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Article: Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes

TitleMitochondrial DNA content and 4977 bp deletion in unfertilized oocytes
Authors
KeywordsAge
Deletion
Mitochondrial DNA copy number
Unfertilized oocyte
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://molehr.oxfordjournals.org/
Citation
Molecular Human Reproduction, 2006, v. 11 n. 12, p. 843-846 How to Cite?
AbstractPrevious studies analysing the incidences of mitochondrial DNA (mtDNA) deletions and mtDNA content in unfertilized oocytes in relation to donors' age have been controversial. The objective of the study was to compare these two parameters in unfertilized oocytes and relate them to the donors' age. Fifty-two women donated 155 unfertilized metaphase II (MII) oocytes. The incidence of 4977 bp deletion was 34.6%, and the mtDNA copy number was 598 350 ± 265 862. Women ≥35 years of age had a significantly higher incidence of 4977 bp deletion, lower mtDNA copy number, higher FSH level and poorer ovarian response when compared with younger women. The mtDNA copy number was negatively correlated with the donor's age. The higher incidence of mtDNA deletion and lower mtDNA copy number in older women suggested that these two parameters may reflect ovarian ageing. © 2005 Oxford University Press.
Persistent Identifierhttp://hdl.handle.net/10722/173304
ISSN
2015 Impact Factor: 3.943
2015 SCImago Journal Rankings: 1.611
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CCWen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorLau, EYLen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2012-10-30T06:29:11Z-
dc.date.available2012-10-30T06:29:11Z-
dc.date.issued2006en_HK
dc.identifier.citationMolecular Human Reproduction, 2006, v. 11 n. 12, p. 843-846en_HK
dc.identifier.issn1360-9947en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173304-
dc.description.abstractPrevious studies analysing the incidences of mitochondrial DNA (mtDNA) deletions and mtDNA content in unfertilized oocytes in relation to donors' age have been controversial. The objective of the study was to compare these two parameters in unfertilized oocytes and relate them to the donors' age. Fifty-two women donated 155 unfertilized metaphase II (MII) oocytes. The incidence of 4977 bp deletion was 34.6%, and the mtDNA copy number was 598 350 ± 265 862. Women ≥35 years of age had a significantly higher incidence of 4977 bp deletion, lower mtDNA copy number, higher FSH level and poorer ovarian response when compared with younger women. The mtDNA copy number was negatively correlated with the donor's age. The higher incidence of mtDNA deletion and lower mtDNA copy number in older women suggested that these two parameters may reflect ovarian ageing. © 2005 Oxford University Press.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://molehr.oxfordjournals.org/en_HK
dc.relation.ispartofMolecular Human Reproductionen_HK
dc.rightsMolecular Human Reproduction. Copyright © Oxford University Press.-
dc.subjectAgeen_HK
dc.subjectDeletionen_HK
dc.subjectMitochondrial DNA copy numberen_HK
dc.subjectUnfertilized oocyteen_HK
dc.subject.meshAdulten_US
dc.subject.meshDna, Mitochondrial - Genetics - Isolation & Purificationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilizationen_US
dc.subject.meshHumansen_US
dc.subject.meshInfertility, Female - Geneticsen_US
dc.subject.meshMenstrual Cycleen_US
dc.subject.meshOocytes - Physiologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSequence Deletionen_US
dc.titleMitochondrial DNA content and 4977 bp deletion in unfertilized oocytesen_HK
dc.typeArticleen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/molehr/gah243en_HK
dc.identifier.pmid16421213en_HK
dc.identifier.scopuseid_2-s2.0-33645060505en_HK
dc.identifier.hkuros113327-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645060505&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue12en_HK
dc.identifier.spage843en_HK
dc.identifier.epage846en_HK
dc.identifier.isiWOS:000235606100001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, CCW=26643394500en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridLau, EYL=7103086093en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.citeulike521428-

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