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Article: Screening for trisomy 13 by fetal nuchal translucency and maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation

TitleScreening for trisomy 13 by fetal nuchal translucency and maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation
Authors
Issue Date2000
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2000, v. 20 n. 5, p. 411-416 How to Cite?
AbstractIn 42 cases of trisomy 13 at 10-14 weeks of gestation, compared with 947 controls, the median multiple of the median (MoM) of maternal serum free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein A (PAPP-A) was significantly decreased (0.506 MoM and 0.248 MoM respectively), whilst fetal nuchal translucency was increased (2.872 MoM). In 38% and 71% of cases of trisomy 13 maternal serum free β-hCG and PAPP-A was below the 5th centile of the appropriate normal range for gestation and in 62% of cases the nuchal translucency was above the 95th centile. When combined together in a multivariate algorithm with maternal age, 90% of cases of trisomy 13 could be detected at a 0.5% false positive rate or 84% at a 0.1% false positive rate. We conclude that specific trisomy 13 risks should be part of developing risk algorithms combining maternal serum biochemistry and nuchal translucency for use in first trimester screening alongside those for trisomy 21 and trisomy 18. Copyright (C) 2000 John Wiley and Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173242
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_US
dc.contributor.authorOng, Cen_US
dc.contributor.authorSkentou, Hen_US
dc.contributor.authorLiao, AWen_US
dc.contributor.authorNicolaides, KHen_US
dc.date.accessioned2012-10-30T06:28:44Z-
dc.date.available2012-10-30T06:28:44Z-
dc.date.issued2000en_US
dc.identifier.citationPrenatal Diagnosis, 2000, v. 20 n. 5, p. 411-416en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/173242-
dc.description.abstractIn 42 cases of trisomy 13 at 10-14 weeks of gestation, compared with 947 controls, the median multiple of the median (MoM) of maternal serum free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein A (PAPP-A) was significantly decreased (0.506 MoM and 0.248 MoM respectively), whilst fetal nuchal translucency was increased (2.872 MoM). In 38% and 71% of cases of trisomy 13 maternal serum free β-hCG and PAPP-A was below the 5th centile of the appropriate normal range for gestation and in 62% of cases the nuchal translucency was above the 95th centile. When combined together in a multivariate algorithm with maternal age, 90% of cases of trisomy 13 could be detected at a 0.5% false positive rate or 84% at a 0.1% false positive rate. We conclude that specific trisomy 13 risks should be part of developing risk algorithms combining maternal serum biochemistry and nuchal translucency for use in first trimester screening alongside those for trisomy 21 and trisomy 18. Copyright (C) 2000 John Wiley and Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.-
dc.subject.meshAdulten_US
dc.subject.meshAlgorithmsen_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blooden_US
dc.subject.meshChromosomes, Human, Pair 13en_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaternal Ageen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshNeck - Ultrasonographyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy, High-Risken_US
dc.subject.meshPregnancy-Associated Plasma Protein-A - Analysisen_US
dc.subject.meshPrenatal Diagnosis - Methodsen_US
dc.subject.meshTrisomyen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.titleScreening for trisomy 13 by fetal nuchal translucency and maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestationen_US
dc.typeArticleen_US
dc.identifier.emailOng, C:cytong@hkucc.hku.hken_US
dc.identifier.authorityOng, C=rp00482en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0223(200005)20:5<411::AID-PD822>3.3.CO;2-U-
dc.identifier.pmid10820411-
dc.identifier.scopuseid_2-s2.0-0034073499en_US
dc.identifier.hkuros78771-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034073499&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue5en_US
dc.identifier.spage411en_US
dc.identifier.epage416en_US
dc.identifier.isiWOS:000087284300010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSpencer, K=7202053140en_US
dc.identifier.scopusauthoridOng, C=7401968192en_US
dc.identifier.scopusauthoridSkentou, H=8058230100en_US
dc.identifier.scopusauthoridLiao, AW=7006509060en_US
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_US

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