File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: The role of Doppler sonography in assessment of malignant trophoblastic disease
  • Basic View
  • Metadata View
  • XML View
TitleThe role of Doppler sonography in assessment of malignant trophoblastic disease
 
AuthorsChan, FY1
Pun, TC2
Chau, MT2
Lam, C2
Ngan, HYS2
Wong, RLC2
 
Issue Date1996
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
 
CitationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 1996, v. 68 n. 1-2, p. 123-128 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0301-2115(96)02480-3
 
AbstractAn observational study on the role of Doppler sonography in the assessment of patients with malignant trophoblastic disease was performed in an Oncology Unit of a University teaching hospital. A total of 32 consecutive patients referred for chemotherapy were recruited. Twenty-three non-pregnant and Is women in the first trimester of pregnancy acted as controls. The patients were prospectively followed-up for 2 years. It was found that the uterine arterial resistance index and pulsatility index in patients who required chemotherapy were significantly lower when compared with the non-pregnant and pregnant controls; (Student t-test; P < 0.001 and P < 0.01, respectively). Stepwise regression analysis of β-hCG titres on uterine artery resistance index showed significant correlation, after controlling for uterine volume (adjusted multiple R = 0.71, P < 0.0001). There were, however, no significant independent associations between the initial uterine artery resistance index and the need for chemotherapy, number of courses of chemotherapy required, duration required for the β-hCG titre to return to normal, presence of metastatic disease, or the subsequent development of drug resistance or relapse. It was concluded that uterine arterial Doppler indices are significantly correlated with trophoblastic activity (β-hCG titres) in malignant trophoblastic disease. However, their role in the prediction of subsequent tumour behaviour need to be assessed in larger series.
 
ISSN0301-2115
2012 Impact Factor: 1.843
2012 SCImago Journal Rankings: 0.711
 
DOIhttp://dx.doi.org/10.1016/0301-2115(96)02480-3
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, FY
 
dc.contributor.authorPun, TC
 
dc.contributor.authorChau, MT
 
dc.contributor.authorLam, C
 
dc.contributor.authorNgan, HYS
 
dc.contributor.authorWong, RLC
 
dc.date.accessioned2012-10-30T06:28:37Z
 
dc.date.available2012-10-30T06:28:37Z
 
dc.date.issued1996
 
dc.description.abstractAn observational study on the role of Doppler sonography in the assessment of patients with malignant trophoblastic disease was performed in an Oncology Unit of a University teaching hospital. A total of 32 consecutive patients referred for chemotherapy were recruited. Twenty-three non-pregnant and Is women in the first trimester of pregnancy acted as controls. The patients were prospectively followed-up for 2 years. It was found that the uterine arterial resistance index and pulsatility index in patients who required chemotherapy were significantly lower when compared with the non-pregnant and pregnant controls; (Student t-test; P < 0.001 and P < 0.01, respectively). Stepwise regression analysis of β-hCG titres on uterine artery resistance index showed significant correlation, after controlling for uterine volume (adjusted multiple R = 0.71, P < 0.0001). There were, however, no significant independent associations between the initial uterine artery resistance index and the need for chemotherapy, number of courses of chemotherapy required, duration required for the β-hCG titre to return to normal, presence of metastatic disease, or the subsequent development of drug resistance or relapse. It was concluded that uterine arterial Doppler indices are significantly correlated with trophoblastic activity (β-hCG titres) in malignant trophoblastic disease. However, their role in the prediction of subsequent tumour behaviour need to be assessed in larger series.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 1996, v. 68 n. 1-2, p. 123-128 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0301-2115(96)02480-3
 
dc.identifier.doihttp://dx.doi.org/10.1016/0301-2115(96)02480-3
 
dc.identifier.epage128
 
dc.identifier.issn0301-2115
2012 Impact Factor: 1.843
2012 SCImago Journal Rankings: 0.711
 
dc.identifier.issue1-2
 
dc.identifier.pmid8886694
 
dc.identifier.scopuseid_2-s2.0-0030249546
 
dc.identifier.spage123
 
dc.identifier.urihttp://hdl.handle.net/10722/173223
 
dc.identifier.volume68
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
 
dc.publisher.placeIreland
 
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blood
 
dc.subject.meshDrug Resistance, Neoplasm
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshNeoplasm Metastasis
 
