found that the plasma melatonin level in the confluens sinuum was 7-15 times higher than that obtained from the plasma collected at the same time from the peripheral artery where the melatonin level also showed a pulsatile pattern. Diurnal variation in pineal melatonin level in the confluens sinuum was observed only in acutely blinded rabbits and rats. Electrical stimulation of the unilateral cervical sympathetic trunk of rabbits resulted in elevation of the level of plasma melatonin in the confluens sinuum, while the frequency of pulse peaks of plasma melatonin revealed at 4-min intervals was not affected. Similar results were obtained in rabbits with systemic administration of beta-adrenergic agents. These findings suggest that the release of pineal melatonin into the confluens sinuum is under the regulation of the cervical sympathetic system. The sympathetic influence on pineal melatonin secretion seems to vary with age. Furthermore, age-related fluctuation of systemic blood melatonin appeared to be the results of changes in the rate of pineal melatonin secretion, body growth and ageing.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NENen_US
dc.relation.ispartofNeuroendocrinologyen_US
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshMelatonin - Blood - Secretionen_US
dc.subject.meshPeriodicityen_US
dc.subject.meshPineal Gland - Secretionen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.subject.meshSympathetic Nervous System - Physiologyen_US
dc.titleRhythmic release pattern of pineal melatonin in rodentsen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000125797-
dc.identifier.pmid1901392-
dc.identifier.scopuseid_2-s2.0-0025961479en_US
dc.identifier.volume53en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spage60en_US
dc.identifier.epage67en_US
dc.identifier.isiWOS:A1991EY58700011-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US
dc.identifier.scopusauthoridCheung, YM=24521372000en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US

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