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Article: Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies

TitleMaternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies
Authors
Issue Date2001
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2001, v. 21 n. 4, p. 270-273 How to Cite?
AbstractMaternal serum total activin-A concentration was measured in 45 pregnancies affected by trisomy 21 and 493 control unaffected pregnancies at 10-14 weeks of gestation. In the trisomy 21 pregnancies total activin-A concentration was significantly higher (1.36 MoM of the unaffected pregnancies) and in 16% of cases the level was above the 95th centile of normal. The log10 SD for the control group and the trisomy 21 group were 0.17 and 0.22, respectively. The median pregnancy associated plasma protein-A (PAPP-A) in this trisomy 21 series was 0.49 and for free β-hCG was 2.05. In the trisomy group there were significant positive associations between total activin-A and PAPP-A (0.6071) and free β-hCG (0.4255). The low median difference and the high overlap in values between trisomic and unaffected pregnancies make total activin-A of little practical use in first-trimester screening for trisomy 21. Copyright © 2001 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173252
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_US
dc.contributor.authorLiao, AWen_US
dc.contributor.authorSkentou, Hen_US
dc.contributor.authorOng, CYTen_US
dc.contributor.authorNicolaides, KHen_US
dc.date.accessioned2012-10-30T06:28:49Z-
dc.date.available2012-10-30T06:28:49Z-
dc.date.issued2001en_US
dc.identifier.citationPrenatal Diagnosis, 2001, v. 21 n. 4, p. 270-273en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/173252-
dc.description.abstractMaternal serum total activin-A concentration was measured in 45 pregnancies affected by trisomy 21 and 493 control unaffected pregnancies at 10-14 weeks of gestation. In the trisomy 21 pregnancies total activin-A concentration was significantly higher (1.36 MoM of the unaffected pregnancies) and in 16% of cases the level was above the 95th centile of normal. The log10 SD for the control group and the trisomy 21 group were 0.17 and 0.22, respectively. The median pregnancy associated plasma protein-A (PAPP-A) in this trisomy 21 series was 0.49 and for free β-hCG was 2.05. In the trisomy group there were significant positive associations between total activin-A and PAPP-A (0.6071) and free β-hCG (0.4255). The low median difference and the high overlap in values between trisomic and unaffected pregnancies make total activin-A of little practical use in first-trimester screening for trisomy 21. Copyright © 2001 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshActivinsen_US
dc.subject.meshAdulten_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blooden_US
dc.subject.meshDown Syndrome - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibins - Blooden_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy-Associated Plasma Protein-A - Analysisen_US
dc.subject.meshReference Valuesen_US
dc.titleMaternal serum levels of total activin-A in first-trimester trisomy 21 pregnanciesen_US
dc.typeArticleen_US
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_US
dc.identifier.authorityOng, CYT=rp00482en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.53en_US
dc.identifier.pmid11288115-
dc.identifier.scopuseid_2-s2.0-0035020972en_US
dc.identifier.hkuros78800-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035020972&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue4en_US
dc.identifier.spage270en_US
dc.identifier.epage273en_US
dc.identifier.isiWOS:000168324900005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSpencer, K=7202053140en_US
dc.identifier.scopusauthoridLiao, AW=7006509060en_US
dc.identifier.scopusauthoridSkentou, H=23107786000en_US
dc.identifier.scopusauthoridOng, CYT=7401968192en_US
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_US

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