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Article: HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine

TitleHPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine
Authors
Issue Date2008
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2008, v. 26 n. 52, p. 6844-6851 How to Cite?
AbstractThe efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day 1 and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/173340
ISSN
2015 Impact Factor: 3.413
2015 SCImago Journal Rankings: 2.044
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJoura, EAen_US
dc.contributor.authorKjaer, SKen_US
dc.contributor.authorWheeler, CMen_US
dc.contributor.authorSigurdsson, Ken_US
dc.contributor.authorIversen, OEen_US
dc.contributor.authorHernandezAvila, Men_US
dc.contributor.authorPerez, Gen_US
dc.contributor.authorBrown, DRen_US
dc.contributor.authorKoutsky, LAen_US
dc.contributor.authorTay, EHen_US
dc.contributor.authorGarcía, Pen_US
dc.contributor.authorAult, KAen_US
dc.contributor.authorGarland, SMen_US
dc.contributor.authorLeodolter, Sen_US
dc.contributor.authorOlsson, SEen_US
dc.contributor.authorTang, GWKen_US
dc.contributor.authorFerris, DGen_US
dc.contributor.authorPaavonen, Jen_US
dc.contributor.authorLehtinen, Men_US
dc.contributor.authorSteben, Men_US
dc.contributor.authorBosch, Xen_US
dc.contributor.authorDillner, Jen_US
dc.contributor.authorKurman, RJen_US
dc.contributor.authorMajewski, Sen_US
dc.contributor.authorMuñoz, Nen_US
dc.contributor.authorMyers, ERen_US
dc.contributor.authorVilla, LLen_US
dc.contributor.authorTaddeo, FJen_US
dc.contributor.authorRoberts, Cen_US
dc.contributor.authorTadesse, Aen_US
dc.contributor.authorBryan, Jen_US
dc.contributor.authorLupinacci, LCen_US
dc.contributor.authorGiacoletti, KEDen_US
dc.contributor.authorLu, Sen_US
dc.contributor.authorVuocolo, Sen_US
dc.contributor.authorHesley, TMen_US
dc.contributor.authorHaupt, RMen_US
dc.contributor.authorBarr, Een_US
dc.date.accessioned2012-10-30T06:29:29Z-
dc.date.available2012-10-30T06:29:29Z-
dc.date.issued2008en_US
dc.identifier.citationVaccine, 2008, v. 26 n. 52, p. 6844-6851en_US
dc.identifier.issn0264-410Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173340-
dc.description.abstractThe efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day 1 and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers. © 2008 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_US
dc.relation.ispartofVaccineen_US
dc.rightsVaccine. Copyright © Elsevier Ltd.-
dc.subject.meshAdolescenten_US
dc.subject.meshAntibodies, Viral - Analysis - Biosynthesis - Immunologyen_US
dc.subject.meshCondylomata Acuminata - Epidemiology - Immunology - Prevention & Controlen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHuman Papillomavirus 11 - Immunologyen_US
dc.subject.meshHuman Papillomavirus 16 - Immunologyen_US
dc.subject.meshHuman Papillomavirus 18 - Immunologyen_US
dc.subject.meshHuman Papillomavirus 6 - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization Scheduleen_US
dc.subject.meshPapillomavirus Infections - Immunology - Pathology - Prevention & Controlen_US
dc.subject.meshPapillomavirus Vaccines - Immunologyen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshVagina - Pathologyen_US
dc.subject.meshVaginal Smearsen_US
dc.subject.meshVulva - Pathologyen_US
dc.subject.meshYoung Adulten_US
dc.titleHPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccineen_US
dc.typeArticleen_US
dc.identifier.emailTang, GWK:gwktang@hkucc.hku.hken_US
dc.identifier.authorityTang, GWK=rp00328en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.vaccine.2008.09.073en_US
dc.identifier.pmid18930097-
dc.identifier.scopuseid_2-s2.0-56949087305en_US
dc.identifier.hkuros166995-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56949087305&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue52en_US
dc.identifier.spage6844en_US
dc.identifier.epage6851en_US
dc.identifier.isiWOS:000261898400019-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridJoura, EA=7004817276en_US
dc.identifier.scopusauthoridKjaer, SK=7004418213en_US
dc.identifier.scopusauthoridWheeler, CM=7202505711en_US
dc.identifier.scopusauthoridSigurdsson, K=35475355400en_US
dc.identifier.scopusauthoridIversen, OE=7102966661en_US
dc.identifier.scopusauthoridHernandezAvila, M=7005968193en_US
dc.identifier.scopusauthoridPerez, G=16307983600en_US
dc.identifier.scopusauthoridBrown, DR=7407095050en_US
dc.identifier.scopusauthoridKoutsky, LA=7006120337en_US
dc.identifier.scopusauthoridTay, EH=7004902850en_US
dc.identifier.scopusauthoridGarcía, P=7201693727en_US
dc.identifier.scopusauthoridAult, KA=7005241226en_US
dc.identifier.scopusauthoridGarland, SM=7102220459en_US
dc.identifier.scopusauthoridLeodolter, S=7005056838en_US
dc.identifier.scopusauthoridOlsson, SE=7202623557en_US
dc.identifier.scopusauthoridTang, GWK=7401633864en_US
dc.identifier.scopusauthoridFerris, DG=17634377600en_US
dc.identifier.scopusauthoridPaavonen, J=7102724434en_US
dc.identifier.scopusauthoridLehtinen, M=35479268300en_US
dc.identifier.scopusauthoridSteben, M=6602790643en_US
dc.identifier.scopusauthoridBosch, X=23990295900en_US
dc.identifier.scopusauthoridDillner, J=7007135194en_US
dc.identifier.scopusauthoridKurman, RJ=7101640655en_US
dc.identifier.scopusauthoridMajewski, S=7103224726en_US
dc.identifier.scopusauthoridMuñoz, N=7102360543en_US
dc.identifier.scopusauthoridMyers, ER=35433205900en_US
dc.identifier.scopusauthoridVilla, LL=7102824355en_US
dc.identifier.scopusauthoridTaddeo, FJ=6603004214en_US
dc.identifier.scopusauthoridRoberts, C=35474924800en_US
dc.identifier.scopusauthoridTadesse, A=6602812727en_US
dc.identifier.scopusauthoridBryan, J=7202481712en_US
dc.identifier.scopusauthoridLupinacci, LC=16307166200en_US
dc.identifier.scopusauthoridGiacoletti, KED=15131768700en_US
dc.identifier.scopusauthoridLu, S=54899768500en_US
dc.identifier.scopusauthoridVuocolo, S=16403558200en_US
dc.identifier.scopusauthoridHesley, TM=6603486789en_US
dc.identifier.scopusauthoridHaupt, RM=11940557600en_US
dc.identifier.scopusauthoridBarr, E=7005643832en_US
dc.identifier.citeulike3445864-

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