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Article: Placental volume measured by three-dimensional ultrasound in the prediction of fetal α 0-thalassemia: A preliminary report

TitlePlacental volume measured by three-dimensional ultrasound in the prediction of fetal α 0-thalassemia: A preliminary report
Authors
KeywordsFetal anemia
Hb-Bart's disease
Homozygous α 0-thalassemia
Placenta
Three-dimensional ultrasound
Volume
Issue Date2006
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/
Citation
Ultrasound In Obstetrics And Gynecology, 2006, v. 28 n. 2, p. 166-172 How to Cite?
AbstractObjective: To evaluate the use of placental volume measured by three-dimensional (3D) ultrasound in predicting fetal homozygous α 0-thalassemia (Hb-Bart's disease). Methods: From June 2002 to May 2004 singleton pregnancies at risk of α 0-thalassemia and normal controls were studied prospectively at 9-12 weeks of gestation. Affected fetuses were suspected to have α 0-thalassemia by two-dimensional (2D) ultrasound and confirmed by DNA analysis. Placental volume was measured on 3D ultrasound by a multiplanar technique. Intra- and interobserver agreement of measurements was assessed. The placental volume/crown-rump length quotient of the affected fetuses was compared with that of normal fetuses. Results: The final study group comprised 105 pregnancies; 43 were at risk of α 0-thalassemia and 62 were normal controls. Eleven (10.5%) fetuses were affected by α 0-thalassemia, all from the at-risk group, and the others were normal. Intra- and interobserver agreement of volume measurement by 3D ultrasound was relatively poor; this was reflected in the wide limits of agreement, which ranged from -10.82 to 40.86 mL. The mean ± SD placental volume/crown-rump length quotient in affected pregnancies was larger than that in unaffected pregnancies (1.37 ± 0.65 vs. 1.13 ± 0.39), but this difference was not significant (P > 0.05). Conclusions: Assessment of placental volume by 3D ultrasound does not seem to be superior to 2D ultrasound in the first-trimester prediction of α 0-thalassemia. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173307
ISSN
2015 Impact Factor: 4.197
2015 SCImago Journal Rankings: 1.766
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Men_HK
dc.contributor.authorLeung, KYen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2012-10-30T06:29:12Z-
dc.date.available2012-10-30T06:29:12Z-
dc.date.issued2006en_HK
dc.identifier.citationUltrasound In Obstetrics And Gynecology, 2006, v. 28 n. 2, p. 166-172en_HK
dc.identifier.issn0960-7692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173307-
dc.description.abstractObjective: To evaluate the use of placental volume measured by three-dimensional (3D) ultrasound in predicting fetal homozygous α 0-thalassemia (Hb-Bart's disease). Methods: From June 2002 to May 2004 singleton pregnancies at risk of α 0-thalassemia and normal controls were studied prospectively at 9-12 weeks of gestation. Affected fetuses were suspected to have α 0-thalassemia by two-dimensional (2D) ultrasound and confirmed by DNA analysis. Placental volume was measured on 3D ultrasound by a multiplanar technique. Intra- and interobserver agreement of measurements was assessed. The placental volume/crown-rump length quotient of the affected fetuses was compared with that of normal fetuses. Results: The final study group comprised 105 pregnancies; 43 were at risk of α 0-thalassemia and 62 were normal controls. Eleven (10.5%) fetuses were affected by α 0-thalassemia, all from the at-risk group, and the others were normal. Intra- and interobserver agreement of volume measurement by 3D ultrasound was relatively poor; this was reflected in the wide limits of agreement, which ranged from -10.82 to 40.86 mL. The mean ± SD placental volume/crown-rump length quotient in affected pregnancies was larger than that in unaffected pregnancies (1.37 ± 0.65 vs. 1.13 ± 0.39), but this difference was not significant (P > 0.05). Conclusions: Assessment of placental volume by 3D ultrasound does not seem to be superior to 2D ultrasound in the first-trimester prediction of α 0-thalassemia. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/en_HK
dc.relation.ispartofUltrasound in Obstetrics and Gynecologyen_HK
dc.rightsUltrasound in Obstetrics & Gynecology. Copyright © John Wiley & Sons Ltd.-
dc.subjectFetal anemiaen_HK
dc.subjectHb-Bart's diseaseen_HK
dc.subjectHomozygous α 0-thalassemiaen_HK
dc.subjectPlacentaen_HK
dc.subjectThree-dimensional ultrasounden_HK
dc.subjectVolumeen_HK
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Pathology - Ultrasonographyen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshImaging, Three-Dimensionalen_US
dc.subject.meshObserver Variationen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshPlacenta - Pathology - Ultrasonographyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Firsten_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshUltrasonography, Prenatal - Methods - Standardsen_US
dc.subject.meshAlpha-Thalassemia - Pathology - Ultrasonographyen_US
dc.titlePlacental volume measured by three-dimensional ultrasound in the prediction of fetal α 0-thalassemia: A preliminary reporten_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/uog.2721en_HK
dc.identifier.pmid16652395-
dc.identifier.scopuseid_2-s2.0-33747609836en_HK
dc.identifier.hkuros150273-
dc.identifier.hkuros119980-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747609836&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue2en_HK
dc.identifier.spage166en_HK
dc.identifier.epage172en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChen, M=8340048100en_HK
dc.identifier.scopusauthoridLeung, KY=8247106900en_HK
dc.identifier.scopusauthoridLee, CP=7410149538en_HK
dc.identifier.scopusauthoridTang, MHY=35362943900en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.citeulike778817-

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