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Article: Attitude of at-risk subjects towards preimplantation genetic diagnosis of α- and β-thalassaemias in Hong Kong

TitleAttitude of at-risk subjects towards preimplantation genetic diagnosis of α- and β-thalassaemias in Hong Kong
Authors
KeywordsAsians
Attitude
Preimplantation diagnosis
Thalassaemia
Issue Date2002
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2002, v. 22 n. 6, p. 508-511 How to Cite?
AbstractObjectives: The aim of the study was to assess whether preimplantation genetic diagnosis (PGD) was an acceptable alternative to prenatal diagnosis in couples at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. Methods: An information leaflet was distributed to the women at risk. They were asked to complete a questionnaire after having an interview with a designated investigator. Results: A total of 141 valid questionnaires were analysed; 82.3%: of the women considered PGD either the same or better than conventional prenatal diagnosis. Women with an affected child or a subfertility problem were more willing to accept PGD and to undergo this procedure in their future pregnancies. Their main concern about PGD was damage to the embryo during the PGD procedure. The most important perceived advantage of PGD was avoidance of termination of an affected pregnancy. Conclusions: PGD is an acceptable alternative to conventional prenatal diagnosis in women at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. This is particularly true in women with a subfertility problem and in women who already have an affected child. Copyright © 2002 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173261
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPui, WHen_HK
dc.contributor.authorYung, HLen_HK
dc.contributor.authorChen, Men_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorPak, CHen_HK
dc.date.accessioned2012-10-30T06:28:52Z-
dc.date.available2012-10-30T06:28:52Z-
dc.date.issued2002en_HK
dc.identifier.citationPrenatal Diagnosis, 2002, v. 22 n. 6, p. 508-511en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173261-
dc.description.abstractObjectives: The aim of the study was to assess whether preimplantation genetic diagnosis (PGD) was an acceptable alternative to prenatal diagnosis in couples at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. Methods: An information leaflet was distributed to the women at risk. They were asked to complete a questionnaire after having an interview with a designated investigator. Results: A total of 141 valid questionnaires were analysed; 82.3%: of the women considered PGD either the same or better than conventional prenatal diagnosis. Women with an affected child or a subfertility problem were more willing to accept PGD and to undergo this procedure in their future pregnancies. Their main concern about PGD was damage to the embryo during the PGD procedure. The most important perceived advantage of PGD was avoidance of termination of an affected pregnancy. Conclusions: PGD is an acceptable alternative to conventional prenatal diagnosis in women at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. This is particularly true in women with a subfertility problem and in women who already have an affected child. Copyright © 2002 John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.-
dc.subjectAsiansen_HK
dc.subjectAttitudeen_HK
dc.subjectPreimplantation diagnosisen_HK
dc.subjectThalassaemiaen_HK
dc.subject.meshAdulten_US
dc.subject.meshAttitudeen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilization In Vitroen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPreimplantation Diagnosisen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshAlpha-Thalassemia - Diagnosis - Geneticsen_US
dc.subject.meshBeta-Thalassemia - Diagnosis - Geneticsen_US
dc.titleAttitude of at-risk subjects towards preimplantation genetic diagnosis of α- and β-thalassaemias in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.emailPak, CH: pcho@hku.hken_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityPak, CH=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.387en_HK
dc.identifier.pmid12116317-
dc.identifier.scopuseid_2-s2.0-0036289563en_HK
dc.identifier.hkuros68488-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036289563&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue6en_HK
dc.identifier.spage508en_HK
dc.identifier.epage511en_HK
dc.identifier.isiWOS:000176383000017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPui, WH=23109366000en_HK
dc.identifier.scopusauthoridYung, HL=7202563903en_HK
dc.identifier.scopusauthoridChen, M=26028797000en_HK
dc.identifier.scopusauthoridTang, MHY=8943401300en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridPak, CH=7402211440en_HK

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