dc.subject.meshPregnancy
 
dc.subject.meshPulsatile Flow
 
dc.subject.meshRegression Analysis
 
dc.subject.meshTrophoblastic Neoplasms - Blood Supply - Drug Therapy - Ultrasonography
 
dc.subject.meshUterine Neoplasms - Blood Supply - Drug Therapy - Ultrasonography
 
dc.subject.meshUterus - Blood Supply
 
dc.titleThe role of Doppler sonography in assessment of malignant trophoblastic disease
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Chan, FY</contributor.author>
<contributor.author>Pun, TC</contributor.author>
<contributor.author>Chau, MT</contributor.author>
<contributor.author>Lam, C</contributor.author>
<contributor.author>Ngan, HYS</contributor.author>
<contributor.author>Wong, RLC</contributor.author>
<date.accessioned>2012-10-30T06:28:37Z</date.accessioned>
<date.available>2012-10-30T06:28:37Z</date.available>
<date.issued>1996</date.issued>
<identifier.citation>European Journal Of Obstetrics Gynecology And Reproductive Biology, 1996, v. 68 n. 1-2, p. 123-128</identifier.citation>
<identifier.issn>0301-2115</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/173223</identifier.uri>
<description.abstract>An observational study on the role of Doppler sonography in the assessment of patients with malignant trophoblastic disease was performed in an Oncology Unit of a University teaching hospital. A total of 32 consecutive patients referred for chemotherapy were recruited. Twenty-three non-pregnant and Is women in the first trimester of pregnancy acted as controls. The patients were prospectively followed-up for 2 years. It was found that the uterine arterial resistance index and pulsatility index in patients who required chemotherapy were significantly lower when compared with the non-pregnant and pregnant controls; (Student t-test; P &lt; 0.001 and P &lt; 0.01, respectively). Stepwise regression analysis of &#946;-hCG titres on uterine artery resistance index showed significant correlation, after controlling for uterine volume (adjusted multiple R = 0.71, P &lt; 0.0001). There were, however, no significant independent associations between the initial uterine artery resistance index and the need for chemotherapy, number of courses of chemotherapy required, duration required for the &#946;-hCG titre to return to normal, presence of metastatic disease, or the subsequent development of drug resistance or relapse. It was concluded that uterine arterial Doppler indices are significantly correlated with trophoblastic activity (&#946;-hCG titres) in malignant trophoblastic disease. However, their role in the prediction of subsequent tumour behaviour need to be assessed in larger series.</description.abstract>
<language>eng</language>
<publisher>Elsevier Ireland Ltd. The Journal&apos;s web site is located at http://www.elsevier.com/locate/ejogrb</publisher>
<relation.ispartof>European Journal of Obstetrics Gynecology and Reproductive Biology</relation.ispartof>
<subject.mesh>Chorionic Gonadotropin, Beta Subunit, Human - Blood</subject.mesh>
<subject.mesh>Drug Resistance, Neoplasm</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Neoplasm Metastasis</subject.mesh>
<subject.mesh>Pregnancy</subject.mesh>
<subject.mesh>Pulsatile Flow</subject.mesh>
<subject.mesh>Regression Analysis</subject.mesh>
<subject.mesh>Trophoblastic Neoplasms - Blood Supply - Drug Therapy - Ultrasonography</subject.mesh>
<subject.mesh>Uterine Neoplasms - Blood Supply - Drug Therapy - Ultrasonography</subject.mesh>
<subject.mesh>Uterus - Blood Supply</subject.mesh>
<title>The role of Doppler sonography in assessment of malignant trophoblastic disease</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/0301-2115(96)02480-3</identifier.doi>
<identifier.pmid>8886694</identifier.pmid>
<identifier.scopus>eid_2-s2.0-0030249546</identifier.scopus>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030249546&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>68</identifier.volume>
<identifier.issue>1-2</identifier.issue>
<identifier.spage>123</identifier.spage>
<identifier.epage>128</identifier.epage>
<publisher.place>Ireland</publisher.place>
</item>
Author Affiliations
  1. University of Queensland
  2. Queen Mary Hospital Hong Kong