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Article: An update on gestational trophoblastic disease

TitleAn update on gestational trophoblastic disease
Authors
KeywordsChoriocarcinoma
Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasia
Management
Mole
Issue Date2012
Citation
Obstetrics, Gynaecology And Reproductive Medicine, 2012, v. 22 n. 1, p. 7-14 How to Cite?
AbstractGestational trophoblastic disease is a rare pregnancy-related disorder. It comprises of partial mole, complete mole, invasive and metastatic mole, choriocarcinoma, placental site trophoblastic tumour and epithelioid trophoblastic tumour. Novel immunohistochemical technologies have helped in the diagnosis of the disease and some of the genes may also serve as prognostic markers. Partial and complete moles can be treated by suction evacuation and most patients do not require further treatment. However, 10-20% of them may develop gestational trophoblastic neoplasia. The Gynecological Oncology Committee has adopted a staging system with incorporation of the modified World Health Organization scoring system. Low-risk disease is treated by single-agent chemotherapy while high-risk disease is treated by multi-agent chemotherapy. The overall cure rate is more than 90% and most patients can preserve fertility and anticipate normal pregnancy outcomes. Nevertheless, the disease can recur. Referral to a specialist centre is important to ensure proper monitoring and management. © 2011.
Persistent Identifierhttp://hdl.handle.net/10722/173370
ISSN
2015 SCImago Journal Rankings: 0.158
References

 

DC FieldValueLanguage
dc.contributor.authorTse, KYen_US
dc.contributor.authorChan, KKLen_US
dc.contributor.authorTam, KFen_US
dc.contributor.authorNgan, HYSen_US
dc.date.accessioned2012-10-30T06:29:40Z-
dc.date.available2012-10-30T06:29:40Z-
dc.date.issued2012en_US
dc.identifier.citationObstetrics, Gynaecology And Reproductive Medicine, 2012, v. 22 n. 1, p. 7-14en_US
dc.identifier.issn1751-7214en_US
dc.identifier.urihttp://hdl.handle.net/10722/173370-
dc.description.abstractGestational trophoblastic disease is a rare pregnancy-related disorder. It comprises of partial mole, complete mole, invasive and metastatic mole, choriocarcinoma, placental site trophoblastic tumour and epithelioid trophoblastic tumour. Novel immunohistochemical technologies have helped in the diagnosis of the disease and some of the genes may also serve as prognostic markers. Partial and complete moles can be treated by suction evacuation and most patients do not require further treatment. However, 10-20% of them may develop gestational trophoblastic neoplasia. The Gynecological Oncology Committee has adopted a staging system with incorporation of the modified World Health Organization scoring system. Low-risk disease is treated by single-agent chemotherapy while high-risk disease is treated by multi-agent chemotherapy. The overall cure rate is more than 90% and most patients can preserve fertility and anticipate normal pregnancy outcomes. Nevertheless, the disease can recur. Referral to a specialist centre is important to ensure proper monitoring and management. © 2011.en_US
dc.languageengen_US
dc.relation.ispartofObstetrics, Gynaecology and Reproductive Medicineen_US
dc.subjectChoriocarcinomaen_US
dc.subjectGestational Trophoblastic Diseaseen_US
dc.subjectGestational Trophoblastic Neoplasiaen_US
dc.subjectManagementen_US
dc.subjectMoleen_US
dc.titleAn update on gestational trophoblastic diseaseen_US
dc.typeArticleen_US
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityChan, KKL=rp00499en_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ogrm.2011.10.004en_US
dc.identifier.scopuseid_2-s2.0-84855862384en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855862384&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue1en_US
dc.identifier.spage7en_US
dc.identifier.epage14en_US
dc.identifier.scopusauthoridTse, KY=8876026900en_US
dc.identifier.scopusauthoridChan, KKL=8655666700en_US
dc.identifier.scopusauthoridTam, KF=7201692816en_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US

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