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Article: First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein a as predictors of pregnancy complications

TitleFirst trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein a as predictors of pregnancy complications
Authors
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG
Citation
British Journal Of Obstetrics And Gynaecology, 2000, v. 107 n. 10, p. 1265-1270 How to Cite?
AbstractObjective. To examine the value of first trimester matemal serum flee β human chorionic gonadotrophin (β hCG) and pregnancy associated plasma protein A (PAPP-A) as predictors of pregnancy complications. Design. Screening study. Setting. Antenatal clinics. Population. Singleton pregnancies at 10-14 weeks of gestation. Methods Maternal serum free β hCG and PAPP-A were measured at 10-14 weeks of gestation in 5584 singleton pregnancies. In the 5297 (94.9%) pregnancies with complete follow up free β hCG and PAPP-A were compared between those with normal outcome and those resulting in miscarriage, spontaneous preterm delivery, pregnancy induced hypertension or fetal growth restriction and in those with pre-existing or gestational diabetes. Results. Maternal serum PAPP-A increased and β hCG decreased with gestation. The multiple of median maternal serum PAPP-A was significantly lower in those pregnancies resulting in miscarriage, pregnancy induced hypertension, growth restriction and in those with pre-existing or gestational diabetes mellitus, but not in those complicated by spontaneous preterm delivery. The level was ≤10th centile of the reference range in about 20% of the pregnancies that subsequently resulted in miscarriage or developed pregnancy induced hypertension or growth restriction, and in 27% of those that developed gestational diabetes. Maternal serum free β hCG was ≤10th centile of the reference range in about 15% of the pregnancies that subsequently resulted in miscarriage or developed pregnancy induced hypertension or growth restriction, and in 20% of those that developed gestational diabetes. Conclusion. Low maternal serum PAPP-A or β hCG at 10-14 weeks of gestation are associated with subsequent development of pregnancy complications.
Persistent Identifierhttp://hdl.handle.net/10722/173238
ISSN
2001 Impact Factor: 2.321
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOng, CYTen_US
dc.contributor.authorLiao, AWen_US
dc.contributor.authorSpencer, Ken_US
dc.contributor.authorMunim, Sen_US
dc.contributor.authorNicolaides, KHen_US
dc.date.accessioned2012-10-30T06:28:42Z-
dc.date.available2012-10-30T06:28:42Z-
dc.date.issued2000en_US
dc.identifier.citationBritish Journal Of Obstetrics And Gynaecology, 2000, v. 107 n. 10, p. 1265-1270en_US
dc.identifier.issn0306-5456en_US
dc.identifier.urihttp://hdl.handle.net/10722/173238-
dc.description.abstractObjective. To examine the value of first trimester matemal serum flee β human chorionic gonadotrophin (β hCG) and pregnancy associated plasma protein A (PAPP-A) as predictors of pregnancy complications. Design. Screening study. Setting. Antenatal clinics. Population. Singleton pregnancies at 10-14 weeks of gestation. Methods Maternal serum free β hCG and PAPP-A were measured at 10-14 weeks of gestation in 5584 singleton pregnancies. In the 5297 (94.9%) pregnancies with complete follow up free β hCG and PAPP-A were compared between those with normal outcome and those resulting in miscarriage, spontaneous preterm delivery, pregnancy induced hypertension or fetal growth restriction and in those with pre-existing or gestational diabetes. Results. Maternal serum PAPP-A increased and β hCG decreased with gestation. The multiple of median maternal serum PAPP-A was significantly lower in those pregnancies resulting in miscarriage, pregnancy induced hypertension, growth restriction and in those with pre-existing or gestational diabetes mellitus, but not in those complicated by spontaneous preterm delivery. The level was ≤10th centile of the reference range in about 20% of the pregnancies that subsequently resulted in miscarriage or developed pregnancy induced hypertension or growth restriction, and in 27% of those that developed gestational diabetes. Maternal serum free β hCG was ≤10th centile of the reference range in about 15% of the pregnancies that subsequently resulted in miscarriage or developed pregnancy induced hypertension or growth restriction, and in 20% of those that developed gestational diabetes. Conclusion. Low maternal serum PAPP-A or β hCG at 10-14 weeks of gestation are associated with subsequent development of pregnancy complications.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOGen_US
dc.relation.ispartofBritish Journal of Obstetrics and Gynaecologyen_US
dc.rightsBritish Journal of Obstetrics & Gynaecology. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blooden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications - Blood - Diagnosisen_US
dc.subject.meshPregnancy Outcomeen_US
dc.subject.meshPregnancy Trimester, First - Blooden_US
dc.subject.meshStaphylococcal Protein A - Blooden_US
dc.titleFirst trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein a as predictors of pregnancy complicationsen_US
dc.typeArticleen_US
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_US
dc.identifier.authorityOng, CYT=rp00482en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1471-0528.2000.tb11618.x-
dc.identifier.pmid11028579-
dc.identifier.scopuseid_2-s2.0-0033799683en_US
dc.identifier.hkuros78767-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033799683&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume107en_US
dc.identifier.issue10en_US
dc.identifier.spage1265en_US
dc.identifier.epage1270en_US
dc.identifier.isiWOS:000089558100013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridOng, CYT=7401968192en_US
dc.identifier.scopusauthoridLiao, AW=7006509060en_US
dc.identifier.scopusauthoridSpencer, K=7202053140en_US
dc.identifier.scopusauthoridMunim, S=6603159750en_US
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_US

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