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Article: Human chorionic gonadotropin and plasma protein-A in alpha 0-thalassemia pregnancies

TitleHuman chorionic gonadotropin and plasma protein-A in alpha 0-thalassemia pregnancies
Authors
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.org
Citation
Obstetrics And Gynecology, 2006, v. 108 n. 3 I, p. 651-655 How to Cite?
AbstractOBJECTIVE: Maternal serum free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) have been used effectively in the screening of Down syndrome in the first trimester. In this study, we aim to measure the value of first-trimester maternal serum free β-hCG and PAPP-A as predictors of homozygous α-thalassemia-affected pregnancies. METHODS: Free β-hCG and PAPP-A concentrations were measured in stored maternal serum samples obtained at 12 weeks of gestation from 22 women with fetuses affected by homozygous α-thalassemia and from 436 controls matched for maternal age, ethnicity, and weight, as well as gestation at blood sampling. RESULTS: Maternal serum concentration of free β-hCG was significantly increased in women with pregnancies affected by homozygous α-thalassemia than in controls (P=.001). Concentrations of PAPP-A did not differ between the cases affected by homozygous α-thalassemia and the controls (P=.652). CONCLUSION: Pregnancies affected by homozygous α-thalassemia are associated with increased maternal serum free β-hCG at 11-14 weeks of gestation. This serum analyte alone may not be clinically useful as a predictor of pregnancies affected by homozygous α-thalassemia. However, the absence of ultrasound features of fetal anemia and hydropic changes, together with normal maternal serum free β-hCG and PAPP-A in the first trimester, will be reassuring signs of normality for fetuses at risk of homozygous α-thalassemia and, hence, enable women to avoid invasive tests in unaffected pregnancies. © 2006 by The American College of Obstetricians and Gynecologists. Published by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/173310
ISSN
2015 Impact Factor: 5.656
2015 SCImago Journal Rankings: 2.899
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorLeung, KYen_HK
dc.contributor.authorLau, Een_HK
dc.contributor.authorTang, MHYen_HK
dc.date.accessioned2012-10-30T06:29:13Z-
dc.date.available2012-10-30T06:29:13Z-
dc.date.issued2006en_HK
dc.identifier.citationObstetrics And Gynecology, 2006, v. 108 n. 3 I, p. 651-655en_HK
dc.identifier.issn0029-7844en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173310-
dc.description.abstractOBJECTIVE: Maternal serum free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) have been used effectively in the screening of Down syndrome in the first trimester. In this study, we aim to measure the value of first-trimester maternal serum free β-hCG and PAPP-A as predictors of homozygous α-thalassemia-affected pregnancies. METHODS: Free β-hCG and PAPP-A concentrations were measured in stored maternal serum samples obtained at 12 weeks of gestation from 22 women with fetuses affected by homozygous α-thalassemia and from 436 controls matched for maternal age, ethnicity, and weight, as well as gestation at blood sampling. RESULTS: Maternal serum concentration of free β-hCG was significantly increased in women with pregnancies affected by homozygous α-thalassemia than in controls (P=.001). Concentrations of PAPP-A did not differ between the cases affected by homozygous α-thalassemia and the controls (P=.652). CONCLUSION: Pregnancies affected by homozygous α-thalassemia are associated with increased maternal serum free β-hCG at 11-14 weeks of gestation. This serum analyte alone may not be clinically useful as a predictor of pregnancies affected by homozygous α-thalassemia. However, the absence of ultrasound features of fetal anemia and hydropic changes, together with normal maternal serum free β-hCG and PAPP-A in the first trimester, will be reassuring signs of normality for fetuses at risk of homozygous α-thalassemia and, hence, enable women to avoid invasive tests in unaffected pregnancies. © 2006 by The American College of Obstetricians and Gynecologists. Published by Lippincott Williams & Wilkins.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.orgen_HK
dc.relation.ispartofObstetrics and Gynecologyen_HK
dc.rightsObstetrics and Gynecology. Copyright © Lippincott Williams & Wilkins.-
dc.subject.meshAdulten_US
dc.subject.meshBiological Markers - Analysis - Blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Analysis - Blooden_US
dc.subject.meshFalse Positive Reactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Blood - Diagnosis - Geneticsen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Hematologic - Blood - Diagnosisen_US
dc.subject.meshPregnancy Trimester, First - Blooden_US
dc.subject.meshPregnancy-Associated Plasma Protein-A - Analysisen_US
dc.subject.meshPrenatal Diagnosis - Methodsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshAlpha-Thalassemia - Blood - Diagnosis - Geneticsen_US
dc.titleHuman chorionic gonadotropin and plasma protein-A in alpha 0-thalassemia pregnanciesen_HK
dc.typeArticleen_HK
dc.identifier.emailOng, CYT: cytong@hkucc.hku.hken_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11135-005-2071-8en_HK
dc.identifier.pmid16946227-
dc.identifier.scopuseid_2-s2.0-33748336262en_HK
dc.identifier.hkuros124218-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748336262&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume108en_HK
dc.identifier.issue3 Ien_HK
dc.identifier.spage651en_HK
dc.identifier.epage655en_HK
dc.identifier.isiWOS:000239666400010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridLee, CP=7410149538en_HK
dc.identifier.scopusauthoridLeung, KY=8247106900en_HK
dc.identifier.scopusauthoridLau, E=7103086081en_HK
dc.identifier.scopusauthoridTang, MHY=8943401300en_HK
dc.identifier.citeulike862193-

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