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Article: Lymphocyte subsets and serum immunoglobulins in patients with premature ovarian failure before and after oestrogen replacement

TitleLymphocyte subsets and serum immunoglobulins in patients with premature ovarian failure before and after oestrogen replacement
Authors
Issue Date1993
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 1993, v. 8 n. 5, p. 714-716 How to Cite?
AbstractWe have previously demonstrated that in patients with oestrogen deficiency, there was a significant reduction in the ratio of CD4 + to CD8 + lymphocytes. To test our hypothesis that oestrogen deficiency was the cause of the changes in lymphocyte subsets, we have studied the lymphocyte subsets and serum immunoglobulin levels in 35 patients with idiopathic premature ovarian failure before and after oestrogen replacement therapy. Before oestrogen replacement the lymphocyte subsets in peripheral blood were enumerated with indirect immunofluorescence techniques using monoclonal antibodies. The serum immunoglobulins (Ig) G, A and M were measured with nephelometry. After oestrogen replacement therapy, the tests were repeated around day 7-11 of the 2nd, 4th and 24th month. There was no significant change in any of these parameters by the 2nd or 4th months. After 2 years of oestrogen replacement, there was a significant decrease in the percentage of CD8 + cells, a significant increase in the CD4:CD8 ratio and a significant increase in the mean serum IgG concentration. There was no significant change in the other parameters. Our results support the hypothesis that oestrogen deficiency is the cause for the changes in the lymphocyte subsets.
Persistent Identifierhttp://hdl.handle.net/10722/173188
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorTang, GWKen_US
dc.contributor.authorLawton, JWMen_US
dc.date.accessioned2012-10-30T06:28:25Z-
dc.date.available2012-10-30T06:28:25Z-
dc.date.issued1993en_US
dc.identifier.citationHuman Reproduction, 1993, v. 8 n. 5, p. 714-716en_US
dc.identifier.issn0268-1161en_US
dc.identifier.urihttp://hdl.handle.net/10722/173188-
dc.description.abstractWe have previously demonstrated that in patients with oestrogen deficiency, there was a significant reduction in the ratio of CD4 + to CD8 + lymphocytes. To test our hypothesis that oestrogen deficiency was the cause of the changes in lymphocyte subsets, we have studied the lymphocyte subsets and serum immunoglobulin levels in 35 patients with idiopathic premature ovarian failure before and after oestrogen replacement therapy. Before oestrogen replacement the lymphocyte subsets in peripheral blood were enumerated with indirect immunofluorescence techniques using monoclonal antibodies. The serum immunoglobulins (Ig) G, A and M were measured with nephelometry. After oestrogen replacement therapy, the tests were repeated around day 7-11 of the 2nd, 4th and 24th month. There was no significant change in any of these parameters by the 2nd or 4th months. After 2 years of oestrogen replacement, there was a significant decrease in the percentage of CD8 + cells, a significant increase in the CD4:CD8 ratio and a significant increase in the mean serum IgG concentration. There was no significant change in the other parameters. Our results support the hypothesis that oestrogen deficiency is the cause for the changes in the lymphocyte subsets.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_US
dc.relation.ispartofHuman Reproductionen_US
dc.subject.meshAdulten_US
dc.subject.meshCd4-Cd8 Ratioen_US
dc.subject.meshEstradiol - Blooden_US
dc.subject.meshEstrogen Replacement Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollicle Stimulating Hormone - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin G - Blooden_US
dc.subject.meshImmunoglobulins - Blooden_US
dc.subject.meshLuteinizing Hormone - Blooden_US
dc.subject.meshLymphocyte Subsetsen_US
dc.subject.meshPrimary Ovarian Insufficiency - Drug Therapy - Immunologyen_US
dc.titleLymphocyte subsets and serum immunoglobulins in patients with premature ovarian failure before and after oestrogen replacementen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.emailTang, GWK:gwktang@hkucc.hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.identifier.authorityTang, GWK=rp00328en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8314965en_US
dc.identifier.scopuseid_2-s2.0-0027230118en_US
dc.identifier.volume8en_US
dc.identifier.issue5en_US
dc.identifier.spage714en_US
dc.identifier.epage716en_US
dc.identifier.isiWOS:A1993LD44200012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridTang, GWK=7401633864en_US
dc.identifier.scopusauthoridLawton, JWM=7102180792en_US

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