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Article: The role of Doppler sonography in assessment of malignant trophoblastic disease

TitleThe role of Doppler sonography in assessment of malignant trophoblastic disease
Authors
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
Citation
European Journal Of Obstetrics Gynecology And Reproductive Biology, 1996, v. 68 n. 1-2, p. 123-128 How to Cite?
AbstractAn observational study on the role of Doppler sonography in the assessment of patients with malignant trophoblastic disease was performed in an Oncology Unit of a University teaching hospital. A total of 32 consecutive patients referred for chemotherapy were recruited. Twenty-three non-pregnant and Is women in the first trimester of pregnancy acted as controls. The patients were prospectively followed-up for 2 years. It was found that the uterine arterial resistance index and pulsatility index in patients who required chemotherapy were significantly lower when compared with the non-pregnant and pregnant controls; (Student t-test; P < 0.001 and P < 0.01, respectively). Stepwise regression analysis of β-hCG titres on uterine artery resistance index showed significant correlation, after controlling for uterine volume (adjusted multiple R = 0.71, P < 0.0001). There were, however, no significant independent associations between the initial uterine artery resistance index and the need for chemotherapy, number of courses of chemotherapy required, duration required for the β-hCG titre to return to normal, presence of metastatic disease, or the subsequent development of drug resistance or relapse. It was concluded that uterine arterial Doppler indices are significantly correlated with trophoblastic activity (β-hCG titres) in malignant trophoblastic disease. However, their role in the prediction of subsequent tumour behaviour need to be assessed in larger series.
Persistent Identifierhttp://hdl.handle.net/10722/173223
ISSN
2014 Impact Factor: 1.695
2013 SCImago Journal Rankings: 0.843
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, FYen_US
dc.contributor.authorPun, TCen_US
dc.contributor.authorChau, MTen_US
dc.contributor.authorLam, Cen_US
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorWong, RLCen_US
dc.date.accessioned2012-10-30T06:28:37Z-
dc.date.available2012-10-30T06:28:37Z-
dc.date.issued1996en_US
dc.identifier.citationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology, 1996, v. 68 n. 1-2, p. 123-128en_US
dc.identifier.issn0301-2115en_US
dc.identifier.urihttp://hdl.handle.net/10722/173223-
dc.description.abstractAn observational study on the role of Doppler sonography in the assessment of patients with malignant trophoblastic disease was performed in an Oncology Unit of a University teaching hospital. A total of 32 consecutive patients referred for chemotherapy were recruited. Twenty-three non-pregnant and Is women in the first trimester of pregnancy acted as controls. The patients were prospectively followed-up for 2 years. It was found that the uterine arterial resistance index and pulsatility index in patients who required chemotherapy were significantly lower when compared with the non-pregnant and pregnant controls; (Student t-test; P < 0.001 and P < 0.01, respectively). Stepwise regression analysis of β-hCG titres on uterine artery resistance index showed significant correlation, after controlling for uterine volume (adjusted multiple R = 0.71, P < 0.0001). There were, however, no significant independent associations between the initial uterine artery resistance index and the need for chemotherapy, number of courses of chemotherapy required, duration required for the β-hCG titre to return to normal, presence of metastatic disease, or the subsequent development of drug resistance or relapse. It was concluded that uterine arterial Doppler indices are significantly correlated with trophoblastic activity (β-hCG titres) in malignant trophoblastic disease. However, their role in the prediction of subsequent tumour behaviour need to be assessed in larger series.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrben_US
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biologyen_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blooden_US
dc.subject.meshDrug Resistance, Neoplasmen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshNeoplasm Metastasisen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPulsatile Flowen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshTrophoblastic Neoplasms - Blood Supply - Drug Therapy - Ultrasonographyen_US
dc.subject.meshUterine Neoplasms - Blood Supply - Drug Therapy - Ultrasonographyen_US
dc.subject.meshUterus - Blood Supplyen_US
dc.titleThe role of Doppler sonography in assessment of malignant trophoblastic diseaseen_US
dc.typeArticleen_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0301-2115(96)02480-3en_US
dc.identifier.pmid8886694en_US
dc.identifier.scopuseid_2-s2.0-0030249546en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030249546&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume68en_US
dc.identifier.issue1-2en_US
dc.identifier.spage123en_US
dc.identifier.epage128en_US
dc.identifier.isiWOS:A1996VJ31200020-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridChan, FY=7202586500en_US
dc.identifier.scopusauthoridPun, TC=7005509306en_US
dc.identifier.scopusauthoridChau, MT=7006073758en_US
dc.identifier.scopusauthoridLam, C=14119182300en_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.scopusauthoridWong, RLC=37062711400en_US

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