Article: The role of Doppler sonography in assessment of malignant trophoblastic disease

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TitleThe role of Doppler sonography in assessment of malignant trophoblastic disease
AuthorsChan, FY1
Pun, TC2
Chau, MT2
Lam, C2
Ngan, HYS2
Wong, RLC2
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
CitationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 1996, v. 68 n. 1-2, p. 123-128 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0301-2115(96)02480-3
AbstractAn observational study on the role of Doppler sonography in the assessment of patients with malignant trophoblastic disease was performed in an Oncology Unit of a University teaching hospital. A total of 32 consecutive patients referred for chemotherapy were recruited. Twenty-three non-pregnant and Is women in the first trimester of pregnancy acted as controls. The patients were prospectively followed-up for 2 years. It was found that the uterine arterial resistance index and pulsatility index in patients who required chemotherapy were significantly lower when compared with the non-pregnant and pregnant controls; (Student t-test; P < 0.001 and P < 0.01, respectively). Stepwise regression analysis of β-hCG titres on uterine artery resistance index showed significant correlation, after controlling for uterine volume (adjusted multiple R = 0.71, P < 0.0001). There were, however, no significant independent associations between the initial uterine artery resistance index and the need for chemotherapy, number of courses of chemotherapy required, duration required for the β-hCG titre to return to normal, presence of metastatic disease, or the subsequent development of drug resistance or relapse. It was concluded that uterine arterial Doppler indices are significantly correlated with trophoblastic activity (β-hCG titres) in malignant trophoblastic disease. However, their role in the prediction of subsequent tumour behaviour need to be assessed in larger series.
ISSN0301-2115
2011 Impact Factor: 1.974
2011 SCImago Journal Rankings: 0.141
DOIhttp://dx.doi.org/10.1016/0301-2115(96)02480-3
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChan, FY
dc.contributor.authorPun, TC
dc.contributor.authorChau, MT
dc.contributor.authorLam, C
dc.contributor.authorNgan, HYS
dc.contributor.authorWong, RLC
dc.date.accessioned2012-10-30T06:28:37Z
dc.date.available2012-10-30T06:28:37Z
dc.date.issued1996
dc.description.abstractAn observational study on the role of Doppler sonography in the assessment of patients with malignant trophoblastic disease was performed in an Oncology Unit of a University teaching hospital. A total of 32 consecutive patients referred for chemotherapy were recruited. Twenty-three non-pregnant and Is women in the first trimester of pregnancy acted as controls. The patients were prospectively followed-up for 2 years. It was found that the uterine arterial resistance index and pulsatility index in patients who required chemotherapy were significantly lower when compared with the non-pregnant and pregnant controls; (Student t-test; P < 0.001 and P < 0.01, respectively). Stepwise regression analysis of β-hCG titres on uterine artery resistance index showed significant correlation, after controlling for uterine volume (adjusted multiple R = 0.71, P < 0.0001). There were, however, no significant independent associations between the initial uterine artery resistance index and the need for chemotherapy, number of courses of chemotherapy required, duration required for the β-hCG titre to return to normal, presence of metastatic disease, or the subsequent development of drug resistance or relapse. It was concluded that uterine arterial Doppler indices are significantly correlated with trophoblastic activity (β-hCG titres) in malignant trophoblastic disease. However, their role in the prediction of subsequent tumour behaviour need to be assessed in larger series.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 1996, v. 68 n. 1-2, p. 123-128 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0301-2115(96)02480-3
dc.identifier.doihttp://dx.doi.org/10.1016/0301-2115(96)02480-3
dc.identifier.epage128
dc.identifier.issn0301-2115
2011 Impact Factor: 1.974
2011 SCImago Journal Rankings: 0.141
dc.identifier.issue1-2
dc.identifier.pmid8886694
dc.identifier.scopuseid_2-s2.0-0030249546
dc.identifier.spage123
dc.identifier.urihttp://hdl.handle.net/10722/173223
dc.identifier.volume68
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
dc.publisher.placeIreland
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.relation.referencesReferences in Scopus
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blood
dc.subject.meshDrug Resistance, Neoplasm
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshNeoplasm Metastasis
dc.subject.meshPregnancy
dc.subject.meshPulsatile Flow
dc.subject.meshRegression Analysis
dc.subject.meshTrophoblastic Neoplasms - Blood Supply - Drug Therapy - Ultrasonography
dc.subject.meshUterine Neoplasms - Blood Supply - Drug Therapy - Ultrasonography
dc.subject.meshUterus - Blood Supply
dc.titleThe role of Doppler sonography in assessment of malignant trophoblastic disease
dc.typeArticle
Author Affiliations
  1. University of Queensland
  2. Queen Mary Hospital Hong Kong