File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Use of prophylactic antibiotics in patients with carcinoma of the cervix receiving intracavitary radium insertion

TitleUse of prophylactic antibiotics in patients with carcinoma of the cervix receiving intracavitary radium insertion
Authors
Issue Date1993
PublisherI R O G Canada, Inc. The Journal's web site is located at http://www.irog.net/en-CA/index.aspx?CatID=4
Citation
European Journal Of Gynaecological Oncology, 1993, v. 14 n. 3, p. 197-201 How to Cite?
AbstractThe efficacy was studied of prophylactic antibiotics in preventing febrile morbidity in patients with carcinoma of the cervix undergoing intracavitary radium insertions. Of 93 consecutive patients who had completed external irradiation and two intracavitary radium insertions, 63 (67.74%) had fever over 37.5°C and 19 (20.43%) had fever over 38°C during radium insertion when prophylactic antibiotics were not given. When 3 gm cefoxitin was given over 24 hrs in divided doses as prophylaxis, 39 (41.93%) had fever over 37.5°C and 8 (8.60%) had fever over 38°C. The difference was found to be statistically significant for fever over 37.5°C (p < 0.001) and fever over 38°C (p < 0.05). There was no difference in the duration of fever in the two groups, but the use of antibiotic prophylaxis apparently decreased the need for subsequent therapeutic antibiotics from 13.98% to 4.30%. No difference in the febrile incidence was found when considering the size of the cervical tumour the stage of the disease, or whether it was a first or second radium insertion, or whether the patient had her menopause already. Prophylactic antibiotics were also found to be more effective in preventing febrile morbidity over 37.5°C in those receiving adjuvant chemotherapy as compared to the general study group (p < 0.025). We concluded that the use of prophylactic antibiotics has beneficial effect in decreasing febrile episodes during the period the radium was inserted, as well as in reducing subsequent need for therapeutic antibiotics, while its use in immunocompromised patients who are prone to sepsis may also be of advantage.
Persistent Identifierhttp://hdl.handle.net/10722/173192
ISSN
2015 Impact Factor: 0.58
2015 SCImago Journal Rankings: 0.307

 

DC FieldValueLanguage
dc.contributor.authorTo, WWKen_US
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorWong, LCen_US
dc.contributor.authorChoy, DTKen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:28:26Z-
dc.date.available2012-10-30T06:28:26Z-
dc.date.issued1993en_US
dc.identifier.citationEuropean Journal Of Gynaecological Oncology, 1993, v. 14 n. 3, p. 197-201en_US
dc.identifier.issn0392-2936en_US
dc.identifier.urihttp://hdl.handle.net/10722/173192-
dc.description.abstractThe efficacy was studied of prophylactic antibiotics in preventing febrile morbidity in patients with carcinoma of the cervix undergoing intracavitary radium insertions. Of 93 consecutive patients who had completed external irradiation and two intracavitary radium insertions, 63 (67.74%) had fever over 37.5°C and 19 (20.43%) had fever over 38°C during radium insertion when prophylactic antibiotics were not given. When 3 gm cefoxitin was given over 24 hrs in divided doses as prophylaxis, 39 (41.93%) had fever over 37.5°C and 8 (8.60%) had fever over 38°C. The difference was found to be statistically significant for fever over 37.5°C (p < 0.001) and fever over 38°C (p < 0.05). There was no difference in the duration of fever in the two groups, but the use of antibiotic prophylaxis apparently decreased the need for subsequent therapeutic antibiotics from 13.98% to 4.30%. No difference in the febrile incidence was found when considering the size of the cervical tumour the stage of the disease, or whether it was a first or second radium insertion, or whether the patient had her menopause already. Prophylactic antibiotics were also found to be more effective in preventing febrile morbidity over 37.5°C in those receiving adjuvant chemotherapy as compared to the general study group (p < 0.025). We concluded that the use of prophylactic antibiotics has beneficial effect in decreasing febrile episodes during the period the radium was inserted, as well as in reducing subsequent need for therapeutic antibiotics, while its use in immunocompromised patients who are prone to sepsis may also be of advantage.en_US
dc.languageengen_US
dc.publisherI R O G Canada, Inc. The Journal's web site is located at http://www.irog.net/en-CA/index.aspx?CatID=4en_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAnti-Bacterial Agents - Therapeutic Useen_US
dc.subject.meshBrachytherapy - Adverse Effectsen_US
dc.subject.meshCarcinoma - Radiotherapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFever - Prevention & Controlen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRadium - Adverse Effectsen_US
dc.subject.meshUterine Cervical Neoplasms - Radiotherapyen_US
dc.titleUse of prophylactic antibiotics in patients with carcinoma of the cervix receiving intracavitary radium insertionen_US
dc.typeArticleen_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8508874-
dc.identifier.scopuseid_2-s2.0-0027298002en_US
dc.identifier.volume14en_US
dc.identifier.issue3en_US
dc.identifier.spage197en_US
dc.identifier.epage201en_US
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridTo, WWK=7004294510en_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.scopusauthoridWong, LC=7402092003en_US
dc.identifier.scopusauthoridChoy, DTK=7102939127en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats